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Neurocognitive mechanisms of reward - motivated memory persistence across age

奖励驱动的跨年龄记忆持久性的神经认知机制

基本信息

批准号：
10565930
负责人：
Alexandra Cohen
金额：
$ 16.07万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2027-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10565930
关键词：
Address Adolescence Adolescent Adult Affect Affective Age Behavior Behavioral Brain Child Child Abuse Childhood Cognitive Computer Models Consummatory Behavior Corpus striatum structure Data Decision Making Dependence Desire for food Development Development Plans Dopamine Ecological momentary assessment Enrollment Exhibits Foundations Functional Magnetic Resonance Imaging Future Goals Hippocampus Hour Image Intervention Knowledge Lead Learning Link Maintenance Measures Mediating Memory Methodology Methods Modeling Motivation Multivariate Analysis Neurocognitive Neuronal Plasticity Neurosciences Research Outcome Participant Patient Self-Report Pattern Physical activity Predisposition Psychological reinforcement Research Research Project Grants Rest Retrieval Rewards Risk Risk Behaviors Risk Taking Rodent Severity of illness Shapes Signal Transduction Sleep Stimulus Substance Use Disorder Substance abuse problem System Thinking Training Translating Ventral Tegmental Area Work addiction age related behavior influence career career development cognitive neuroscience experience high reward insight knowledge base memory encoding memory process memory retrieval mesolimbic system motivated behavior multimodality neural neuroimaging neuromechanism novel progression risk skills stem substance use substance use prevention translational approach

项目摘要

Project Summary/Abstract My career goal is to a lead a research group that investigates the neurocognitive development of motivationally-salient memory formation and how persistent memories influence behaviors that can increase risk for substance use disorders. To acquire the necessary skills to lead a team pursuing this line of research, I propose a project that aims to examine the neural mechanisms underlying reward-motivated memory, the influence of previously learned reward value on new learning, and the impact of real-world positive affect states on memory processes from childhood to adulthood. My training to date has provided me with a strong methodological and theoretical foundation in developmental cognitive neuroscience and basic behavioral neuroscience research. My career development plan builds on this knowledge base by providing crucial, intensive training in the study of reward-motivated memory and its relation to addiction, multivariate analyses of neuroimaging data, computational modeling, and ecological momentary assessment methods. Completion of the proposed research and training will prepare me to lead a lab that uses a translational approach to study appetitive and aversive motivated memory processes and how they guide future behaviors across development, using sophisticated computational and neuroimaging approaches. Research Project: Experimentation with addictive substances often begins during adolescence, increasing the risk of progression to addiction. Normative developmental changes in mesolimbic dopamine systems, which drive adolescent reward sensitivity and motivated behaviors, alongside changes in hippocampal memory systems may yield vulnerability to substance abuse during adolescence. While a rich body of research has focused on how reward sensitivity drives reactive and consummatory behaviors during adolescence, few studies have investigated how this sensitivity shapes memory and future choices. The goal of the proposed research is to investigate age-related changes in reward-motivated memory persistence that may contribute to substance abuse from childhood to adulthood, spanning the transition into and out of adolescence. We hypothesize that adolescent reward sensitivity enhances the persistence of reward-motivated memories, yielding greater susceptibility to substance abuse. The first study (Aim 1) will identify age-related changes in the neural mechanisms supporting reward-motivated memories. The second study (Aim 2) will determine how reward-motivated experiences and related brain activity influence subsequent learning across age. Finally, the third study will investigate how real-world affective states influence memory and its relation to substance use and mesolimbic dopamine system connectivity across age (Aim 3). Understanding the neurocognitive mechanisms through which rewards modulate memory and guide future behaviors across age – both in the lab and in the real-world – may provide key insights into how to help prevent substance use disorders and to promote a healthy transition into adulthood.

项目总结/文摘