Assessing impact of drinking water exposure to GenX (hexafluoropropylene oxide dimer acid) in the Cape Fear River Basin, North Carolina

评估北卡罗来纳州开普菲尔河流域饮用水暴露于 GenX（六氟环氧丙烷二聚酸）的影响

• 批准号: 9537950
• 负责人: JANE HOPPIN
• 金额: $ 31.14万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-11-01 至 2019-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9537950
• 关键词: Acids; Address; Adult; Animals; Area; Back; Biological; Blood; Blood specimen; Chemicals; Child; Cholesterol; Cities; Clinical; Clinical Chemistry Tests; Commerce; Communication; Communities; Consumption; County; Ensure; Environment; Enzymes; Exposure to; Fright; Future; Health; Health Personnel; Human; Immunosuppression; Individual; Lipids; Liver; Maintenance; Malignant Neoplasms; Measurable; Measures; Metabolic; Methods; North Carolina; Outcome; Oxides; Paper; Participant; Physicians; Plants; Poly-fluoroalkyl substances; Process; Production; Protocols documentation; Public Health; Publishing; Questionnaires; Recording of previous events; Reporting; Research Personnel; Rivers; Sampling; Scientist; Serum; Source; Testing; Thyroid Function Tests; Thyroid Hormones; Time; Toxic effect; Ulcerative Colitis; United States Dept. of Health and Human Services; Universities; Urinalysis; Urine; Vertebrates; Water; Woman; Work; adverse pregnancy outcome; base; boys; design; dimer; drinking water; epidemiology study; exposed human population; girls; human data; liver function; meetings; member; men; recruit; thyroid disruption; water sampling; water treatment; web site

GenX (2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate) is a short-chain perfluoroalkyl substance (PFAS) generated in the production of non-stick coatings. This chemical has been detected in the Cape Fear River in North Carolina. The Cape Fear River serves as a drinking water source for ~300,000 residents in the lower Cape Fear River basin, including residents of New Hanover, Brunswick, and Pender Counties. In June 2017, community concern about this chemical in drinking water resulted in multiple public meetings of citizens trying to obtain information about their potential exposure and resulting health effects associated with consumption of drinking water. As a result of community concern, the chemical plant has reportedly stopped discharging GenX into the river. However, it is still measurable in finished drinking water and community concern still exists. This project is designed to help address community questions about GenX exposure and health effects. Little is known about how GenX is stored in the body, the toxicity of GenX, or how long the chemical will remain in the environment. To address these questions, we plan to conduct a community-based study of lower Cape Fear River area residents who are served by public utility water. We will work with community partners of the Cape Fear River Watch and the New Hanover County Department of Health to help identify a representative sample of residents, to collect biological samples, and to keep the community informed about what is known about GenX and what the study finds. We plan to recruit ~400 Wilmington area residents (100 men, 100 women, 100 boys, 100 girls) to provide blood, urine, and drinking water samples and to complete a questionnaire on their water use history. We plan to analyze blood, urine, and drinking water for GenX and related chemicals; blood and urine samples will also be used for clinical tests (lipid profile, thyroid function, liver function, and urinalysis). All results from the study will be shared with both the community as a whole and each individual participant. We will have a community advisory panel for the study to help advise about study protocols, methods of reporting back results to participants, and provide guidance on ongoing or new community concerns about GenX. This project leverages the expertise of NC State’s Center for Human Health and the Environment to respond to an emerging community concern.

GenX（2，3，3，3-四氟-2-（七氟丙氧基）-丙酸酯）是短链全氟烷基 在生产不粘涂料过程中产生的PFAS物质。检测到这种化学物质 在北卡罗来纳州的恐怖角河。Cape Fear河是一个饮用水源， 下开普菲尔河流域的约30万居民，包括新汉诺威的居民， 不伦瑞克和彭德县2017年6月，社区对饮用水中这种化学物质的关注 水导致公民多次公开会议，试图获得有关他们的信息， 与饮用水消费有关的潜在接触和由此产生的健康影响。 作为 由于社区的关注，据报道，该化工厂已停止向 河然而，它仍然是可测量的成品饮用水和社区的关注仍然 存在.该项目旨在帮助解决有关GenX暴露和健康的社区问题 方面的影响.人们对GenX如何在体内储存、GenX的毒性或储存时间知之甚少。 化学物质将留在环境中。为了解决这些问题，我们计划进行一次 对接受公用事业服务的下开普菲尔河地区居民进行的基于社区的研究 水我们将与Cape Fear River Watch和新汉诺威县的社区合作伙伴合作 卫生署协助确定有代表性的居民样本，收集生物 样本，并让社区了解有关GenX的信息以及研究 发现。我们计划招募约400名威尔明顿地区居民（100名男性，100名女性，100名男孩，100名女孩） 提供血液、尿液和饮用水样本，并完成关于其饮用水的调查问卷 利用历史。我们计划分析血液、尿液和饮用水中的GenX和相关化学物质; 血液和尿液样本也将用于临床测试（血脂谱，甲状腺功能， 肝功能和尿分析）。研究的所有结果将与社区共享， 作为一个整体和每一个单独的参与者。我们将为这项研究设立一个社区咨询小组 帮助提供有关研究方案的建议，向参与者报告结果的方法，以及 就社区对GenX的持续关注或新关注提供指导。该项目利用了 北卡罗来纳州人类健康与环境中心的专业知识，以应对新出现的 社区关注。