Knowledge Base and Portal

知识库和门户

• 批准号: 10676276
• 负责人: Lang Li
• 金额: $ 96.46万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676276
• 关键词: 7alpha hydroxylase; ABCB1 gene; Academia; Acceleration; Active Learning; Adult; Affect; American; Animals; Artificial Intelligence; Birth; Body Water; CYP1A2 gene; CYP2C19 gene; CYP2C9 gene; CYP2D6 gene; CYP3A4 gene; CYP3A5 gene; Child; Childhood; Classification; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Common Data Element; Communities; Cytochrome P450; Data; Data Sources; Dehydroepiandrosterone Sulfate; Development; Devices; Disease; Dose; Drug Kinetics; Drug Metabolic Detoxication; Drug Receptors; Drug toxicity; Education; Enzymes; Excretory function; Fathers; Fetal Liver; Fetus; Glucuronosyltransferase; Growth; Human; Indiana; Industry; Infant; Isoenzymes; Kidney; Knowledge; Knowledge Portal; Lactation; Literature; Location; Maternal Physiology; Metabolism; Modeling; Ohio; Ontology; Pediatrics; Performance; Pharmaceutical Preparations; Pharmacodynamics; Pharmacoepidemiology; Pharmacogenetics; Pharmacogenomics; Pharmacology; Pharmacology and Toxicology; Pharmacotherapy; Phase; Physiological; Population; Pregnancy; Process; Property; Protein Isoforms; Publishing; Reporting; Research; Research Priority; Resources; Retinoids; Sample Size; Tablets; Technology; Teratogens; Text; Therapeutic; Therapeutic Research; Training; Translational Research; Tubular formation; Universities; Uridine Diphosphate; Visualization software; Woman; Work; absorption; classification algorithm; clinical investigation; data access; data curation; data dissemination; data mining; data portal; data sharing; data visualization; deep learning; disability; drug clearance; drug development; drug disposition; drug distribution; drug efficacy; drug metabolism; extracellular; gender difference; graphical user interface; improved; innovation; knowledge base; knowledgebase; men; neonate; novel; ontology development; open source; outreach; pediatric patients; pharmacometrics; portability; pregnant; research and development; response; web portal

Summary (Knowledgebase and Portal Core) The Knowledgebase and Portal Core (KPC) of the Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC) will develop a knowledgebase and web portal of data and resources relating to maternal and pediatric therapeutics. The KPC will collaborate with Pharmacometrics and Clinical Trial Design Core, Real- World Evidence Core, and other collaborators to support common data elements and ontology development, knowledgebase construction, and web portal development. The Aims of the KPC will be 1) to develop common data elements and ontology for annotating pharmacology data in children and pregnant/lactating women, including those with disabilities; (2) Develop text classification algorithms to identify published literature in pediatric and pregnant/lactating women; (3) Integrate various data sources relating to pharmacokinetics, pharmacodynamics, pharmacogenetics, pediatric ontogeny and the physiological changes that occur with and around pregnancy and lactation that influence drug metabolism, distribution, and drug response; pharmacogenomics, pharmacometrics modeling; and drug toxicity and efficacy in maternal and pediatric populations; (4) Develop a data portal for knowledge data sharing and dissemination. The KPC will work with the MPRINT Hub Steering Committee to set research priorities and milestones and with the Outreach, Dissemination and Training Core to disseminate results and provide education on pharmacometric approaches applied to maternal and pediatric therapeutic research.

摘要（知识库和门户核心）