Neuroimaging and Risk Factor Correlates in Aging and MCI

神经影像学和风险因素与衰老和 MCI 相关

• 批准号: 8374369
• 负责人: Mark W Bondi
• 金额: $ 18.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8374369
• 关键词: Accounting; Activities of Daily Living; Acute; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Apolipoprotein E; Area; Behavioral; Biological Markers; Blood Vessels; Brain; Cerebral Amyloid Angiopathy; Cerebrovascular Circulation; Cerebrovascular Disorders; Cerebrum; Clinical; Clinical Investigator; Cognition; Cognitive; Coupling; Dementia; Detection; Development; Diagnosis; Differential Diagnosis; Diffusion Magnetic Resonance Imaging; Disease; Doctor of Philosophy; Early Diagnosis; Elderly; Episodic memory; Exclusion; Exhibits; Faculty; Fellowship Program; Foundations; Functional disorder; Funding; Genetic; Genetic Predisposition to Disease; Genetic Risk; Grant; High Prevalence; Image; Impaired cognition; Individual; Investigator-Initiated Research; K-Series Research Career Programs; Magnetic Resonance Imaging; Measurement; Measures; Medial; Mentors; Metabolic; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; National Research Service Awards; Neuropsychology; Outcome; Oxygen Consumption; Paper; Parietal; Pathologic; Pathology; Phase; Play; Positioning Attribute; Postdoctoral Fellow; Prevalence; Process; Publications; Publishing; Quality of life; R44 grant; Relative (related person); Reporting; Request for Proposals; Research; Research Peer Review; Research Personnel; Research Project Grants; Research Support; Resources; Rest; Risk; Risk Factors; Role; Scheme; Scientist; Shapes; Spin Labels; Structure; Symptoms; Techniques; Temporal Lobe; Time; Training; Training Programs; Training Support; United States National Institutes of Health; Veterans; Work; aged; career; career development; cerebrovascular; clinical Diagnosis; disorder risk; effective therapy; gray matter; hemodynamics; imaging modality; improved; interest; memory encoding; mild neurocognitive impairment; neuroimaging; neuropsychological; next generation; novel; patient oriented; patient oriented research; pre-clinical; programs; relating to nervous system; response; skills; tau Proteins; training project

DESCRIPTION (provided by applicant): This proposal requests continued NIA funding for the Midcareer Investigator Award in Patient-Oriented Research (K24) to Mark W. Bondi, PhD. During the first 5 years of support provided by the K24 award, Dr. Bondi has upgraded his own skill set as a research mentor by completing focused training with arterial spin labeling (ASL) and diffusion tensor imaging (DTI) MRI techniques and implementing them in his research lab with his trainees. During this period, he has obtained four patient-oriented research grants (R01, R43, and R44 grants from the NIA and an Investigator-Initiated Research Grant from the Alzheimer's Association). He has also served as primary mentor or co-mentor to 12 clinician-scientists in training. Eight of these trainees have gone on to receive either mentored or independent research support, or both, from NIH (4 NRSA; 1 SC3), the Dept of Veterans Affairs (4 VA Career Development Awards), the Dept of Defense (2 Investigator-Initiated Grants), and private foundations (3 New Investigator Research Grants from the Alzheimer's Association; 1 New Investigator Grant from AFAR). Furthermore, all of the mentees have published one or more first- authored peer-reviewed research papers reporting their work (40 unique mentee publications since 2007), and eight trainees from his lab now work in full-time academic patient-oriented faculty or research positions. The need for training and support of nascent patient-oriented researchers is both acute and profound. UCSD and the VASDHS are fortunate to have several formal training programs (including departmental T32 training grants and VA post-doctoral fellowship programs) to support the structured didactic training of clinician- scientists. Each of these programs requires the availability of skilled mentors. The K24 award permits Dr. Bondi, an established and productive clinician scientist whose integrative work in neuropsychology and neuroimaging has helped to shape our understanding of the prodromal period of Alzheimer's disease (AD), to devote substantial time to mentoring new patient-oriented researchers. It also provides him with time to enhance his own research skills in order to mentor new clinical investigators and to conduct meritorious patient-oriented research. This proposed one-time opportunity for 5 years of continued support will focus on facilitating the convergence of his research group's expertise in neuropsychology and neuroimaging studies with their growing skill and interest in the utilization of biomarkers in support of characterizing the prodromal period of dementia. With the help of several identified 'resource' experts in advanced neuroimaging and CSF biomarker techniques, Dr. Bondi proposes to enrich and deepen his research expertise in these areas with the dual aims of (1) maintaining his group's efforts at the vanguard of early detection research, and (2) simultaneously transmitting these skills to the clinician scientists he mentors in an effort to advance their own careers in patient-oriented research in early detection, diagnosis and clinical outcomes in dementia. PUBLIC HEALTH RELEVANCE: We are entering a new era of research and clinical activity that will increasingly focus on the role of biomarkers in dementia detection, diagnosis, and clinical outcome. Critical empirical appraisals of these multi-modal techniques will be needed, and the research aims of this project will seek to integrate cognitive, imaging, and other biomarker methods that best characterize the development of dementia. Through the project's training aims, the candidate will also play a major role in contributing to the career development of young investigators who will work in this interdisciplinary field as the next generation of patient-oriented researchers.

