Network on Life Course Health Dynamics and Disparities in 21st Century America

21 世纪美国生命历程健康动态和差异网络

• 批准号: 10288522
• 负责人: JENNIFER A AILSHIRE
• 金额: $ 40.92万
• 依托单位: SYRACUSE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10288522
• 关键词: Address; Administrative Supplement; Adult; Age; Aging; Air; Air Pollutants; Air Pollution; Alzheimer' s Disease; Alzheimer' s disease related dementia; Americas; Area; Award; Behavioral; Chemical Exposure; Chemicals; Cognition; Data Analytics; Dementia; Development; Discipline; Education; Effectiveness; Elderly; Electronic Medical Records and Genomics Network; Ethnic Origin; Exposure to; Foundations; Funding; Gender; Geographic Distribution; Geography; Goals; Grant; Health; Health Policy; Health trends; Impaired cognition; Interdisciplinary Study; Life Cycle Stages; Link; Longevity; Measures; Mediating; Mediator of activation protein; Metabolic; Monoclonal Antibody R24; Neighborhoods; Pattern; Physiological; Pilot Projects; Play; Race; Request for Applications; Research; Research Personnel; Resources; Respondent; Risk; Role; Rural; Sampling; Scientist; Subgroup; Time; Time trend; United States National Institutes of Health; Variant; base; career; cognitive function; ethnic disparity; geographic difference; health disparity; innovation; member; multiple data sources; parent grant; population based; programs; psychologic; psychosocial; residence; resilience; social; social science research; social stressor; success; toxicant; trend

The proposed supplement consists of five innovative pilot projects to be added to the R24 Network on Life Course Health Dynamics and Disparities in 21st Century America (NLCHDD). All five projects are population-based social science research that address NIA’s announced priorities in the area of Alzheimer’s disease and related dementias (ADRD) research. In addition, all five directly advance the overarching objective and specific aims of the parent grant. The overarching objective of the NLCHDD is to create a network of emerging, established, and underrepresented life course and aging researchers across multiple disciplines to generate new evidence and disseminate data and analytic resources to better understand the worrisome trends and disparities in U.S. adult health and longevity across the life course and in geographic context. To achieve this objective, the NLCHDD stimulates innovative and interdisciplinary research to generate this evidence through multiple activities, including supporting innovative pilot projects. The five proposed supplemental pilot projects are: (1) Education, Psychological Resilience, and Cognitive Decline in Later Life will examine the potential role that psychological resilience plays in mediating and mitigating the association between educational attainment and cognitive decline, (2) Neighborhood Adversity and Cognitive Decline and Dementia Among US Older Adults will examine how long-term exposure to neighborhood adversity impacts cognitive decline and dementia in older ages, and how physiological dysregulation may mediate the association and how psychosocial resources could mitigate the association, (3) Alzheimer’s Disease and Related Dementias across the Rural-Urban Continuum will examine how ADRD develops over time and across the urban-rural continuum, and how these patterns differ across region of residence and subgroups defined by gender, race/ethnicity, and education, (4) Effects of Air- based Chemical Toxicants on Cognitive Function and Impairment Among Older Adults will link estimates of exposure to chemical air pollutants to respondents in the HRS HCAP subsample and investigate the synergistic effects of exposure to air pollution and social stressors on race/ethnic disparities in cognitive functioning, and (5) Fitting the Geographic Distribution of Alzheimer’s Disease and Related Dementias to Administrative Divisions for Health Policy Effectiveness: A Modifiable Areal Unit Problem Approach will integrate data from multiple sources to estimate variation in ADRD across various levels of geography to understand how different spatial units may obscure accurate representation of geographic variation in ADRD. These projects will produce important findings about the development of and disparities in ADRD.

拟议的补充包括将添加到 R24 网络的五个创新试点项目 关于 21 世纪美国生命历程健康动态和差异 (NLCHDD)。全部五个 项目是基于人口的社会科学研究，旨在解决 NIA 宣布的优先事项 阿尔茨海默病和相关痴呆症 (ADRD) 研究领域。此外，所有五 直接推进母基金的总体目标和具体目标。首要的 NLCHDD 的目标是创建一个由新兴、成熟和代表性不足的网络 跨学科的生命历程和衰老研究人员产生新的证据和 传播数据和分析资源，以更好地了解令人担忧的趋势和 美国成年人在生命历程中和地理环境中健康和寿命的差异。到 为了实现这一目标，NLCHDD 鼓励创新和跨学科研究 通过多项活动产生这些证据，包括支持创新试点项目。 拟议的五个补充试点项目是：(1) 教育、心理弹性、 和晚年认知衰退将研究心理弹性的潜在作用 在调解和减轻教育程度与认知之间的联系中发挥作用 下降，(2) 美国老年人的邻里逆境以及认知能力下降和痴呆症 成年人将研究长期暴露在邻里逆境中如何影响认知能力下降 和老年痴呆症，以及生理失调如何介导这种关联 以及心理社会资源如何减轻这种关联，(3) 阿尔茨海默病和 跨城乡连续体的相关痴呆症将研究 ADRD 如何发展 时间和城乡连续体，以及这些模式在不同地区有何不同 按性别、种族/族裔和教育程度定义的居住地和亚组，(4) 空气的影响 基于化学毒物对老年人认知功能和损害的影响 将化学空气污染物暴露估计值与 HRS HCAP 子样本中的受访者联系起来 并研究暴露于空气污染和社会压力因素对 认知功能方面的种族/民族差异，以及 (5) 拟合地理分布 阿尔茨海默病和相关痴呆症卫生政策行政部门 有效性：可修改的面积单位问题方法将整合来自多个 估计 ADRD 在不同地理层面的变化的来源，以了解如何 不同的空间单位可能会掩盖 ADRD 地理变化的准确表示。 这些项目将产生关于 ADRD 的发展和差异的重要发现。