Neuroimaging and Risk Factor Correlates in Aging and MCI

描述(由申请人提供)：这是一份重新修订的以患者为中心的研究生涯中期研究人员奖的申请(K24)。候选人Mark W.Bondi博士，ABPP/CN，加州大学圣地亚哥分校精神病学副教授，建议开展一项与阿尔茨海默病(AD)风险较大的老年人相关的结构和功能神经成像变化的研究和指导活动计划。研究计划包括两个项目，候选人是PI，一个是联合调查员，所有这些项目都已得到资助，正在进行中，并提出了新的研究(见附录B)。候选人的职业目标是(1)推动他在与AD风险以及临床前或临床早期AD相关的神经成像变化的科学研究方面取得进展；(2)增加他在现有和新兴的神经成像技术方面的专业知识，以翻译AD的临床检测、AD与其他老年人容易发生的疾病的准确鉴别以及对治疗试验的潜在治疗反应；以及(3)继续指导初级科学家，并将这种指导扩大到上述技能领域。他坚定地致力于整合对阿尔茨海默病遗传风险人群的神经心理学和神经成像研究。他的持续职业发展活动包括(1)咨询领先的研究神经成像科学家；(2)关于新兴功能神经成像技术(例如，动脉自旋标记、扩散张量成像)的授课和经验培训；(3)参加部门和校园范围的神经成像研讨会和会议；以及(4)扩大他作为研究导师的能力。这项职业生涯中期研究人员奖的资助将使他有机会大幅增加用于临床研究活动的时间，从而加强他作为临床研究人员的持续发展，并成为对神经心理学和神经成像整合感兴趣的初级临床医生研究人员的导师。由于人们对阿尔茨海默病发病前易感认知功能高危人群的大脑潜在功能变化知之甚少，这一应用有望为表征围绕阿尔茨海默病发展的神经生物学底物贡献重要的新方法。如果成功，我们临床前检测和监测阿尔茨海默病的能力将对早期治疗产生深远影响。

DESCRIPTION (provided by applicant): This is a re-revised application for a Mid-Career Investigator Award in Patient-Oriented Research (K24). The candidate, Mark W. Bondi, Ph.D., ABPP/CN, Associate Professor of Psychiatry at the University of California San Diego, proposes to pursue a program of research and mentoring activity on the structural and functional neuroimaging changes related to older persons at risk for Alzheimer's disease (AD). The research plan includes two projects for which the candidate is PI, and one as Co-lnvestigator, all of which have been funded and are ongoing, and new research proposed (see Appendix B). The candidate's career goals are (1) to advance his progress in becoming a leader in the scientific study of neuroimaging changes related to those at risk for AD as well as those with preclinical or early clinical AD; (2) to increase his expertise in both established and emerging neuroimaging techniques for translational efforts in clinical detection of AD, its accurate differentiation from other disorders to which older adults are prone, and potential treatment response to therapeutic trials; and (3) to continue to mentor junior scientists and expand such mentorship to the aforementioned skill domains. He has made a strong commitment to integrating neuropsychological and neuroimaging investigations of persons at genetic risk for AD. Activities for his continued career development include (1) consultation with leading research neuroimaging scientists; (2) didactic and experiential training in emerging functional neuroimaging techniques (e.g., arterial spin labeling, diffusion tensor imaging); (3) participation in departmental and campus-wide neuroimaging seminars and meetings; and (4) expanding his capabilities as a research mentor. Funding of this Mid-Career Investigator Award will provide him with the opportunity to substantially increase the time devoted to clinical research activities, thus enhancing his continued development as a clinical investigator and as a mentor to junior clinician investigators interested in the integration of neuropsychology and neuroimaging. Since little is known concerning the underlying functional brain changes in at-risk groups on susceptible cognitive functions prior to AD onset, this application promises to contribute important new methodologies in the characterization of neurobiological substrates surrounding the development of Alzheimer's disease. If successful, our ability to preclinically detect and monitor Alzheimer's disease will have far-reaching implications for early treatment.