Neuroimaging and Risk Factor Correlates in Aging and MCI

描述（由申请人提供）：这是一个重新修订的申请中期职业研究者奖在以患者为导向的研究（K24）。候选人Mark W.邦迪博士，ABPP/CN，在加州圣地亚哥大学精神病学副教授，建议追求的研究和指导活动的结构和功能的神经影像学的变化与老年人的风险阿尔茨海默氏病（AD）的计划。研究计划包括两个项目，候选人是PI，一个是共同研究者，所有这些项目都已获得资助并正在进行中，并提出了新的研究（见附录B）。候选人的职业目标是（1）推动他成为与AD风险相关的神经影像学变化以及临床前或早期临床AD相关的科学研究的领导者;（2）增加他在已建立和新兴的神经成像技术方面的专业知识，用于临床检测AD的转化工作，它与老年人容易患的其他疾病的准确区分，以及对治疗试验的潜在治疗反应;和（3）继续指导年轻科学家，并将这种指导扩大到上述技能领域。他坚定地致力于整合AD遗传风险人群的神经心理学和神经影像学研究。他继续职业发展的活动包括：（1）与领先的神经影像学研究科学家进行磋商;（2）新兴功能性神经影像学技术的教学和经验培训（例如，动脉自旋标记，扩散张量成像）;（3）参加部门和校园范围内的神经成像研讨会和会议;（4）扩大他作为研究导师的能力。该中期职业研究者奖的资助将为他提供机会，大幅增加用于临床研究活动的时间，从而提高他作为临床研究者的持续发展，并作为对神经心理学和神经影像学整合感兴趣的初级临床研究者的导师。由于鲜为人知的是关于潜在的功能性大脑的变化，在AD发病前的易感认知功能的高危人群，这个应用程序有望有助于重要的新方法，在表征周围的发展阿尔茨海默氏病的神经生物学底物。如果成功，我们临床前检测和监测阿尔茨海默病的能力将对早期治疗产生深远的影响。

DESCRIPTION (provided by applicant): This is a re-revised application for a Mid-Career Investigator Award in Patient-Oriented Research (K24). The candidate, Mark W. Bondi, Ph.D., ABPP/CN, Associate Professor of Psychiatry at the University of California San Diego, proposes to pursue a program of research and mentoring activity on the structural and functional neuroimaging changes related to older persons at risk for Alzheimer's disease (AD). The research plan includes two projects for which the candidate is PI, and one as Co-lnvestigator, all of which have been funded and are ongoing, and new research proposed (see Appendix B). The candidate's career goals are (1) to advance his progress in becoming a leader in the scientific study of neuroimaging changes related to those at risk for AD as well as those with preclinical or early clinical AD; (2) to increase his expertise in both established and emerging neuroimaging techniques for translational efforts in clinical detection of AD, its accurate differentiation from other disorders to which older adults are prone, and potential treatment response to therapeutic trials; and (3) to continue to mentor junior scientists and expand such mentorship to the aforementioned skill domains. He has made a strong commitment to integrating neuropsychological and neuroimaging investigations of persons at genetic risk for AD. Activities for his continued career development include (1) consultation with leading research neuroimaging scientists; (2) didactic and experiential training in emerging functional neuroimaging techniques (e.g., arterial spin labeling, diffusion tensor imaging); (3) participation in departmental and campus-wide neuroimaging seminars and meetings; and (4) expanding his capabilities as a research mentor. Funding of this Mid-Career Investigator Award will provide him with the opportunity to substantially increase the time devoted to clinical research activities, thus enhancing his continued development as a clinical investigator and as a mentor to junior clinician investigators interested in the integration of neuropsychology and neuroimaging. Since little is known concerning the underlying functional brain changes in at-risk groups on susceptible cognitive functions prior to AD onset, this application promises to contribute important new methodologies in the characterization of neurobiological substrates surrounding the development of Alzheimer's disease. If successful, our ability to preclinically detect and monitor Alzheimer's disease will have far-reaching implications for early treatment.