Network on Life Course Health Dynamics and Disparities in 21st Century America

项目总结/摘要 美国成年人健康和寿命的大多数指标都远远落后于其他富裕国家。 尽管人们越来越多地认识到这场危机，但我们对其原因的了解有限，也没有什么战略 扭转他们。这项建议是对非常成功的生命过程健康动态网络的更新， 美国国家老龄问题研究所在过去五年中资助了“21世纪世纪美国的差距”项目， 制定了进一步发展科学基础、人力资本、数据和分析基础设施的计划 回答关于美国健康和长寿危机的关键问题。我们未来的首要目标 五年是加强和重点NLCHDD产生新的证据和传播数据和分析 资源，以更好地了解美国成年人健康和寿命在整个生命过程中的趋势和差异 在地理背景下。我们将通过四个具体目标来实现这一目标。首先，我们将集中注意力和资源 针对四个有针对性的科学问题，这些问题将揭示令人不安的多层次决定因素。 美国成年人健康和寿命的趋势和日益增长的差距。这些问题（详见 建议）侧重于国家和地方背景如何单独和集体塑造的趋势和差距， 成人的健康和长寿。第二，我们将战略性地发展跨学科网络 新兴的，成熟的和代表性不足的科学家，他们将合作研究关键的科学问题， 问题.第三，我们将通过试点赠款为网络科学家提供发展和培训机会， 赠款提案指导、工作组和年度会议。第四，我们将开发和传播数据 和分析资源，以促进关键科学问题的创新研究并推进这方面的科学发展 关键区域。我们的网络是创新的，专注于趋势的多层次背景决定因素， 成人健康和寿命在整个生命过程中的差异;其开放性和不断演变的性质;其努力 将新出现的调查人员与较成熟的调查人员结合起来;在其对支助的核心关切方面， 指导，以及新兴和代表性不足的学者的发展。这种对人力资本的强调 发展体现在网络组织和运作的各个方面。网络也是独一无二的 在它的注意力集中在研究，可以告知政策和干预措施，并提供基础， 未来的研究进展。最后，我们的网络是独一无二的，因为它将促进扩展，整合， 在州和地方公开传播关于人口健康决定因素的新的和现有的数据库 contexts.更新网络汇集了一个PI团队和四个遍布美国的站点， 发展大规模人口健康研究的经验和互补的科学力量 连接到网络的目标。利用其互补优势、发展成熟度和地理优势， 多样性，NLCHDD领导层和整个网络准备在科学上取得重要进展， 未来五年美国人口健康和长寿危机。

Project Summary/Abstract Most measures of adult health and longevity in the United States lag well behind those of other wealthy countries. Despite widening recognition of this crisis, we have only a limited understanding of its causes and few strategies to reverse them. This proposal, a renewal of the highly successful Network on Life Course Health Dynamics and Disparities in 21st Century America (NLCHDD) funded for the past five years by the National Institute on Aging, lays out a plan to further develop the scientific groundwork, human capital, and data and analytic infrastructure to answer critical questions about the U.S. health and longevity crisis. Our overarching objective over the next five years is to strengthen and focus the NLCHDD to generate new evidence and disseminate data and analytic resources to better understand the trends and disparities in U.S. adult health and longevity across the life course and in geographic context. We will do so through four specific aims. First, we will direct attention and resources toward four targeted scientific questions that will shed light on the multi-layered determinants of the troubling trends and growing disparities in U.S. adult health and longevity. These questions (described in detail in the proposal) focus on how state and local contexts—separately and collectively—shape trends and disparities in adult health and longevity across the life course. Second, we will strategically grow the interdisciplinary Network of emerging, established, and underrepresented scientists who will collaborate to investigate the key scientific questions. Third, we will provide development and training opportunities for Network scientists via pilot grants, grant proposal mentoring, working groups, and annual meetings. Fourth, we will develop and disseminate data and analytic resources to foster innovative research on the key scientific questions and advance science in this critical area. Our Network is innovative in its focus on the multi-layered contextual determinants of trends and disparities in adult health and longevity across the life course; in its openness and evolving nature; in its efforts to incorporate emerging investigators with more established ones; and in its central concern for support, mentoring, and development of emerging and underrepresented scholars. This emphasis on human capital development is reflected in all aspects of the Network's organization and operation. Our Network is also unique in its attention to focusing on research that can inform policies and interventions and provide the foundation for future research advances. Finally, our Network is unique in that it will facilitate the expansion, integration, and public dissemination of new and existing databases on population health determinants at state and local contexts. The renewal Network brings together a PI team and four sites that span the U.S. with substantial experience in developing large-scale population health research and complementary scientific strengths connected to the Network’s aims. Using its complementary strengths, developmental maturity, and geographic diversity, the NLCHDD leadership and overall Network is poised to make important scientific inroads over the next five years on the U.S. population health and longevity crisis.