2022-2024 US DOHaD Society Meetings

摘要 健康和疾病的发展起源（DOHaD）的基本概念，它假定早期- 生活事件或暴露决定了整个生命周期的健康结果， 美国DOHaD协会自2016年成立以来的年度全国会议就是例证。年会 汇集了具有不同背景的调查人员，否则他们可能不会相互作用，包括那些 研究领域包括发育生物学、生命过程流行病学、营养学、环境毒理学， 癌症压力和内分泌学这些人横跨美国从大学到工业的各个机构 政府机构（NIH，EPA，NIEHS）分享知识和最新进展， 环境毒物，营养素，药剂，病原体，肠道微生物群，压力，和新兴的 这些因素影响发育中的胎儿和新生儿，从而影响他们的健康和疾病。 寿命。此外，发言还深入探讨了这些因素如何可能导致有害影响， 后代，即，跨代效应。美国DOHaD协会年度会议的主要目标是 会议的目的是促进多学科的互动，并促进在这些不同主题上的合作。第二 目标是为受训人员（研究生，博士后研究员和初级教师）提供机会， 与世界知名专家互动，促进未来科学家的发展和职业机会， 外地第三个目标是继续促进多样性、包容性和性别平等代表性， 和代表性不足的少数群体作为发言人和会议领导人。特别是妇女和少数民族 在过去五次会议上，发言者和主持人分别占50%和20%以上。过去五 会议取得了巨大的成功，特别是2021年的混合（面对面和虚拟）会议 尽管新冠疫情仍在持续。这些成功为持续和永久的年度 会议.第六届、第七届和第八届年会将再次采用混合形式，并在纽约大学举行。 明尼苏达州（明尼阿波利斯，2022年），慈悲的儿童医院（堪萨斯城，2023年）和里佐中心（教堂 Hill，2024）。2022年会议的主题是“环境暴露：评估”。 方法、机制和健康成果”。与2021年的会议类似，该计划将包括 将为所有受训人员提供一个关于职业发展和赠款书写的专门日。初步 2023年和2024年的主题将涵盖孕产妇微生物群和儿童发育，外泌体， 生物标志物携带者，母体补充叶酸、胆碱和DHA对后代健康结果的影响 与表观基因组变化相关，以及与表观基因组变化相关的长期健康结果的流行病学分析， 在怀孕和哺乳期间有热应激。简而言之，美国多哈协会的优势在于其 它所代表的研究和研究这些领域的人的多样性。

ABSTRACT The fundamental concept of Developmental Origins of Health and Diseases (DOHaD), which posits that early- life events or exposures determine the health outcomes across the life span, has been well represented by the US DOHaD Society exemplified by its annual national meeting since its inception in 2016. Its annual meeting brings together investigators with diverse backgrounds who otherwise may not likely interact, including those researching in the areas of developmental biology, life course epidemiology, nutrition, environmental toxicology, cancer, stress, and endocrinology. Such individuals span institutions across the US from universities to industry to government agencies (NIH, EPA, NIEHS) to share knowledge and recent advancements on how environmental toxicants, nutrients, pharmaceutical agents, pathogens, gut microbiota, stress, and emerging factors influence developing fetuses and newborns, and thereby contribute to their health and disease across the life span. Further, presentations also delve into how such factors might lead to harmful effects in the subsequent generations, i.e., transgenerational effects. The major goal of the US DOHaD Society’s annual meeting is to foster multidisciplinary interactions and promote collaborations on these diverse topics. The second objective is to provide opportunity for trainees (graduate students, postdoctoral fellows, and junior faculty) to interact with world-renown experts, facilitating the development of future scientists and career opportunities in the field. The third objective is to continue promoting diversity, inclusivity, and equal representation of sex, gender and underrepresented minority groups as speakers and session leaders. Notably, women and minority represented >50% and >20% speakers and moderators, respectively, over the last five meetings. The past five conferences have been enormously successful, particularly the 2021 hybrid (in-person and virtual) meeting despite the ongoing COVID pandemic. Such successes provide impetus for continued and permanent annual meetings. The 6th, 7th, and 8th Annual Meetings will again be a hybrid format and held at the University of Minnesota (Minneapolis, 2022), the Mercy’s Children Hospital (Kansas City, 2023) and the Rizzo Center (Chapel Hill, 2024), respectively. The theme for the 2022 meeting will be “Environmental Exposures: Assessment Methodologies, Mechanisms, and Health Outcomes”. Analogous to the 2021 meeting, the program will include a dedicated day on career development and grant writing that will be provided in kind to all trainees. Preliminary themes for 2023 and 2024 will cover topics including maternal microbiota and child development, exosomes as carriers of biomarkers, effects of maternal supplemental folate, choline and DHA on offspring health outcomes associated with epigenomic changes, and epidemiological analyses of long-term health outcomes associated with heat stress during pregnancy and lactation. In short, the strength of the U.S. DOHaD Society lies in its diversity in terms of the research it represents and those researching these areas.