Neurocognitive mechanisms of reward - motivated memory persistence across age

项目总结/摘要 我的职业目标是领导一个研究小组，研究神经认知发展， 动机突出的记忆形成以及持久记忆如何影响行为， 物质使用障碍的风险。为了获得必要的技能，领导一个团队进行这方面的研究，我 我提出了一个项目，旨在研究奖励动机记忆的神经机制， 先前学习的奖励值对新学习的影响，以及现实世界积极情感状态的影响 从童年到成年的记忆过程。到目前为止，我的训练为我提供了一个强大的 发展认知神经科学和基本行为科学的方法论和理论基础 神经科学研究。我的职业发展计划建立在这一知识基础上， 奖励动机记忆强化训练及其与成瘾的关系， 神经影像学数据，计算建模和生态瞬时评估方法。完成 拟议的研究和培训将使我准备领导一个实验室，使用翻译的方法来研究 食欲和厌恶动机的记忆过程，以及它们如何引导未来的行为 发展，使用复杂的计算和神经成像方法。 研究项目：成瘾物质的实验通常在青春期开始， 增加了发展成成瘾的风险。中脑边缘多巴胺的正常发育变化 驱动青少年奖励敏感性和动机行为的系统，以及 海马体记忆系统可能会在青春期产生药物滥用的脆弱性。当一个富有的 大量的研究集中在奖励敏感性如何驱动反应性和完善性行为， 在青春期，很少有研究调查这种敏感性如何塑造记忆和未来的选择。目标 这项研究的目的是调查奖励动机记忆持久性的年龄相关变化， 可能导致从童年到成年的药物滥用，跨越进入和离开的过渡， 青春期我们假设青少年奖励敏感性增强了奖励动机的持久性 记忆，产生更大的易感性滥用药物。第一项研究（目标1）将确定与年龄有关的 支持奖励动机记忆的神经机制的变化。第二项研究（目标2）将 确定奖励动机的经验和相关的大脑活动如何影响随后的学习， 年龄最后，第三个研究将探讨真实世界的情感状态如何影响记忆及其与 跨年龄段的物质使用（目标3）。了解奖励的神经认知机制 在实验室和现实世界中调节记忆和指导未来的行为， 关于如何帮助预防物质使用障碍和促进健康过渡到 成年

Project Summary/Abstract My career goal is to a lead a research group that investigates the neurocognitive development of motivationally-salient memory formation and how persistent memories influence behaviors that can increase risk for substance use disorders. To acquire the necessary skills to lead a team pursuing this line of research, I propose a project that aims to examine the neural mechanisms underlying reward-motivated memory, the influence of previously learned reward value on new learning, and the impact of real-world positive affect states on memory processes from childhood to adulthood. My training to date has provided me with a strong methodological and theoretical foundation in developmental cognitive neuroscience and basic behavioral neuroscience research. My career development plan builds on this knowledge base by providing crucial, intensive training in the study of reward-motivated memory and its relation to addiction, multivariate analyses of neuroimaging data, computational modeling, and ecological momentary assessment methods. Completion of the proposed research and training will prepare me to lead a lab that uses a translational approach to study appetitive and aversive motivated memory processes and how they guide future behaviors across development, using sophisticated computational and neuroimaging approaches. Research Project: Experimentation with addictive substances often begins during adolescence, increasing the risk of progression to addiction. Normative developmental changes in mesolimbic dopamine systems, which drive adolescent reward sensitivity and motivated behaviors, alongside changes in hippocampal memory systems may yield vulnerability to substance abuse during adolescence. While a rich body of research has focused on how reward sensitivity drives reactive and consummatory behaviors during adolescence, few studies have investigated how this sensitivity shapes memory and future choices. The goal of the proposed research is to investigate age-related changes in reward-motivated memory persistence that may contribute to substance abuse from childhood to adulthood, spanning the transition into and out of adolescence. We hypothesize that adolescent reward sensitivity enhances the persistence of reward-motivated memories, yielding greater susceptibility to substance abuse. The first study (Aim 1) will identify age-related changes in the neural mechanisms supporting reward-motivated memories. The second study (Aim 2) will determine how reward-motivated experiences and related brain activity influence subsequent learning across age. Finally, the third study will investigate how real-world affective states influence memory and its relation to substance use across age (Aim 3). Understanding the neurocognitive mechanisms through which rewards modulate memory and guide future behaviors across age – both in the lab and in the real-world – may provide key insights into how to help prevent substance use disorders and to promote a healthy transition into adulthood.