Pathways to Mentorship and Research: Training the Next Generation Physician-Scientists

指导和研究途径：培训下一代医生科学家

• 批准号: 10672162
• 负责人: Jatin M Vyas
• 金额: $ 35.1万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-12 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10672162
• 关键词: Address; Antimicrobial Resistance; Area; Automobile Driving; Basic Science; Bioinformatics; Biomedical Research; Boston; Career Choice; Clinic; Clinical; Clinical Medicine; Clinical Research; Clinical Skills; Communicable Diseases; Communication; Communities; Coupled; Dedications; Development; Development Plans; Educational process of instructing; Epidemiology; Faculty; Failure; Fostering; Frustration; Funding; General Hospitals; HIV/AIDS; Health; Health Care Research; Hospitalists; Human; Immunology; Immunosuppressive Agents; Individual; Infection; Inpatients; Institution; Intellectual Interest; Internist; Investigation; Knowledge; Laboratories; Leadership; Learning; Massachusetts; Medical; Medical Education; Medical Students; Medicine; Mentors; Mentorship; Methodology; Modeling; Morbidity - disease rate; National Institute of Allergy and Infectious Disease; Operative Surgical Procedures; Outcome; Participant; Pathway interactions; Patient Care; Patients; Physicians; Play; Prevalence; Productivity; Public Health; Readiness; Research; Research Personnel; Research Project Grants; Residencies; Role; Science; Scientist; Source; Structure; Surgeon; Time; Training; Translating; Transplantation; Transplantation Immunology; Work; apprenticeship; career; clinical investigation; cost effectiveness; design; experience; improved; innovation; interest; medical schools; mortality; next generation; pathogen; preservation; programs; research and development; role model; skill acquisition; skills; statistics; success; symposium; time use; translational study

PROJECT SUMMARY Physician-scientists play a unique role in bridging the gap between basic science and clinicians through the identification of important clinical questions and translating results to improve patient care. Unfortunately, the physician-scientist workforce continues to diminish and contributes to negative, long-lasting consequences in biomedical research. Many residency programs focus heavily on acquiring medical knowledge as opposed to fostering intellectual curiosity and an introduction into the biomedical research field. In this proposal, we aim to enhance attractiveness and preparedness for a career as a physician-scientist during residency training. Furthering the diminishing interest in a career as a physician-scientist is the ability to identify an encouraging and successful mentor. There is a critical need for a renewed emphasis on established physician- scientists as role models to trainees. Infectious Disease and Immunology are fundamental areas of science that greatly benefits from a robust physician-scientist workforce. Massachusetts General Hospital/Harvard Medical School, particularly in the Departments of Medicine and Surgery, has a long track record of training physician-scientists. We hypothesize that early and longitudinal mentorship combined with development of research and professional development skills in the areas of Infectious Diseases and Immunology will make the physician-scientist career path attractive and sustainable. To this end, we propose the implementation of the MGH-Next Generation Physician-Scientist Training Pathways (MGH-Next Gen PSTP) program in Immunology and Infectious Disease. The MGH-Next Gen PSTP program is centered around the following objectives: Objective 1: Foster the creation of important scientific contributions through strong, longitudinal mentorship with an emphasis on leadership essentials. Objective 2: Develop sufficient basic laboratory and epidemiology approaches necessary to conduct high-quality research in the areas of immunology and infectious diseases. Objective 3: Formulate hypothesis-based research questions, development and execution of a research project, and effectively communicate the significance of their science. Together, these initiatives are designed to attract, train, and retain MDs in biomedical investigation at the most critical juncture of their career - residency training.

