T32 Training Program in Mechanisms and Innovation in Vascular Disease

T32血管疾病机制与创新培训项目

• 批准号: 10669582
• 负责人: Nicholas James Leeper
• 金额: $ 47.93万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669582
• 关键词: Training Programs; Vascular Diseases; innovation

Project Summary This T32 translational vascular research training program builds on the capabilities of the Stanford Cardiovascular Institute, which provides valuable unique and innovative professional development opportunities to a diverse group of promising early career investigators in vascular disease management. It supports NHLBI’s mission to develop novel integrative strategies to prevent, diagnose, and treat cardiovascular diseases, while at the same time fulfilling its educational goal to train tomorrow’s leaders in basic, translational, and applied vascular research. This T32 is Stanford's only University-wide effort to develop the next generation of translational vascular investigators. The program goals include rigorous training in the scientific method, critical analysis, logical reasoning and independent thinking in a highly collaborative, multidisciplinary setting. Trainees develop a focused area of vascular research expertise and are exposed to a wide range of complementary research techniques. Mentors model collegial and productive collaboration provide guidance in oral and written communication and instill respect for the responsible conduct of research. Our past trainees have gone on to become independent researchers in premier academic institutions and in industry and are emerging leaders in the field of vascular research. The program proposes to continue training 6 postdoctoral fellows in multidisciplinary vascular research. Fellows are appointed to this T32 annually, with a strong encouragement to seek their own funding for additional years as part of the skills imparted by the program. 31 trainees so far have benefited from this program, including 18 women and 4 underrepresented minorities. Six are currently in training. Evaluations suggest a high degree of satisfaction with the program. The Program is directed by Philip Tsao, PhD (Contact PI), Professor of Medicine, Stanford University School of Medicine; Associate Chief of Staff -Precision Medicine, VA Palo Alto Health Care System, and Nicholas Leeper, MD, Professor of Surgery and Medicine; Chief, Vascular Medicine, Stanford. Administrative and program management support is provided by a dedicated team of educators in the Stanford Cardiovascular Institute. An Internal Advisory Board consisting of senior Stanford faculty from a broad range of disciplines and an External Advisory Board consisting of leading experts in vascular medicine and research in the US play a vital role in monitoring the progress of this training program, providing ongoing support and advice as needed. Our overarching goal is to train the next generation of investigators in vascular research, and to facilitate their transition into productive and successful academic and industry leaders.

项目摘要 这个T32转化血管研究培训计划建立在斯坦福大学的能力之上 心血管研究所，提供宝贵的独特和创新的专业发展机会 一群在血管疾病管理方面有前途的早期职业研究者。支持NHLBI 使命是开发新的综合战略，以预防，诊断和治疗心血管疾病，而在 同时实现其教育目标，培养明天的领导者在基础，翻译，和应用血管 research.这个T32是斯坦福大学唯一一个在全校范围内致力于开发下一代翻译 血管研究者该计划的目标包括科学方法，批判性分析， 逻辑推理和独立思考，在高度协作，多学科的设置。受训者发展 血管研究专业知识的重点领域，并接触到广泛的补充研究 技术.导师示范学院和生产性合作提供指导，在口头和书面 沟通和灌输尊重负责任的研究行为。我们过去的学员 成为一流学术机构和行业的独立研究人员，并在以下领域成为新兴领导者： 血管研究领域。 该项目拟继续培养6名多学科血管研究博士后。家伙 每年都被任命为T32，并强烈鼓励他们在未来几年内寻求自己的资金 作为课程传授的技能的一部分。到目前为止，已有31名学员受益于该方案，其中包括18名 妇女和4个代表性不足的少数民族。目前有6人正在接受培训。评估表明， 对节目的满意度。该计划是由菲利普曹，博士（联系PI），医学教授， 斯坦福大学医学院;助理参谋长-精准医学，弗吉尼亚州帕洛阿尔托医疗保健 系统，和尼古拉斯Leeper，医学博士，外科和医学教授;主任，血管医学，斯坦福大学。 行政和项目管理支持由斯坦福大学的一个专门的教育工作者团队提供 心血管研究所。一个内部顾问委员会，由来自广泛领域的高级斯坦福大学教师组成， 学科和外部咨询委员会，由血管医学和研究领域的领先专家组成， 美国在监督这一训练计划的进展、提供持续的支持和建议方面发挥着至关重要的作用 根据需要我们的首要目标是培训血管研究领域的下一代研究人员，并且 促进他们转变为富有成效和成功的学术和行业领导者。

项目成果

Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells.

• DOI: 10.1242/bio.20146767
• 发表时间: 2014-02-15
• 期刊: Biology open
• 影响因子: 2.4
• 作者: Li Y;Hao H;Tzatzalos E;Lin RK;Doh S;Liu LF;Lyu YL;Cai L
• 通讯作者: Cai L

A novel pacing maneuver to verify the postpacing interval minus the tachycardia cycle length while adjusting for decremental conduction: Using "dual-chamber entrainment" for improved supraventricular tachycardia discrimination.

一种新颖的起搏操作，用于验证起搏后间隔减去心动过速周期长度，同时调整递减传导：使用“双腔夹带”改善室上性心动过速辨别。

• DOI: 10.1016/j.hrthm.2018.11.021
• 发表时间: 2019
• 期刊: Heart rhythm
• 影响因子: 5.5
• 作者: Kaiser,DanielW;Nasir,JavedM;Liem,LBing;Brodt,Chad;Motonaga,KaraS;Ceresnak,ScottR;Turakhia,MintuP;Dubin,AnneM
• 通讯作者: Dubin,AnneM

Mechanisms of vascular endothelial growth factor-induced pathfinding by endothelial sprouts in biomaterials.

血管内皮生长因子诱导生物材料中内皮芽寻路的机制。

• DOI: 10.1089/ten.tea.2011.0323
• 发表时间: 2012
• 期刊: Tissue engineering. Part A
• 作者: Shamloo,Amir;Xu,Hui;Heilshorn,Sarah
• 通讯作者: Heilshorn,Sarah

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.

• DOI: 10.1016/j.cmet.2018.01.005
• 发表时间: 2018-03-06
• 期刊: Cell metabolism
• 影响因子: 29
• 作者: Mardinoglu A;Wu H;Bjornson E;Zhang C;Hakkarainen A;Räsänen SM;Lee S;Mancina RM;Bergentall M;Pietiläinen KH;Söderlund S;Matikainen N;Ståhlman M;Bergh PO;Adiels M;Piening BD;Granér M;Lundbom N;Williams KJ;Romeo S;Nielsen J;Snyder M;Uhlén M;Bergström G;Perkins R;Marschall HU;Bäckhed F;Taskinen MR;Borén J
• 通讯作者: Borén J

Role of extracellular matrix signaling cues in modulating cell fate commitment for cardiovascular tissue engineering.

• DOI: 10.1002/adhm.201300620
• 发表时间: 2014-05
• 期刊: Advanced healthcare materials
• 影响因子: 10
• 作者: Nakayama KH;Hou L;Huang NF
• 通讯作者: Huang NF