CC: Biostatistics Core

孢子核心C：生物统计学核心。德克萨斯大学提出的肺孢子学研究 癌症包括广泛的活动，包括对细胞系、动物模型和临床的研究。 审判。这些研究将产生许多不同类型的数据，不仅包括传统的临床数据， 流行病学、生化和免疫组织化学测量，还有剂量反应曲线， 基因表达微阵列、反相蛋白裂解物阵列(RPPA)、细胞因子分析和 单核苷酸多态(SNPs)频率的评估。生物统计核心提供 全面的生物统计学专业知识，以确保统计的完整性和优化数据分析 由孢子进行的研究，在西南医学中心(UTSW)和M.D. 安德森癌症中心(MDACC)。核心协助调查人员进行适当的实验计划， 与Core D(生物信息学)合作管理肺孢子项目产生的实验数据， 并为肺孢子调查人员进行统计分析。酷睿拥有匹配的灵活性 根据现有和发展中的孢子项目的不断变化的需要，教科文组织将继续为现有和发展中的孢子项目增加人员。核心成员 参加每月一次的孢子视频会议，将德克萨斯州达拉斯和马里兰州UTSW的研究人员联系起来。 德克萨斯州休斯敦的安德森癌症中心，有时也是其他机构的研究人员(例如 得克萨斯州，奥斯汀)，确保适当考虑生物统计和数据管理问题 在孢子实验的所有阶段。为履行其职责，核心有以下几点 具体目标： 目的1：为实验室研究、临床试验和转化实验提供有效的统计设计 产生于对孢子的正在进行的研究。 目标2：监督和执行所需的创新性统计建模、模拟和数据分析 通过项目、发展项目和职业项目等核心来实现各自的具体目标。 目标3：确保所有项目的结果都以精心设计的实验为基础，适当地 翻译，并协助编写描述这些成果的手稿。 目标4：在综合数据库的配置方面与核心D(生物信息学)密切合作 应用程序编程接口(API)，以促进统计分析程序和 开发计算工具，并向所有孢子参与者提供这些工具。

SPORE Core C: Biostatistics Core. The research proposed by The University of Texas SPORE in Lung Cancer encompasses a broad range of activities, including studies in cell lines, animal models, and clinical trials. These studies will generate many different types of data, including not only conventional clinical, epidemiological, biochemical, and immunohistochemical measurements, but also dose response curves, gene expression microarrays, reverse phase protein lysate arrays (RPPA), cytokine assays, and assessments of the frequency of single nucleotide polymorphisms (SNPs). The Biostatistics Core provides comprehensive biostatistics expertise to ensure the statistical integrity and to optimize data analysis of the studies by the SPORE, which are conducted at the Southwestern Medical Center (UTSW) and the M.D. Anderson Cancer Center (MDACC). The Core assists investigators with the proper planning of experiments, cooperates with Core D (Bioinformatics) to manage experimental data generated by Lung SPORE projects, and conducts statistical analyses for Lung SPORE investigators. The Core has the flexibility to match personnel to the evolving needs of existing and developmental SPORE projects. Members of the Core participate in monthly SPORE video conferences linking researchers at UTSW in Dallas, TX and M.D. Anderson Cancer Center in Houston, TX, and at times investigators at other institutions (e.g. University of Texas, Austin), ensuring that proper consideration is taken of biostatistics and data management issues during all phases of SPORE experiments. To carry out its responsibilities, the Core has the following Specific Aims: Aim 1: To provide valid statistical designs of laboratory research, clinical trials and translational experiments arising from the ongoing research of the SPORE. Aim 2: To oversee and conduct the innovative statistical modeling, simulations, and data analyses needed by the Projects, Developmental and Career Projects, and the other Cores to achieve their specific aims. Aim 3: To ensure that the results of all Projects are based on well-designed experiments, appropriately interpreted, and to assist in the preparation of manuscripts describing these results. Aim 4: To work closely with Core D (Bioinformatics) in the configuration of the integrated database application programming interface (API) to facilitate automation of statistical analysis procedures and development of computational tools, and make them available to all SPORE participants.