Shared Resource 01: Biomedical Informatics (BISR)

项目摘要-生物信息学共享资源（BISR） BISR是一个重要的共享资源，支持广泛的生物信息学研究， 计算生物学需求，从下一代测序（NGS）到人口数据管理 科学研究。BISR位于BMI部门内，其目标是利用各种信息学 服务，从组学数据集的分析到以患者/参与者为中心的数据仪器，访问， 以及管理工具和流程。BSR的具体目标是：1）提供最先进的 生物信息学和计算生物学服务; 2）为OSUCCC研究者提供服务， 专业知识和获得技术平台，以支持异构和多维生物医学 数据管理要求。在当前的资助周期内，Kevin Coombes博士（TT）和Lang Li博士（CB） 接替Philip Payne博士和Jeffrey Parvin博士担任BISR的领导。在本供资周期， 为生物医学信息学系（BMI）建立了谅解备忘录（MOU）， OSUCCC将在BISR内以每年10%的费用支持5名教师，为期3年，因为他们过渡到赠款资助， 滚动基础，为OSUCCC会员提供不收费的、以癌症为重点的生物信息学工作，和/或 癌症研究人员。BISR的其他主要变化包括支持增强 基因组学共享资源（GSR）将新开发的共享服务与全国儿童基金会（Nationwide Children's） 医院（NCH）;并增加了支持涉及单细胞测序数据的研究的能力， （第三代）测序、代谢组学和宏基因组学。BISR增加了五名新教师，以支持 （1）药物敏感性预测的计算优化（Cheng），（2）蛋白质组学和功能 DNA非编码区注释（Zhang），（3）代谢组学和宏基因组学（Mathe），（4）单细胞 测序（Ma），和（5）长读序测序（Au）。BISR支持的生物样本服务共享资源 （BSSR）项目（全面癌症护理[TCC]和肿瘤学研究信息交流网络[ORIEN]） 通过建立一个带有去识别数据的患者记录数据仓库。在本供资周期内， BISR支持了115篇出版物（25篇> 10影响因子），134个用户和32个NCI赠款，包括5个P01，2个P50， 13个R 01、3个R21、1个R50、2个U 01、1个U10、1个UG 1，涉及所有五个方案的成员。在下一次拨款时 BISR将加强“智能化”服务，例如，整合不同来源的组学和 临床数据。BISR将成为免疫监测和发现平台（IMDP）的重要组成部分， 促进复杂免疫肿瘤学项目共享资源之间互动的方法。年度 BISR的预算为1，122，279美元，而CCSG的要求为106，905美元。因此，BISR利用了广泛的 机构支持，仅寻求CCSG资金的9.5%支持。

PROJECT SUMMARY – BIOINFORMATICS SHARED RESOURCE (BISR) The BISR is an essential shared resource that supports a wide range of studies with bioinformatics and computational biology needs, ranging from next generation sequencing (NGS) to data management in population science studies. Housed within the Department of BMI, the BISR's goal is to leverage a variety of informatics services, ranging from analysis of omics datasets to patient/participant-centered data instrumentation, access, and management tools and processes. The Specific Aims of the BSR are to: 1) Provide state of the art bioinformatics and computational biology services; and 2) Provide OSUCCC investigators with services, expertise and access to technology platforms in support of heterogeneous and multi-dimensional biomedical data management requirements. Over the current grant cycle, Drs. Kevin Coombes (TT) and Lang Li (CB) assumed leadership of BISR, replacing Drs. Philip Payne and Jeffrey Parvin. During the current funding cycle, a Memorandum of Understanding (MOU) was established for the Department of Biomedical Informatics (BMI) and the OSUCCC to support 5 faculty at 10% per year for 3 years within BISR as they transition to grant funding, on a rolling basis, to provide non-chargeable, cancer focused bioinformatics work for OSUCCC membership and/or cancer focused researchers. Additional major changes for BISR include supporting the enhancement of the Genomics Shared Resource (GSR) to incorporate newly developed shared services with Nationwide Children's Hospital (NCH); and added capabilities to support studies involving data from single-cell sequencing, long-read (third generation) sequencing, metabolomics, and metagenomics. BISR has added five new faculty to support the areas of (1) computational optimization for drug sensitivity prediction (Cheng), (2) proteomics, and functional annotation of DNA non-coding regions (Zhang), (3) metabolomics and metagenomics (Mathe), (4) single-cell sequencing (Ma), and (5) long-read sequencing (Au). BISR supported Biospecimen Services Shared Resource (BSSR) projects (Total Cancer Care [TCC] and the Oncology Research Information Exchange Network [ORIEN]) by establishing a data warehouse of patient records with de-identified data. During the current funding cycle, the BISR supported 115 publications (25 > 10 impact factor), 134 users, and 32 NCI grants including 5 P01s, 2 P50s, 13 R01s, 3 R21s, 1 R50, 2 U01s, 1 U10, 1 UG1, involving members from all five programs. Over the next grant cycle, BISR will enhance services for “integromics”, e.g., the integration of disparate source of both omics and clinical data. BISR will be a critical part of the Immune Monitoring and Discovery Platform (IMDP), an overarching approach for fostering interactions among shared resources for complex immuno-oncology projects. The annual budget of the BISR is $1,122,279, yet the CCSG request is $106,905. As such, the BISR leverages extensive institutional support and seeks only 9.5% support from CCSG funds.