CC: Biostatistics Core

孢子核心C：生物统计学核心。德克萨斯大学的SPORE在肺中提出的研究 癌症包括广泛的活动，包括细胞系研究、动物模型和临床研究。 审判这些研究将产生许多不同类型的数据，不仅包括传统的临床， 流行病学、生物化学和免疫组织化学测量，以及剂量反应曲线， 基因表达微阵列、反相蛋白裂解物阵列（RPPA）、细胞因子测定和 单核苷酸多态性（SNP）频率的评估。生物统计学核心提供 全面的生物统计学专业知识，以确保统计完整性和优化数据分析， 研究由SPORE，这是在西南医学中心（UTSW）和医学博士进行。 安德森癌症中心（MDACC）。核心协助研究人员进行适当的实验计划， 与Core D（生物信息学）合作管理Lung SPORE项目生成的实验数据， 并为肺孢子研究者进行统计分析。Core具有与之相匹配的灵活性 人员的现有和发展的SPORE项目不断变化的需求。核心成员 参加每月一次的SPORE视频会议，将德克萨斯州达拉斯的UTSW和马里兰州的研究人员联系起来。 德克萨斯州休斯顿的安德森癌症中心的研究人员以及其他机构（例如， 得克萨斯州，奥斯汀），确保适当考虑生物统计和数据管理问题 在SPORE实验的所有阶段。为了履行其职责，核心有以下几点： 具体目标： 目的1：为实验室研究、临床试验和转化实验提供有效的统计设计 这是由SPORE正在进行的研究引起的。 目标2：监督和进行所需的创新统计建模、模拟和数据分析 通过项目、发展和职业项目以及其他核心来实现其特定目标。 目标3：确保所有项目的结果都基于精心设计的实验， 解释，并协助编写描述这些结果的手稿。 目标4：与核心D（生物信息学）密切合作，配置综合数据库 应用程序编程接口（API），以促进统计分析程序的自动化， 开发计算工具，并将其提供给所有SPORE参与者。

SPORE Core C: Biostatistics Core. The research proposed by The University of Texas SPORE in Lung Cancer encompasses a broad range of activities, including studies in cell lines, animal models, and clinical trials. These studies will generate many different types of data, including not only conventional clinical, epidemiological, biochemical, and immunohistochemical measurements, but also dose response curves, gene expression microarrays, reverse phase protein lysate arrays (RPPA), cytokine assays, and assessments of the frequency of single nucleotide polymorphisms (SNPs). The Biostatistics Core provides comprehensive biostatistics expertise to ensure the statistical integrity and to optimize data analysis of the studies by the SPORE, which are conducted at the Southwestern Medical Center (UTSW) and the M.D. Anderson Cancer Center (MDACC). The Core assists investigators with the proper planning of experiments, cooperates with Core D (Bioinformatics) to manage experimental data generated by Lung SPORE projects, and conducts statistical analyses for Lung SPORE investigators. The Core has the flexibility to match personnel to the evolving needs of existing and developmental SPORE projects. Members of the Core participate in monthly SPORE video conferences linking researchers at UTSW in Dallas, TX and M.D. Anderson Cancer Center in Houston, TX, and at times investigators at other institutions (e.g. University of Texas, Austin), ensuring that proper consideration is taken of biostatistics and data management issues during all phases of SPORE experiments. To carry out its responsibilities, the Core has the following Specific Aims: Aim 1: To provide valid statistical designs of laboratory research, clinical trials and translational experiments arising from the ongoing research of the SPORE. Aim 2: To oversee and conduct the innovative statistical modeling, simulations, and data analyses needed by the Projects, Developmental and Career Projects, and the other Cores to achieve their specific aims. Aim 3: To ensure that the results of all Projects are based on well-designed experiments, appropriately interpreted, and to assist in the preparation of manuscripts describing these results. Aim 4: To work closely with Core D (Bioinformatics) in the configuration of the integrated database application programming interface (API) to facilitate automation of statistical analysis procedures and development of computational tools, and make them available to all SPORE participants.