描述（由申请人提供）：该提案要求继续NIA资助以患者为导向的研究（K24）的中期职业研究者奖给Mark W。Bondi博士在K24奖提供的前5年支持期间，Bondi博士通过完成动脉自旋标记（ASL）和弥散张量成像（DTI）MRI技术的重点培训，并在他的研究实验室与学员一起实施，提升了自己作为研究导师的技能。在此期间，他获得了四项面向患者的研究赠款（NIA的R 01，R43和R44赠款以及阿尔茨海默氏症协会的研究者发起的研究补助金）。他还担任过12名临床科学家的主要导师或共同导师。这些学员中有8人继续接受NIH（4名NRSA; 1名SC 3），退伍军人事务部（4名VA职业发展奖），国防部（2名调查员发起的赠款）和私人基金会（3名来自阿尔茨海默氏症协会的新调查员研究赠款; 1名来自AFAR的新调查员赠款）的指导或独立研究支持。此外，所有的学员都发表了一篇或多篇第一作者的同行评审研究论文，报告了他们的工作（自2007年以来，有40篇独特的学员出版物），他的实验室的八名学员现在在全职学术面向患者的教师或研究职位上工作。培训和支持新生的以病人为导向的研究人员的需要是迫切和深刻的。UCSD和VASDHS有幸拥有几个正式的培训项目（包括部门T32培训赠款和VA博士后奖学金项目），以支持临床医生-科学家的结构化教学培训。 每一个项目都需要有熟练的导师。K24奖允许Bondi博士，一位成熟而富有成效的临床科学家，他在神经心理学和神经影像学方面的综合工作有助于塑造我们对阿尔茨海默病（AD）前驱期的理解，投入大量时间指导新的以患者为导向的研究人员。它还为他提供了时间来提高自己的研究技能，以指导新的临床研究人员，并进行有价值的以患者为导向的研究。这项为期5年的持续支持的一次性机会将集中于促进他的研究小组在神经心理学和神经影像学研究方面的专业知识与他们在利用生物标志物支持表征痴呆前驱期方面日益增长的技能和兴趣的融合。在先进神经影像学和CSF生物标志物技术方面的几位公认的“资源”专家的帮助下，Bondi博士建议丰富和深化他在这些领域的研究专长，其双重目标是：（1）保持他的团队在早期检测研究方面的先锋地位，（2）同时将这些技能传授给他所指导的临床科学家，以促进他们在患者方面的职业发展，在痴呆症的早期检测，诊断和临床结果的导向研究。 公共卫生关系：我们正在进入一个研究和临床活动的新时代，将越来越关注生物标志物在痴呆症检测、诊断和临床结果中的作用。将需要对这些多模式技术进行关键的经验评估，本项目的研究目标将寻求整合认知，成像和其他最能表征痴呆症发展的生物标志物方法。通过该项目的培训目标，候选人还将在促进年轻研究人员的职业发展方面发挥重要作用，这些年轻研究人员将作为下一代以患者为导向的研究人员在这一跨学科领域工作。