The trigeminal nociceptive-pain pathway in pediatric mTBI: peripheral and central contributions to photophobia
儿科 mTBI 中的三叉神经伤害性疼痛通路:畏光的外周和中枢贡献
基本信息
- 批准号:10656665
- 负责人:
- 金额:$ 43.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-01 至 2028-06-30
- 项目状态:未结题
- 来源:
- 关键词:AdolescentAdoptedAdultAfferent PathwaysAreaBehaviorBrainBrain ConcussionBrain imagingCase StudyCentral Nervous SystemChildChildhoodClinicalCognitiveCorneaCraniocerebral TraumaDataDevelopmentDiagnosisDiffusion Magnetic Resonance ImagingEdemaEventEyeFaceFunctional Magnetic Resonance ImagingFunctional disorderGrowthHeadacheHealthHypersensitivityImageIncidenceInvestigationLengthLifeLightMasksMeasuresMediatingMicroscopyMonitorNerveNerve FibersNeural PathwaysNeurobiologyNeurologicNeuronal PlasticityNociceptionOptometryOrganPainPain DisorderPain ThresholdPaperPathologyPathway interactionsPatient MonitoringPatientsPeripheralPeripheral Nervous SystemPersonsPhotophobiaPopulationPsychologyRadialReportingRestRiskRodentRoleSensorySignal TransductionSourceStructureSymptomsTestingTrigeminal SystemTrigeminal nerve structureVisualVisual PsychophysicsVulnerable PopulationsWorkafferent nervebasebrain behaviorcentral sensitizationclinical decision-makingcohortdensitydetection methoddiagnostic biomarkerdisabilityexperienceimprovedin vivoinsightinterdisciplinary approachlight intensitymild traumatic brain injurymultidisciplinarynerve injurynervous system disorderneuroimagingneuroinflammationpain perceptionpain symptompediatric traumatic brain injuryprogramspsychologicsensory inputstatisticssymptomatology
项目摘要
Concussion, also referred to as mild traumatic brain injury (mTBI), is a neurological disorder that causes
disability in children and predisposes them to challenges later in life, including significant physical, cognitive,
and psychological disability. The trigeminal nerve extends from the central nervous system to innervate the
greater portion of face and eye, and may offer insight into head trauma pathophysiology. In particular, painful
sensitivity to light (photophobia), corneal nerve pathology, and atypical functional activity within the brain have
all been reported in preliminary work evaluating persons with mTBI and trigeminal nerve pathology. Our overall
hypothesis is that the trigeminal nerve is sensitive to mTBI and accounts for pain-related symptomatology. To
test this hypothesis, in aim 1, we will define trigeminal nerve pathology in persons with mTBI using quantitative
sensory testing (QST), in vivo corneal nerve microscopy (IVCM), and diffusion tensor imaging (DTI). In aim 2,
we will define central nervous system changes to light-induced pathways with mTBI-related photophobia using
fMRI and DTI. This study is likely to yield (1) a diagnostic marker that is sensitive to mTBI, (2) evince a
neurological source of mTBI-related pain symptoms. Data generated from this investigation can be used to
improve the diagnosis, treatment and monitoring of patients suffering from head trauma and provide an
objective marker to base clinical decision making.
脑震荡,也称为轻度创伤性脑损伤(mTBI),是一种神经系统疾病,
残疾,使他们在以后的生活中容易受到挑战,包括重大的身体,认知,
和心理残疾。三叉神经从中枢神经系统延伸,支配
更大部分的脸和眼睛,并可能提供深入了解头部创伤病理生理学。特别是痛苦的
对光敏感(恐光症)、角膜神经病变和大脑内的非典型功能活动,
所有这些都在评估mTBI和三叉神经病理学患者的初步工作中报告。我们的整体
假设是三叉神经对mTBI敏感,并解释了疼痛相关的神经病学。到
为了验证这一假设,在目标1中,我们将使用定量方法定义mTBI患者的三叉神经病理学。
感觉测试(QST)、体内角膜神经显微镜检查(IVCM)和扩散张量成像(DTI)。在目标2中,
我们将使用以下方法定义mTBI相关恐惧症的光诱导通路的中枢神经系统变化:
fMRI和DTI。这项研究可能会产生(1)对mTBI敏感的诊断标志物,(2)表明mTBI是一种敏感的诊断标志物。
mTBI相关疼痛症状的神经源。调查产生的数据可用于
改善对头部创伤患者的诊断、治疗和监测,
客观指标作为临床决策的基础。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Scott Holmes其他文献
Scott Holmes的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Scott Holmes', 18)}}的其他基金
Pediatric Chronic Headache and COVID-19: Use of Machine Learning and Biobehavioral Analysis to Classify Headache Mechanism and Optimize Treatment Course.
小儿慢性头痛和 COVID-19:利用机器学习和生物行为分析对头痛机制进行分类并优化治疗方案。
- 批准号:
10521562 - 财政年份:2022
- 资助金额:
$ 43.82万 - 项目类别:
Pediatric Chronic Headache and COVID-19: Use of Machine Learning and Biobehavioral Analysis to Classify Headache Mechanism and Optimize Treatment Course.
