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Rare earth nanoprobes for optical imaging and disease tracking (C3i)

用于光学成像和疾病追踪的稀土纳米探针 (C3i)

基本信息

批准号：
10663617
负责人：
PRABHAS V MOGHE
金额：
$ 15.48万
依托单位：
RUTGERS, THE STATE UNIV OF N.J.
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-15 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10663617
关键词：
AMD3100 Administrative Supplement Albumins Animal Model Animals Behavior Biological Assay Biological Markers Body Weight CXCR4 gene Cancer Model Clinical Trials Contrast Media Data Disease Disseminated Malignant Neoplasm Drug Kinetics Elements Encapsulated Erbium Ethanol Exhibits Fluorescence-Activated Cell Sorting Future Glutaral Human Image In Vitro Individual Knowledge Ligands Light Liquid substance Measurement Metabolic Methods Microfluidic Microchips Microfluidics Mus National Institute of Biomedical Imaging and Bioengineering Output Parents Performance Phase Planet Earth Polymers Process Production Property Proteins Reaction Research Serum Albumin Short Waves Signal Transduction Stream Surface Techniques Technology Time Tumor Markers biomaterial compatibility chemokine receptor commercialization contrast imaging crosslink experimental study fluorescence-guided surgery in vivo instrumentation light scattering mouse model nanoparticle nanoprobe nephelometry optical emission optical imaging overexpression parent grant programs prototype residence scale up small molecule targeted biomarker

项目摘要

PROJECT SUMMARY / ABSTRACT This project is a C3i Accell administrative supplement to our ongoing R01 project (EB018358 “Rare-earth nanoprobes for optical imaging and disease tracking”). The parent R01 project is developing short-wave infrared (SWIR) light-emitting nanoparticle contrast agents and imaging instrumentation for use in fluorescence-guided surgery. In the R01 project, mouse models of cancer are employed to evaluate the performance of these contrast agents in vivo. Through the core C3i program, we learned that successful commercialization of this technology will require us to demonstrate that contrast agent synthesis can be scaled to much larger volumes than used in our R01 murine studies, while maintaining quality and consistency. We currently synthesize nanoprobes in individual 15 ml batches which are sufficient to complete a typical longitudinal murine experiment, but inadequate for moving the technology forward into large animal models and in-human clinical trials. To enable these future studies, this C3i Accell project will develop and validate methods to synthesize nanoprobes at the 1000 ml scale. Nanoprobes will contain an erbium-doped nanoparticle core providing SWIR optical emissions, encapsulated in human serum albumin for biocompatibility, with the small molecule AMD3100 conjugated to the outer surface for targeting the CXCR4 tumor biomarker. To maintain uniformity in nanoprobe properties at this scale and to demonstrate a scalable approach for commercial production, we will develop synthesis methods using a continuous flow microfluidic platform.

项目摘要/摘要

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Surface-Modified Shortwave-Infrared-Emitting Nanophotonic Reporters for Gene-Therapy Applications.

DOI：
10.1021/acsbiomaterials.8b00378
发表时间：
2018-07-09
期刊：
ACS biomaterials science & engineering
影响因子：
5.8
作者：
Zhao Z;Kantamneni H;He S;Pelka S;Venkataraman AS;Kwon M;Libutti SK;Pierce M;Moghe PV;Ganapathy V;Tan MC
通讯作者：
Tan MC

Bioadsorption of Rare Earth Elements through Cell Surface Display of Lanthanide Binding Tags.

通过细胞表面显示镧系元素结合标签来生物吸附稀土元素。

DOI：
10.1021/acs.est.5b06129
发表时间：
2016-03-01
期刊：
Environmental science & technology
影响因子：
11.4
作者：
Park DM;Reed DW;Yung MC;Eslamimanesh A;Lencka MM;Anderko A;Fujita Y;Riman RE;Navrotsky A;Jiao Y
通讯作者：
Jiao Y

Shortwave Infrared-Emitting Theranostics for Breast Cancer Therapy Response Monitoring.

DOI：
10.3389/fmolb.2020.569415
发表时间：
2020
期刊：
Frontiers in molecular biosciences
影响因子：
5
作者：
Shah JV;Gonda A;Pemmaraju R;Subash A;Bobadilla Mendez C;Berger M;Zhao X;He S;Riman RE;Tan MC;Pierce MC;Moghe PV;Ganapathy V
通讯作者：
Ganapathy V

CXCR-4 Targeted, Short Wave Infrared (SWIR) Emitting Nanoprobes for Enhanced Deep Tissue Imaging and Micrometastatic Cancer Lesion Detection.

DOI：
10.1002/smll.201502202
发表时间：
2015-12-16
期刊：
Small (Weinheim an der Bergstrasse, Germany)
影响因子：
0
作者：
Zevon M;Ganapathy V;Kantamneni H;Mingozzi M;Kim P;Adler D;Sheng Y;Tan MC;Pierce M;Riman RE;Roth CM;Moghe PV
通讯作者：
Moghe PV

Biodegradable rare earth fluorochloride nanocrystals for phototheranostics.

用于光治疗的可生物降解稀土氟氯化物纳米晶体。