Transdisciplinary Training In Cardiovascular Research

心血管研究的跨学科培训

• 批准号: 10671631
• 负责人: J Kevin Donahue
• 金额: $ 50.83万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10671631
• 关键词: Cardiovascular system; Research; Training

ABSTRACT We propose the 1st competitive renewal of our transdisciplinary cardiovascular sciences training program (CVT32) at the University of Massachusetts Medical School (UMMS). We will continue to encompass the full spectrum of cardiovascular (CV) research from basic to population health. This breadth is part of the UMMS culture of conducting science that makes a difference. The CVT32 is a collaboration between the Division of Cardiovascular Medicine in the Department of Medicine and the Department of Population and Quantitative Health Sciences (PQHS) and involves 48 participating faculty from multiple departments. Our two MPIs have different research expertise, with one (Freedman) more in the bench through phase 1 clinical trials arena and the other (Kiefe) in the phase 2/3 clinical trials (efficacy) through effectiveness, implementation, and population-sciences arena. Trainees will have mentoring teams with a lead mentor in their CV area of interest and a co-mentor plus an additional mentor-in-training representing very different areas of research. The synergism of our CVT32 faculty spanning the entire spectrum is a unique strength of our CVT32 enabling us to train scientists in a transdisciplinary way, with bidirectional hypothesis generation. Team mentoring and hands-on research experience through the entire training period are key components of our CVT32, together with structured coursework and abundant enrichment activities tailored to the individual trainee. We have a doctoral program and a Masters of Science of Clinical investigation housed in PQHS, where all CVT32 trainees will each have their own cubicle, in close physical proximity to researchers across the spectrum. Building on the success of our 1st funding period, we propose to enlarge the program by attaining a steady-state of 4 postdoctoral trainees and 4 predoctoral trainees at a time, with terms of 2-3 years; and newly adding a 12-week summer research training experiences for 8 medical students/year enrolled in a 4-year clinical and translational research pathway. Thus, our aims are to 1) Expand our successful CVT32 across basic, clinical, and population health sciences geared towards translating research into effective clinical practice and policy, and generating new questions spanning the entire spectrum of CV research. 2) Recruit pre-and post- doctoral trainees forming a diverse group regarding sociodemographics, clinical background, and disciplinary perspectives. 3) Provide trainees with the individual mentoring, academic training, and technical skills that will ensure their success as independent investigators as well as contributors to team science. 4) Provide “hands on” research experiences within transdisciplinary teams that build on the strengths of the current environment of linkages between UMMS Departments, Centers, and Institutes.

摘要 我们建议第一次竞争性更新我们的跨学科心血管科学培训。 项目(CVT32)在马萨诸塞大学医学院(UMMS)。我们将继续 涵盖从基础到人群健康的全方位心血管(CV)研究。这一广度 是密歇根州立大学进行科学研究的文化的一部分，这会带来不同的影响。CVT32是一种协作 内科心血管内科与内科 人口与定量健康科学(PQHS)，涉及来自多个国家的48名教职员工 各部门。 我们的两个MPI拥有不同的研究专业知识，其中一个(弗里德曼)通过 一期临床试验竞技场和另一期(Kiefe)2/3期临床试验(疗效)通过 有效性、实施性和人口科学领域。受训者将有指导团队 在他们感兴趣的简历领域有一名首席导师和一名共同导师，外加一名额外的培训导师 代表着非常不同的研究领域。我们的CVT32教职员工在整个 光谱是我们CVT32的独特优势，使我们能够以跨学科的方式培训科学家， 具有双向假设生成。通过以下途径获得团队指导和实践研究经验 整个培训期间是我们的CVT32的关键组成部分，以及结构化的课程和 为学员个人量身定做丰富的充实活动。我们有一个博士项目和一个 PQHS的临床调查科学硕士学位，所有CVT32名学员将在那里每人拥有 他们自己的隔间，在物理上非常接近不同光谱的研究人员。 在我们第一个资助期取得成功的基础上，我们建议通过实现 一次4名博士后实习生和4名博士后实习生，期限2-3年； 并新增了每年8名医学生为期12周的暑期科研培训经验 参加为期4年的临床和转化性研究课程。 因此，我们的目标是1)将我们成功的CVT32扩展到基础、临床和人群健康 旨在将研究转化为有效的临床实践和政策的科学，并产生 横跨简历研究整个领域的新问题。2)招募博士后和博士后实习生 形成关于社会人口学、临床背景和学科的不同群体 透视。3)为学员提供个人指导、学术培训和技术技能 这将确保他们作为独立研究人员和团队科学贡献者的成功。4) 在具有以下优势的跨学科团队中提供“实践”研究经验 UMMS部门、中心和研究所之间当前的联系环境。

项目成果

Interest in and barriers to participation in a Facebook-delivered weight loss program among female cancer survivors with overweight or obesity.

• DOI: 10.21037/mhealth.2019.08.02
• 发表时间: 2019-01-01
• 期刊: mHealth
• 作者: May, Christine N;Jake-Schoffman, Danielle E;Pritschmann, Ricarda K
• 通讯作者: Pritschmann, Ricarda K

Usefulness of Self-Reported Physical Activity and Clinical Outcomes in Older Patients With Atrial Fibrillation.

• DOI: 10.1016/j.amjcard.2022.07.010
• 发表时间: 2022-10-15
• 期刊: AMERICAN JOURNAL OF CARDIOLOGY
• 影响因子: 2.8
• 作者: Dai, Qiying;Mehawej, Jordy;Saczynski, Jane S.;Khanh-Van Tran;Abu, Hawa O.;Lessard, Darleen;Fillippaios, Andreas;Paul, Tenes;Hariri, Essa;Wang, Weijia;Tisminetzky, Mayra;Soni, Apurv;Howard-Wilson, Sakeina;Waring, Molly E.;Goldberg, Robert J.;McManus, David D.
• 通讯作者: McManus, David D.

Perceived weight status and weight change among a U.S. adult sample.

美国成人样本中的感知体重状况和体重变化。

• DOI: 10.1002/oby.21685
• 发表时间: 2017
• 期刊: Obesity (Silver Spring, Md.)
• 作者: Wang,MonicaL;Haughton,ChristinaF;Frisard,Christine;Pbert,Lori;Geer,Christine;Lemon,StephenieC
• 通讯作者: Lemon,StephenieC

Chromatin Compaction in Noncompaction Cardiomyopathy.

非致密化心肌病中的染色质致密化。

• DOI: 10.1161/circresaha.123.323015
• 发表时间: 2023
• 期刊: Circulation research
• 影响因子: 20.1
• 作者: Cashman,TimothyJ;Trivedi,ChinmayM
• 通讯作者: Trivedi,ChinmayM

Index of cardiometabolic health: a new method of measuring allostatic load using electronic health records.

• DOI: 10.1080/1354750x.2016.1201535
• 发表时间: 2017-07
• 期刊: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
• 作者: Nobel L;Roblin DW;Becker ER;Druss BG;Joski PI;Allison JJ
• 通讯作者: Allison JJ