Network on Life Course Health Dynamics and Disparities in 21st Century America

拟议的补编包括将加入R24网络的五个创新试点项目 《21世纪美国生命历程、健康动态和差异》(NLCHDD)。所有五个人 项目是基于人口的社会科学研究，涉及NIA在#年宣布的优先事项 阿尔茨海默病和相关痴呆症(ADRD)研究领域。此外，这五个人 直接推进母基金的总体目标和具体目标。最重要的是 NLCHDD的目标是创建一个由新兴、成熟和代表性不足的人组成的网络 跨多个学科的生命历程和老龄化研究人员以生成新的证据和 传播数据和分析资源，以更好地了解令人担忧的趋势和 美国成年人的健康和寿命在整个生命过程和地理环境中存在差异。至 为了实现这一目标，NLCHDD鼓励创新和跨学科研究 通过多项活动，包括支持创新的试点项目，提供这方面的证据。 拟议的五个补充试点项目是：(1)教育、心理复原力、 而晚年的认知衰退将考察心理弹性的潜在作用 在调节和缓解受教育程度与认知之间的联系中的作用 衰退，(2)美国老年人中的邻里逆境、认知衰退和痴呆症 成年人将研究长期暴露在邻里逆境中如何影响认知能力下降 和老年人的痴呆症，以及生理失调如何调节这种联系 以及心理社会资源如何缓解这种联系，(3)阿尔茨海默氏症和 横跨城乡结合部的相关需求将考察ADRD如何在 时间和城乡连续体，以及这些模式在不同地区的不同 按性别、种族/民族和教育定义的居住和分组，(4)空气的影响- 化学毒物对老年人认知功能和认知功能损害的影响 将接触化学空气污染物的估计与HRS HCAP次样本中的受访者联系起来 并调查暴露在空气污染和社会压力源之间的协同效应 认知功能的种族/民族差异，以及(5)符合地理分布的 阿尔茨海默病和相关痴呆症向卫生政策行政部门提交 有效性：可修改的面积单位问题方法将整合来自多个 来源，以估计不同地理水平的ADRD差异，以了解如何 不同的空间单位可能会模糊ADRD中地理变化的准确表示。 这些项目将产生关于ADRD的发展和差距的重要发现。

The proposed supplement consists of five innovative pilot projects to be added to the R24 Network on Life Course Health Dynamics and Disparities in 21st Century America (NLCHDD). All five projects are population-based social science research that address NIA’s announced priorities in the area of Alzheimer’s disease and related dementias (ADRD) research. In addition, all five directly advance the overarching objective and specific aims of the parent grant. The overarching objective of the NLCHDD is to create a network of emerging, established, and underrepresented life course and aging researchers across multiple disciplines to generate new evidence and disseminate data and analytic resources to better understand the worrisome trends and disparities in U.S. adult health and longevity across the life course and in geographic context. To achieve this objective, the NLCHDD stimulates innovative and interdisciplinary research to generate this evidence through multiple activities, including supporting innovative pilot projects. The five proposed supplemental pilot projects are: (1) Education, Psychological Resilience, and Cognitive Decline in Later Life will examine the potential role that psychological resilience plays in mediating and mitigating the association between educational attainment and cognitive decline, (2) Neighborhood Adversity and Cognitive Decline and Dementia Among US Older Adults will examine how long-term exposure to neighborhood adversity impacts cognitive decline and dementia in older ages, and how physiological dysregulation may mediate the association and how psychosocial resources could mitigate the association, (3) Alzheimer’s Disease and Related Dementias across the Rural-Urban Continuum will examine how ADRD develops over time and across the urban-rural continuum, and how these patterns differ across region of residence and subgroups defined by gender, race/ethnicity, and education, (4) Effects of Air- based Chemical Toxicants on Cognitive Function and Impairment Among Older Adults will link estimates of exposure to chemical air pollutants to respondents in the HRS HCAP subsample and investigate the synergistic effects of exposure to air pollution and social stressors on race/ethnic disparities in cognitive functioning, and (5) Fitting the Geographic Distribution of Alzheimer’s Disease and Related Dementias to Administrative Divisions for Health Policy Effectiveness: A Modifiable Areal Unit Problem Approach will integrate data from multiple sources to estimate variation in ADRD across various levels of geography to understand how different spatial units may obscure accurate representation of geographic variation in ADRD. These projects will produce important findings about the development of and disparities in ADRD.