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The trigeminal nociceptive-pain pathway in pediatric mTBI: peripheral and central contributions to photophobia

The trigeminal nociceptive-pain pathway in pediatric mTBI: peripheral and central contributions to photophobia
儿科 mTBI 中的三叉神经伤害性疼痛通路:畏光的外周和中枢贡献
批准号:
10656665
负责人:
Scott Holmes
金额:
$43.82万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-08-01 至 2028-06-30

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中文摘要
翻译
脑震荡,也被称为轻度创伤性脑损伤(mTBI),是一种神经系统疾病
英文摘要
Concussion, also referred to as mild traumatic brain injury (mTBI), is a neurological disorder that causes disability in children and predisposes them to challenges later in life, including significant physical, cognitive, and psychological disability. The trigeminal nerve extends from the central nervous system to innervate the greater portion of face and eye, and may offer insight into head trauma pathophysiology. In particular, painful sensitivity to light (photophobia), corneal nerve pathology, and atypical functional activity within the brain have all been reported in preliminary work evaluating persons with mTBI and trigeminal nerve pathology. Our overall hypothesis is that the trigeminal nerve is sensitive to mTBI and accounts for pain-related symptomatology. To test this hypothesis, in aim 1, we will define trigeminal nerve pathology in persons with mTBI using quantitative sensory testing (QST), in vivo corneal nerve microscopy (IVCM), and diffusion tensor imaging (DTI). In aim 2, we will define central nervous system changes to light-induced pathways with mTBI-related photophobia using fMRI and DTI. This study is likely to yield (1) a diagnostic marker that is sensitive to mTBI, (2) evince a neurological source of mTBI-related pain symptoms. Data generated from this investigation can be used to improve the diagnosis, treatment and monitoring of patients suffering from head trauma and provide an objective marker to base clinical decision making.
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Pediatric Chronic Headache and COVID-19: Use of Machine Learning and Biobehavioral Analysis to Classify Headache Mechanism and Optimize Treatment Course.
  • 批准号:
    10521562
  • 项目类别:
  • 资助金额:
    $53.74万
  • 财政年份:
    2022
  • 负责人:
    Scott Holmes
  • 依托单位:
Pediatric Chronic Headache and COVID-19: Use of Machine Learning and Biobehavioral Analysis to Classify Headache Mechanism and Optimize Treatment Course.
  • 批准号:
    10685407
  • 项目类别:
  • 资助金额:
    $53.96万
  • 财政年份:
    2022
  • 负责人:
    Scott Holmes
  • 依托单位:
海外基金