Patient Oriented Research and Mentorship in Childhood Obesity Disparities

项目摘要 儿童期肥胖对发病率造成了很大负担，是心血管疾病的主要危险因素。 疾病种族和族裔少数群体以及来自弱势背景的儿童遭受不成比例的 国家肥胖负担的份额。尽管儿童肥胖症的干预措施已被证明是有效的 有效的干预措施没有得到充分利用，在采用 在照顾低收入儿童和高生育负担人口的环境中采用循证做法， 社会风险因素。此K24更新应用程序将支持以股权为重点的实施研究， 改善临床医生和家庭对有效儿童肥胖干预措施的采用， 低收入、种族/少数民族儿童的肥胖差异。此应用程序将利用 新资助的NHLBI R 01实施研究补助金，以优化健康连接的整合 儿科体重管理干预在儿科初级保健设置。在NHLBI的资助下，我们 测试将支持在卫生部门实施“连接健康”的关键适应措施和战略 马萨诸塞州为低收入儿童提供护理的护理系统。K24资金将允许PI和她 学员通过研究一种新的适应方法来扩展和扩大NHLBI研究：使用社会和 社区风险知情的肥胖护理计划，以增加儿童肥胖干预措施的影响， 肥胖的结果。此K24更新应用程序的总体目标是提供Elsie Taveras MD，MPH 有受保护的时间作为初级临床研究者的导师，帮助他们成为 独立的以患者为导向的研究人员，并支持新的科学目标，将建立在博士。 在儿童肥胖、健康差距和以公平为重点的执行科学方面开展了既定工作。博士 塔弗拉斯是哈佛医学院和哈佛T. H.的儿科和营养学教授。禅宗 公共卫生，和一个儿科肥胖专家在马萨诸塞州儿童总医院。她领导 几项大型的以患者为导向的研究，包括一项由NHLBI资助的实施研究， 作为她提出的目标的基础。Taveras博士已经成功地担任了更多的研究导师 40多名医学博士和博士候选人和临床医生在培训。她最初的K24专注于了解 儿童肥胖差异的背景根源，并制定干预措施，以预防和管理肥胖。 这个K24更新奖是这项工作的自然延伸，并将重点转移到转化研究， 执行科学。K24的更新将提高Taveras博士在以下领域的研究生产力： 儿童肥胖的差异，并通过她帮助促进青少年儿童肥胖科学家的职业生涯 导师制这项K24应用的拟议科学目标将有助于加强Taveras博士的能力， 在以患者为导向的研究中为初级研究人员提供指导，重点是以公平为中心 实施研究，以改善儿童肥胖干预措施的采用和效果。

Project Abstract Childhood obesity represents a substantial burden on morbidity and is a major risk factor for cardiovascular disease. Racial and ethnic minorities and children from disadvantaged backgrounds suffer a disproportionate share of the national obesity burden. Despite availability of proven-effective interventions for childhood obesity management, effective interventions are underutilized and there remains a substantial gap in the adoption of evidence-based practices in settings that care for low-income children and populations with high burden of social risk factors. This K24 renewal application will support equity-focused implementation research to improve the adoption of effective childhood obesity interventions among clinicians and families and reduce obesity disparities among low-income, racial/ethnic minority children. This application will take advantage of a newly-funded, NHLBI R01 implementation research grant to optimize integration of the Connect for Health pediatric weight management intervention in pediatric primary care settings. With NHLBI funding, we are testing key adaptations and strategies that will support the implementation of Connect for Health across health care systems in Massachusetts that deliver care to low-income children. K24 funding will allow the PI and her mentees to extend and amplify the NHLBI study by examining a new adaptation: use of social- and neighborhood risk-informed obesity care plans to increase the effects of childhood obesity interventions on obesity outcomes. The overall goals of this K24 renewal application are to provide Elsie Taveras MD, MPH with protected time to serve as a mentor to junior clinical investigators in their progress toward becoming independent patient-oriented investigators, and to support new scientific aims that will build upon Dr. Taveras’s established work on childhood obesity, health disparities, and equity-focused implementation science. Dr. Taveras is Professor of Pediatrics and Nutrition at Harvard Medical School and Harvard T.H. Chan School of Public Health, and a pediatric obesity specialist at Massachusetts General Hospital for Children. She leads several large patient-oriented research studies including a NHLBI-funded implementation study that will serve as the basis for her proposed aims. Dr. Taveras has already successfully served as a research mentor to more than 40 MD and PhD candidates and clinicians in training. Her original K24 focused on understanding the contextual roots of childhood obesity disparities and developing interventions to prevent and manage obesity. This K24 renewal award is a natural extension of this work and will shift focus to translational studies and implementation science. The K24 renewal will heighten Dr. Taveras’s research productivity in the area of childhood obesity disparities and help foster the careers of junior childhood obesity scientists through her mentorship. The proposed scientific aims of this K24 application will serve to strengthen Dr. Taveras’s ability to provide mentorship to junior investigators in patient-oriented research, with an emphasis on equity-focused implementation research to improve adoption and effects of childhood obesity interventions.