The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC)

印第安纳大学-俄亥俄州立大学母婴精准治疗数据、模型、知识和研究协调中心 (IU-OSU MPRINT DMKRCC)

• 批准号: 10584124
• 负责人: Lang Li
• 金额: $ 97.48万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10584124
• 关键词: Advocate; Awareness; Bioethics Consultants; Biological; Biological Availability; Biological Markers; Biological Specimen Banks; Child; Childhood; Clinical Data; Clinical Management; Clinical Research; Collaborations; Communities; Consent Forms; Data; Databases; Development; Diagnosis; Disease; Evolution; Focus Groups; Foundations; Funding; Funding Agency; Future; Goals; Hand; Human Resources; Incidence; Indiana; Individual; Infrastructure; Interdisciplinary Study; Intervention; Knowledge; Legal; Link; Longitudinal Studies; Longterm Follow-up; Maternal and Child Health; Maternal complication; Modeling; Morbidity - disease rate; Mothers; Neonatal; Ohio; Outcome; Patients; Pediatric Research; Perinatal; Population; Pre-Eclampsia; Precision therapeutics; Pregnancy; Professional counselor; Rare Diseases; Regulation; Research; Research Personnel; Residual state; Resources; Risk; Sample Size; Sampling; Site; Source; Specimen; Surveys; Therapeutic; Therapeutic Human Experimentation; Therapeutic Studies; TimeLine; Translational Research; Translations; United States National Institutes of Health; Universities; Woman; Work; biobank; clinical phenotype; data dictionary; data integration; data repository; data resource; early onset; early pregnancy; fetal; high risk; innovation; mortality; novel therapeutic intervention; pediatric patients; perinatal period; pregnant; prevent; prospective; rare condition; recruit; repository; research study; response; translational scientist; user-friendly; web site; working group

Project Summary/Abstract Early-onset, or preterm, preeclampsia occurs in only 0.5% of pregnancies, but it is associated with a high risk of long- term maternal complications, as well as high fetal morbidity and mortality. Biomarkers associated with early-onset preeclampsia are needed to identify women at risk of developing early-onset preeclampsia, guide treatment options, and support development of new therapeutic approaches to prevent and treat the disease. Additionally, it is important to understand the long-term consequences of preterm preeclampsia in both the mother and child. However, due to the low incidence of early-onset preeclampsia, it is difficult to obtain data and necessary biospecimens from a sufficient number of women through a single center or study. Whether collected as a prospective biobanking endeavor or leftover residual samples from clinical studies, numerous biospecimens from maternal and pediatric patients reside within storage facilities across the world. These untapped biosamples and their associated data have the potential to greatly enhance maternal and pediatric therapeutics research, especially for rare conditions and diseases such as early-onset preeclampsia. However, there is no single resource to identify sources of maternal and pediatric biospecimens, so often translational researchers seeking such samples may not be aware of their existence. This proposal will characterize the landscape of available maternal and pediatric biospecimens and survey investigators to understand the needs of the translational research community. We will develop The Collaborative Online Perinatal & PEdiatric Repository (COPPER), a user-friendly platform to facilitate identification of biobanks and networks with residual biospecimens available to support maternal and pediatric precision therapy research. Through surveys and working group discussions, we will seek to understand the evolution of regulations relating to future use of biospecimens and propose strategies to enhance the ability to link long-term pediatric outcomes to samples collected during the perinatal period. At the end of this project, we will develop a centralized resource providing information on biorepositories which could support maternal and pediatric translational research and precision therapeutics, develop proposals to enhance the ability to link maternal and child data and specimens, and identify biospecimens and associated clinical data to support future work to develop biomarkers and therapeutic approaches to prevent and treat early-onset preeclampsia.

项目总结/文摘