Knowledge Base and Portal

摘要（知识库和门户核心） 印第安纳州-俄亥俄州立大学的知识库和门户核心（KPC） 儿科治疗数据、模型、知识和研究协调中心（IU-OSU） MPRINT DMKRCC）将开发一个知识库和门户网站，提供与孕产妇保健有关的数据和资源。 和儿科治疗学。KPC将与药物计量学和临床试验设计核心，真实的- World Evidence Core和其他合作者支持公共数据元素和本体开发， 知识库建设和门户网站开发。科索沃保护团的目标是：1）发展共同的 用于注释儿童和孕妇/哺乳期妇女的药理学数据的数据元素和本体， 包括残疾人;（2）开发文本分类算法，以识别已发表的文献， 儿科和孕妇/哺乳期妇女;（3）整合与药代动力学相关的各种数据源， 药效学，药物遗传学，儿科个体发育和生理变化， 妊娠期和哺乳期影响药物代谢、分布和药物反应; 药物基因组学、药物计量学建模;以及药物毒性和在孕产妇和儿童中的疗效 （4）开发一个数据门户网站，以分享和传播知识数据。科索沃保护团将与 MPRINT中心指导委员会设定研究优先事项和里程碑，并与外联， 传播和培训核心：传播结果并提供关于药物计量学方法的教育 应用于母婴治疗研究。

Summary (Knowledgebase and Portal Core) The Knowledgebase and Portal Core (KPC) of the Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC) will develop a knowledgebase and web portal of data and resources relating to maternal and pediatric therapeutics. The KPC will collaborate with Pharmacometrics and Clinical Trial Design Core, Real- World Evidence Core, and other collaborators to support common data elements and ontology development, knowledgebase construction, and web portal development. The Aims of the KPC will be 1) to develop common data elements and ontology for annotating pharmacology data in children and pregnant/lactating women, including those with disabilities; (2) Develop text classification algorithms to identify published literature in pediatric and pregnant/lactating women; (3) Integrate various data sources relating to pharmacokinetics, pharmacodynamics, pharmacogenetics, pediatric ontogeny and the physiological changes that occur with and around pregnancy and lactation that influence drug metabolism, distribution, and drug response; pharmacogenomics, pharmacometrics modeling; and drug toxicity and efficacy in maternal and pediatric populations; (4) Develop a data portal for knowledge data sharing and dissemination. The KPC will work with the MPRINT Hub Steering Committee to set research priorities and milestones and with the Outreach, Dissemination and Training Core to disseminate results and provide education on pharmacometric approaches applied to maternal and pediatric therapeutic research.