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The trigeminal nociceptive-pain pathway in pediatric mTBI: peripheral and central contributions to photophobia

儿科 mTBI 中的三叉神经伤害性疼痛通路：畏光的外周和中枢贡献

基本信息

批准号：
10656665
负责人：
Scott Holmes
金额：
$ 43.82万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10656665
关键词：
Adolescent Adopted Adult Afferent Pathways Area Behavior Brain Brain Concussion Brain imaging Case Study Central Nervous System Child Childhood Clinical Cognitive Cornea Craniocerebral Trauma Data Development Diagnosis Diffusion Magnetic Resonance Imaging Edema Event Eye Face Functional Magnetic Resonance Imaging Functional disorder Growth Headache Health Hypersensitivity Image Incidence Investigation Length Life Light Masks Measures Mediating Microscopy Monitor Nerve Nerve Fibers Neural Pathways Neurobiology Neurologic Neuronal Plasticity Nociception Optometry Organ Pain Pain Disorder Pain Threshold Paper Pathology Pathway interactions Patient Monitoring Patients Peripheral Peripheral Nervous System Persons Photophobia Population Psychology Radial Reporting Rest Risk Rodent Role Sensory Signal Transduction Source Structure Symptoms Testing Trigeminal System Trigeminal nerve structure Visual Visual Psychophysics Vulnerable Populations Work afferent nerve base brain behavior central sensitization clinical decision-making cohort density detection method diagnostic biomarker disability experience improved in vivo insight interdisciplinary approach light intensity mild traumatic brain injury multidisciplinary nerve injury nervous system disorder neuroimaging neuroinflammation pain perception pain symptom pediatric traumatic brain injury programs psychologic sensory input statistics symptomatology

项目摘要

Concussion, also referred to as mild traumatic brain injury (mTBI), is a neurological disorder that causes disability in children and predisposes them to challenges later in life, including significant physical, cognitive, and psychological disability. The trigeminal nerve extends from the central nervous system to innervate the greater portion of face and eye, and may offer insight into head trauma pathophysiology. In particular, painful sensitivity to light (photophobia), corneal nerve pathology, and atypical functional activity within the brain have all been reported in preliminary work evaluating persons with mTBI and trigeminal nerve pathology. Our overall hypothesis is that the trigeminal nerve is sensitive to mTBI and accounts for pain-related symptomatology. To test this hypothesis, in aim 1, we will define trigeminal nerve pathology in persons with mTBI using quantitative sensory testing (QST), in vivo corneal nerve microscopy (IVCM), and diffusion tensor imaging (DTI). In aim 2, we will define central nervous system changes to light-induced pathways with mTBI-related photophobia using fMRI and DTI. This study is likely to yield (1) a diagnostic marker that is sensitive to mTBI, (2) evince a neurological source of mTBI-related pain symptoms. Data generated from this investigation can be used to improve the diagnosis, treatment and monitoring of patients suffering from head trauma and provide an objective marker to base clinical decision making.

脑震荡，也被称为轻度创伤性脑损伤（mTBI），是一种神经系统疾病