The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC)

摘要(总体) 母婴治疗精确度中心(MPRINT)将作为一个全国性的资源，为多个 母婴治疗学的专业知识和专业知识。MPRINT数据、型号、 知识、研究和协调中心(DMKRCC)将支持MPRINT英才中心 治疗学(CET)和指导委员会协调和扩大与孕产妇和 儿科治疗学。DMKRCC将作为MPRINT中心的行政部门，协调 外联和传播MPRINT中心的活动，并将作为MPRINT中心之间的渠道 以及更广泛的科学界。此外，MPRINT DMKRCC将组织年度MPRINT 会议和教育活动，包括网络研讨会，以培养产妇和妇女的翻译研究 儿科治疗学。DMKRCC将识别、汇总并提供可用的数据、知识和专业知识 在母婴治疗学领域向更广泛的研究、药物开发和监管社区提供帮助。 具体地说，DMKRCC将识别、评估和整理知识库中的相关数据 可通过Web门户获得；利用和增强药物计量建模方法，例如 基于生理的药代动力学和药效学(PBPK/PD)；支持临床试验设计；以及 培养针对孕产妇和儿科人群的药物开发和个性化治疗方面的专门知识。这个 这项提案的具体目标将形成一个连贯的组织结构，以支持对 MPRINT集线器作为一个整体以及DMKRCC内的各个核心。我们将发展基础设施，以 促进数据共享和知识传播，并与CETS和指导委员会合作，以确定 并满足产妇和儿科社区不断变化的需求。

Summary (Overall) The Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub will serve as a national resource for multi- disciplinary expertise and knowledge in maternal and pediatric therapeutics. The MPRINT Data, Model, Knowledge, and Research Coordination Center (DMKRCC) will support the MPRINT Centers of Excellence in Therapeutics (CET) and Steering Committee to coordinate and expand research relating to maternal and pediatric therapeutics. The DMKRCC will serve as the administrative component of the MPRINT Hub, coordinate outreach and dissemination of MPRINT Hub activities, and will serve as a conduit between the MPRINT Hub and the broader scientific community. Additionally, the MPRINT DMKRCC will organize annual MPRINT meetings and educational activities, including webinars, to cultivate translational research in maternal and pediatric therapeutics. The DMKRCC will identify, aggregate, and make available data, knowledge, and expertise in maternal and pediatric therapeutics to the wider research, drug development, and regulatory communities. Specifically, the DMKRCC will identify, evaluate, and collate pertinent data in a knowledgebase that will be made available through a web portal; utilize and enhance pharmacometric modeling approaches such as physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD); support clinical trial design; and foster expertise in drug development and personalized therapy for maternal and pediatric populations. The specific aims of this proposal will develop a cohesive organizational structure to support the research of the MPRINT Hub as a whole as well as the individual cores within the DMKRCC. We will develop infrastructure to facilitate data sharing and knowledge dissemination, and work with the CETs and Steering Committee to identify and address changing needs of the maternal and pediatric communities.