The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC)
印第安纳大学-俄亥俄州立大学母婴精准治疗数据、模型、知识和研究协调中心 (IU-OSU MPRINT DMKRCC)
基本信息
- 批准号:10309155
- 负责人:
- 金额:$ 300万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-10 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAdultBest Pharmaceuticals for Children ActBreast FeedingChildChildhoodChronicClinicalClinical ResearchClinical TrialsClinical Trials DesignCommunitiesComplexConsumptionDataDatabasesDevelopmentDrug KineticsDrug usageEducational ActivitiesEnrollmentEthicsExclusive BreastfeedingFDA approvedFeedbackFetusFosteringFundingGoalsGuidelinesHealthIncentivesIndianaIndividualInfantInfrastructureInstitute of Medicine (U.S.)KnowledgeKnowledge PortalLabelLactationLiteratureLogisticsMilkMissionModelingModernizationNational Institute of Child Health and Human DevelopmentNeonatalOhioOrphanOutcomePediatric ResearchPharmaceutical PreparationsPharmacologic SubstancePharmacologyPharmacotherapyPhysiologyPopulationPregnancyPregnant WomenResearchResearch DesignResearch SupportResourcesRheumatoid ArthritisRiskScienceSourceTherapeuticTherapeutic AgentsTimeLineTranslational ResearchUnited States Food and Drug AdministrationUnited States National Institutes of HealthUniversitiesVulnerable PopulationsWomanWomen&aposs HealthWorkbasecohesiondata sharingdrug developmentdrug dispositiondrug distributiondrug efficacyimprovedinfant morbidity/mortalityknowledge baseknowledge integrationmaternal morbiditymedication safetymeetingsmenmultidisciplinaryneonateorganizational structureoutreachpediatric patientspersonalized medicinepharmacokinetics and pharmacodynamicspharmacometricsphysiologically based pharmacokineticsprogramsresearch studyresponseweb portalwebinar
项目摘要
Summary (Overall)
The Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub will serve as a national resource for multi-
disciplinary expertise and knowledge in maternal and pediatric therapeutics. The MPRINT Data, Model,
Knowledge, and Research Coordination Center (DMKRCC) will support the MPRINT Centers of Excellence in
Therapeutics (CET) and Steering Committee to coordinate and expand research relating to maternal and
pediatric therapeutics. The DMKRCC will serve as the administrative component of the MPRINT Hub, coordinate
outreach and dissemination of MPRINT Hub activities, and will serve as a conduit between the MPRINT Hub
and the broader scientific community. Additionally, the MPRINT DMKRCC will organize annual MPRINT
meetings and educational activities, including webinars, to cultivate translational research in maternal and
pediatric therapeutics. The DMKRCC will identify, aggregate, and make available data, knowledge, and expertise
in maternal and pediatric therapeutics to the wider research, drug development, and regulatory communities.
Specifically, the DMKRCC will identify, evaluate, and collate pertinent data in a knowledgebase that will be made
available through a web portal; utilize and enhance pharmacometric modeling approaches such as
physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD); support clinical trial design; and
foster expertise in drug development and personalized therapy for maternal and pediatric populations. The
specific aims of this proposal will develop a cohesive organizational structure to support the research of the
MPRINT Hub as a whole as well as the individual cores within the DMKRCC. We will develop infrastructure to
facilitate data sharing and knowledge dissemination, and work with the CETs and Steering Committee to identify
and address changing needs of the maternal and pediatric communities.
总结(总体)
孕产妇和儿科治疗精确度(MPRINT)中心将作为国家资源,
在孕产妇和儿科治疗学方面的专业知识和知识。MPRINT数据,模型,
知识和研究协调中心(DMKRCC)将支持MPRINT卓越中心,
治疗学(CET)和指导委员会,以协调和扩大与孕产妇和
儿科治疗学DMKRCC将作为MPRINT中心的行政组成部分,协调
推广和传播MPRINT Hub活动,并将作为MPRINT Hub之间的渠道
以及更广泛的科学界。此外,MPRINT DMKRCC将组织年度MPRINT
会议和教育活动,包括网络研讨会,以促进孕产妇和
儿科治疗学DMKRCC将识别、汇总并提供数据、知识和专业知识
在孕产妇和儿科治疗更广泛的研究,药物开发和监管社区。
具体而言,DMKRCC将在知识库中识别、评估和整理相关数据,
可通过门户网站获得;利用和增强药理学建模方法,
基于生理学的药代动力学和药效学(PBPK/PD);支持临床试验设计;以及
培养药物开发和针对孕产妇和儿童群体的个性化治疗方面的专业知识。的
该提案的具体目标是建立一个有凝聚力的组织结构,以支持联合国的研究。
MPRINT Hub作为一个整体以及DMKRCC中的各个核心。我们将发展基础设施,
促进数据共享和知识传播,并与CET和指导委员会合作,
并满足孕产妇和儿科社区不断变化的需求。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Lang Li', 18)}}的其他基金
The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC)
印第安纳大学-俄亥俄州立大学母婴精准治疗数据、模型、知识和研究协调中心 (IU-OSU MPRINT DMKRCC)
- 批准号:
10584124 - 财政年份:2022
- 资助金额:
$ 300万 - 项目类别:
The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC)
印第安纳大学-俄亥俄州立大学母婴精准治疗数据、模型、知识和研究协调中心 (IU-OSU MPRINT DMKRCC)
- 批准号:
10487575 - 财政年份:2021
- 资助金额:
$ 300万 - 项目类别:
The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC)
印第安纳大学-俄亥俄州立大学母婴精准治疗数据、模型、知识和研究协调中心 (IU-OSU MPRINT DMKRCC)
- 批准号:
10676275 - 财政年份:2021
- 资助金额:
$ 300万 - 项目类别:
An informatics bridge over the valley of death for cancer Phase I trials of drug-combination therapies
跨越癌症死亡之谷的信息学桥梁 药物组合疗法的 I 期试验
- 批准号:
10494095 - 财政年份:2021
- 资助金额:
$ 300万 - 项目类别:
An informatics bridge over the valley of death for cancer Phase I trials of drug-combination therapies
跨越癌症死亡之谷的信息学桥梁 药物组合疗法的 I 期试验
- 批准号:
10305083 - 财政年份:2021
- 资助金额:
$ 300万 - 项目类别:
A Translational Bioinformatics Approach in the Drug Interaction Research
药物相互作用研究中的转化生物信息学方法
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8761156 - 财政年份:2014
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A Translational Bioinformatics Approach in the Drug Interaction Research
药物相互作用研究中的转化生物信息学方法
- 批准号:
8913218 - 财政年份:2014
- 资助金额:
$ 300万 - 项目类别:
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