项目摘要 医生科学家在弥合基础科学和临床医生之间的差距方面发挥着独特的作用 通过识别重要的临床问题和翻译结果， 在乎不幸的是，医生科学家的劳动力继续减少，并有助于 对生物医学研究产生长期的负面影响。许多住院医师计划的重点 主要是获取医学知识，而不是培养求知欲和 进入生物医学研究领域。在这项建议中，我们的目的是提高吸引力， 并为在住院医师培训期间成为一名医生兼科学家做好准备。推动 对作为一名物理学家-科学家的职业兴趣的减少是识别令人鼓舞的 成功的导师有一个迫切需要重新强调既定的医生- 科学家作为学员的榜样。传染病和免疫学是基础领域 科学的发展，这极大地受益于一个强大的物理学家，科学家的劳动力。马萨诸塞州 总医院/哈佛医学院，特别是医学系和 外科，有一个长期的记录，培训医生科学家。我们假设早期和 纵向指导与研究和专业发展相结合 传染病和免疫学领域的技能将使医生科学家的职业生涯 具有吸引力和可持续性的道路。为此，我们建议实施MGH-Next 下一代物理学家-科学家培训途径（MGH-Next Gen PSTP）计划 免疫学和传染病。MGH-Next Gen PSTP计划围绕 目标如下： 目标1：通过强有力的， 纵向指导，强调领导力要素。 目标2：制定必要的充分的基本实验室和流行病学方法 在免疫学和传染病领域进行高质量的研究。 目标3：制定基于假设的研究问题，并制定和执行 一个研究项目，并有效地传达他们的科学意义。 这些举措旨在吸引、培训和留住生物医学领域的医学博士 在他们职业生涯中最关键的时刻进行调查-住院医师培训。

项目成果

Acute rejection in donation after circulatory death (DCD) heart transplants.

循环死亡（DCD）心脏移植后捐赠的急性排斥反应。

• DOI: 10.1016/j.healun.2023.09.004
• 发表时间: 2024
• 期刊: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
• 作者: Li,SelenaS;Funamoto,Masaki;Osho,AsishanaA;Rabi,SeyedA;Paneitz,Dane;Singh,Ruby;Michel,Eriberto;Lewis,GregoryD;D'Alessandro,DavidA
• 通讯作者: D'Alessandro,DavidA

The Heterogenous Effect of COVID-19 on Liver Transplantation Activity and Waitlist Mortality in the United States.

• DOI: 10.3389/fsurg.2021.669129
• 发表时间: 2021
• 期刊: Frontiers in surgery
• 影响因子: 1.8
• 作者: Yuan Q;Haque O;Coe TM;Markmann JF
• 通讯作者: Markmann JF

Current status of porcine islet xenotransplantation.

• DOI: 10.1097/mot.0000000000000794
• 发表时间: 2020-10
• 期刊: Current opinion in organ transplantation
• 影响因子: 2.2
• 作者: Coe TM;Markmann JF;Rickert CG
• 通讯作者: Rickert CG

Effective Senior Surgical Residents as Defined by Their Peers: A Qualitative Content Analysis of Nontechnical Skills Development.

同龄人定义的有效高级外科居民：非技术技能开发的定性内容分析。

• DOI: 10.1097/sla.0000000000005106
• 发表时间: 2023-03-01
• 期刊: Annals of surgery
• 影响因子: 9
• 作者: Coe TM;Jogerst KM;Petrusa E;Phitayakorn R;Lipman J
• 通讯作者: Lipman J

Drug reaction with eosinophilia and systemic symptoms (DRESS): clinical presentation and outcomes in people of color.

嗜酸性粒细胞增多和全身症状的药物反应（DRESS）：有色人种的临床表现和结果。

• DOI: 10.1016/j.jaip.2023.08.009
• 发表时间: 2023
• 期刊: The journal of allergy and clinical immunology. In practice
• 作者: Bassir,Fatima;Alvarez-Arango,Santiago;Kroshinsky,Daniela;Phillips,Elizabeth;Ezeofor,AdaezeJ;Samarakoon,Upeka;Blackley,SuzanneV;Wang,Liqin;Zhou,Li;Blumenthal,KimberlyG
• 通讯作者: Blumenthal,KimberlyG