The Washington University Center for Diabetes Translation Research

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PROJECT SUMMARY/ABSTRACT – Overview This is an application for the continuation of the Washington University Center for Diabetes Translation Research (WU-CDTR). The Center is guided by our strategic vision in which a health equity lens is the foundation for transformative diabetes research translated into action and impact. This equity-driven vision informs our Center mission to be the nexus for transdisciplinary team science in advancing the conduct of the next generation of diabetes translation research. Our goal is to advance a rigorous, scientific evidence base to inform the dissemination, implementation, and sustainability of efficacious interventions for populations at risk for diabetes disparities. The WU-CDTR is the intellectual home to an outstanding network of investigators who conduct research on the root causes of diabetes inequities, informed by social determinants of health and organized around five thematic areas: biobehavioral discovery; living and working conditions; health care context; health information and technology environment; and community, policy and systems research. The research base consists of 87 investigators (66 Full Members and 21 Associate Members) from within Washington University, and 21 different universities with members affiliated through our Regional and National Resource Cores (Department of Health Management and Informatics at the University of Missouri in Columbia; and the Council on Black Health at Drexel University in Pennsylvania, respectively). Our research base is defined by established (69%) and new diabetes investigators (31%), as well as those from underrepresented minority populations (38%); members work in collaboration with a network of multi-sectoral partners (N=73) including healthcare and non-health care organizations. From 2016 to present, WU-CDTR investigators were awarded $243.2 million in total direct costs and $66.8 million in annual direct costs. This includes 86 current and ongoing Center supported grants generating $173.3 million in total direct costs and $40.7 million in annual direct costs; 65% of WU-CDTR Full Members have NIH funding, and 80% of total grant support is from federal sources. The WU-CDTR is organized around five novel Translational Research Cores, led by national experts in their respective fields. They include cores on: Dissemination and Implementation in Diabetes Research; Policy and Systems Science Analysis; Health Communication and Social Needs; Health Informatics in Diabetes Research (Regional Resource); and Solutions to Diabetes in Black Americans (National Resource). We also sponsor a very successful Pilot and Feasibility Program focused on early stage and under- represented minority investigators and a vibrant Enrichment Program, which enhances education and awareness of diabetes translation research. The WU-CDTR enhances efficiency, productivity, and rapid research translation across a national network of investigators while fostering collaborations to achieve diabetes health equity.