小儿慢性头痛和 COVID-19:利用机器学习和生物行为分析对头痛机制进行分类并优化治疗方案。
- 批准号:
10685407 - 财政年份:2022
- 资助金额:
$ 43.82万 - 项目类别:
Hybrid enforcement-consultation Retail Food Safety Consultation Service: Using a hybrid enforcement-consultation approach and Food Protection Manager trainings to augment AMCs in local establishments.
混合执法咨询零售食品安全咨询服务:使用混合执法咨询方法和食品保护经理培训来增强当地机构的 AMC。
- 批准号:
9143121 - 财政年份:2015
- 资助金额:
$ 43.82万 - 项目类别:
Hybrid enforcement-consultation Retail Food Safety Consultation Service: Using a hybrid enforcement-consultation approach and Food Protection Manager trainings to augment AMCs in local establishments.
混合执法咨询零售食品安全咨询服务:使用混合执法咨询方法和食品保护经理培训来增强当地机构的 AMC。
- 批准号:
9110602 - 财政年份:2015
- 资助金额:
$ 43.82万 - 项目类别:
Retail Food Safety Consultation Service: Applying Behavior Change Models to Incre
零售食品安全咨询服务:应用行为改变模型增量
- 批准号:
8709831 - 财政年份:2012
- 资助金额:
$ 43.82万 - 项目类别:
Retail Food Safety Consultation Service: Applying Behavior Change Models to Incre
零售食品安全咨询服务:应用行为改变模型增量
- 批准号:
8878819 - 财政年份:2012
- 资助金额:
$ 43.82万 - 项目类别:
Retail Food Safety Consultation Service: Applying Behavior Change Models to Incre
零售食品安全咨询服务:应用行为改变模型增量
- 批准号:
8510330 - 财政年份:2012
- 资助金额:
$ 43.82万 - 项目类别:
Retail Food Safety Consultation Service: Applying Behavior Change Models to Incre
零售食品安全咨询服务:应用行为改变模型增量
- 批准号:
8544414 - 财政年份:2012
- 资助金额:
$ 43.82万 - 项目类别:
Retail Food Safety Consultation Service: Applying Behavior Change Models to Incre
零售食品安全咨询服务:应用行为改变模型增量
- 批准号:
9081232 - 财政年份:2012
- 资助金额:
$ 43.82万 - 项目类别:
相似海外基金
How novices write code: discovering best practices and how they can be adopted
新手如何编写代码:发现最佳实践以及如何采用它们
- 批准号:
2315783 - 财政年份:2023
- 资助金额:
$ 43.82万 - 项目类别:
Standard Grant
One or Several Mothers: The Adopted Child as Critical and Clinical Subject
一位或多位母亲:收养的孩子作为关键和临床对象
- 批准号:
2719534 - 财政年份:2022
- 资助金额:
$ 43.82万 - 项目类别:
Studentship
A comparative study of disabled children and their adopted maternal figures in French and English Romantic Literature
英法浪漫主义文学中残疾儿童及其收养母亲形象的比较研究
- 批准号:
2633211 - 财政年份:2020
- 资助金额:
$ 43.82万 - 项目类别:
Studentship
A material investigation of the ceramic shards excavated from the Omuro Ninsei kiln site: Production techniques adopted by Nonomura Ninsei.
对大室仁清窑遗址出土的陶瓷碎片进行材质调查:野野村仁清采用的生产技术。
- 批准号:
20K01113 - 财政年份:2020
- 资助金额:
$ 43.82万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A comparative study of disabled children and their adopted maternal figures in French and English Romantic Literature
英法浪漫主义文学中残疾儿童及其收养母亲形象的比较研究
- 批准号:
2436895 - 财政年份:2020
- 资助金额:
$ 43.82万 - 项目类别:
Studentship
A comparative study of disabled children and their adopted maternal figures in French and English Romantic Literature
英法浪漫主义文学中残疾儿童及其收养母亲形象的比较研究
- 批准号:
2633207 - 财政年份:2020
- 资助金额:
$ 43.82万 - 项目类别:
Studentship
The limits of development: State structural policy, comparing systems adopted in two European mountain regions (1945-1989)
发展的限制:国家结构政策,比较欧洲两个山区采用的制度(1945-1989)
- 批准号:
426559561 - 财政年份:2019
- 资助金额:
$ 43.82万 - 项目类别:
Research Grants
Securing a Sense of Safety for Adopted Children in Middle Childhood
确保被收养儿童的中期安全感
- 批准号:
2236701 - 财政年份:2019
- 资助金额:
$ 43.82万 - 项目类别:
Studentship
A Study on Mutual Funds Adopted for Individual Defined Contribution Pension Plans
个人设定缴存养老金计划采用共同基金的研究
- 批准号:
19K01745 - 财政年份:2019
- 资助金额:
$ 43.82万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Structural and functional analyses of a bacterial protein translocation domain that has adopted diverse pathogenic effector functions within host cells
对宿主细胞内采用多种致病效应功能的细菌蛋白易位结构域进行结构和功能分析
- 批准号:
415543446 - 财政年份:2019
- 资助金额:
$ 43.82万 - 项目类别:
Research Fellowships