Maintaining and enriching the Infants Environmental Health Study (ISA)

维持和丰富婴儿环境健康研究（ISA）

• 批准号: 10443768
• 负责人: JANE HOPPIN
• 金额: $ 28.81万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10443768
• 关键词: 2,4-Dichlorophenoxyacetic Acid; 7 year old; Address; Affect; Age; Agriculture; Air; Allergic; Area; Banana; Biological; Biological Markers; Biological Monitoring; Birth; Body Weight Changes; Books; Canada; Chemical Exposure; Chemicals; Child; Child Development; Chlorpyrifos; Code; Cohort Studies; Collaborations; Communities; Community Developments; Complex; Computer software; Costa Rica; Country; County; Data; Data Analytics; Data Collection; Data Management Resources; Data Reporting; Data Security; Data Set; Development; Documentation; Ecosystem; Education; Environmental Exposure; Environmental Health; Environmental Monitoring; Epidemiology; Exhalation; Exposure to; Funding; Future; General Population; Goals; Government; Growth; Hair; Health; Health Promotion; Health Status; Height; Human; Individual; Infant; Infrastructure; International; Knowledge; Labor Unions; Longitudinal cohort; Longterm Follow-up; Maintenance; Manganese; Measures; Medical History; Modeling; Mothers; Nail plate; National Institute of Environmental Health Sciences; Nature; Nitrous Oxide; Nongovernmental Organizations; Online Systems; Outcome; Oxidative Stress; Participant; Persons; Pesticides; Policy Maker; Primary Schools; Private Sector; Production; Prospective cohort study; Protocols documentation; Questionnaires; Reporting; Research; Research Personnel; Research Project Grants; Resources; Respiratory Disease; Retrieval; Sampling; Schools; Specimen; Statistical Data Interpretation; Time; United States; Update; Validation; Water; Weight; Woman; air monitoring; base; civil society; cohort; community engagement; community planning; cypermethrin; data access; data integrity; data management; data sharing; epidemiology study; exposed human population; improved; mancozeb; meetings; member; neurobehavioral; neurobehavioral test; neurodevelopment; operation; outreach program; pesticide exposure; programs; respiratory; respiratory health; rural underserved; tool; underserved area; underserved community; urinary; vector control; web site; young woman

Understanding the potential health effects of pesticides is difficult due to the episodic nature of exposure and the lack of individual’s knowledge regarding their personal exposure. The ISA Cohort study in Costa Rica is a community-based cohort of 350 mothers and their now 5-7 year old children living in Matina County, Costa Rica, a banana growing region for the country. These individuals are exposed to a variety of different chemicals as used in agriculture, mainly banana production, vector control, and pasture, including mancozeb, chlorpyrifos, pyrimethanil, thiabendazole, cypermethrin, and 2,4-D. Exposure to these and other pesticides, as well as manganese (a component of mancozeb), has been measured through biological and environmental monitoring of the cohort for the past six years. To date, investigators have been funded to assess growth and neurobehavioral outcomes associated with pre- and post-natal exposure to these pesticides, oxidative stress, and respiratory and allergic outcomes in mothers and children. The ISA cohort provides critical information to assess the potential human health effects of pesticides as these same pesticides are used in the US as well as Costa Rica. This proposal will strengthen the ISA cohort for the long-term by: 1) creating a more consistent outreach program to inform the cohort members as well as their communities, civil society organizations, governmental organizations and private sector about study findings on a regular basis; 2) updating participant medical history including neurobehavioral and respiratory outcomes and collecting biological samples every two years; 3) establishing more complete data documentation to allow for easier collaboration and data sharing; 4) providing long term specimen storage in Costa Rica; and 5) enhancing understanding of pesticide exposure in the cohort and community through aggregation of available exposure data for cohort participants, validation of urinary biomarkers with environmental sampling, air monitoring of pesticides at primary schools situated in the study area, and statistical approaches to manage the complex exposure data. This proposal focuses on a community-engaged model to enhance long term follow-up by collecting and report data relevant to the community on a routine basis.

了解农药的潜在健康影响是困难的，因为农药的间歇性性质。 暴露和缺乏个人的知识，他们的个人暴露。 ISA队列 在哥斯达黎加进行的一项研究是一项以社区为基础的队列研究，包括350名母亲和她们现在5 - 7岁的孩子 生活在哥斯达黎加的马蒂纳县，该国的香蕉种植区。 这些人 暴露于农业中使用的各种不同化学品，主要是香蕉生产， 病媒控制和牧场，包括代森锰锌、毒死蜱、嘧霉胺、噻菌灵， 氯氰菊酯和2，4-D。 暴露于这些和其他农药，以及锰（一种成分 通过对该群体的生物和环境监测， 过去的六年。 到目前为止，研究人员已经获得资助，以评估生长和神经行为 与产前和产后暴露于这些农药、氧化应激和 母亲和儿童的呼吸和过敏后果。 ISA队列提供了关键的 评估农药对人类健康潜在影响的信息，因为这些农药是 在美国和哥斯达黎加都有使用。这项建议将加强国际海底管理局的队伍， 长期：1）创建一个更一致的外展计划，以告知队列成员以及 作为其社区、民间社会组织、政府组织和私营部门 定期了解研究结果; 2）更新参与者病史，包括 神经行为和呼吸结果，每两年收集一次生物样本; 3） 建立更完整的数据文件，以便更方便地进行协作和数据共享; 4)在哥斯达黎加提供长期样本储存;及5）加强对杀虫剂的认识 通过汇总队列的现有暴露数据确定队列和社区的暴露情况 参与者，通过环境采样验证尿液生物标志物， 农药在位于研究区的小学，和统计方法来管理 复杂的暴露数据。 该建议侧重于社区参与模式，以提高长期 定期收集和汇报与社区有关的数据，以作跟进。

项目成果

[Playful Learning: a tool for Environmental Education].

• DOI: 10.15359/rca.56-1.10
• 发表时间: 2022-01
• 期刊: Revista de ciencias ambientales = Tropical journal of environmental sciences

Pesticide risk perceptions among bystanders of aerial spraying on bananas in Costa Rica.

• DOI: 10.1016/j.envres.2020.109877
• 发表时间: 2020-10
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: Barraza D;Jansen K;Wesseling C;van Wendel de Joode B
• 通讯作者: van Wendel de Joode B

Pyrimethanil and chlorpyrifos air concentrations and pregnant women's urinary metabolites in the Infants' Environmental Health Study (ISA), Costa Rica.

• DOI: 10.1016/j.envint.2022.107328
• 发表时间: 2022-08
• 期刊: ENVIRONMENT INTERNATIONAL
• 影响因子: 11.8
• 作者: Giffin, Andrew;Hoppin, Jane A.;Cordoba, Leonel;Solano-Diaz, Karla;Ruepert, Clemens;Penaloza-Castaneda, Jorge;Lindh, Christian;Reich, Brian J.;de Joode, Berna van Wendel
• 通讯作者: de Joode, Berna van Wendel