Documenting and archiving the Safe Passage Study in NICHD Data and Specimen Hub (DASH)

在 NICHD 数据和样本中心 (DASH) 中记录和存档安全通道研究

基本信息

  • 批准号:
    10700943
  • 负责人:
  • 金额:
    $ 7.25万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-08 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT ABSTRACT The Safe Passage Study is the first prospective, observational, large-scale cohort study to investigate the effect of prenatal exposure to alcohol, tobacco and drugs on the risk for Sudden Infant Death Syndrome (SIDS), stillbirth, and Fetal Alcohol Spectrum Disorders (FASD). Participants were recruited from two sites in Cape Town, South Africa, and five sites in the Northern Plains, United States, including two American Indian Reservations between 2007 and 2015. In total, the study enrolled 10,088 women, 11,892 pregnancies, and 12,029 fetuses, followed to 1-year post-delivery. Extensive longitudinal data have been collected during prenatal, delivery/newborn, and postnatal stages. As such, the Safe Passage Study is an important resource for researchers interested in prenatal exposures, child physiological and neurological development, and pathological assessments of SIDS, stillbirth, and FASD. The Safe Passage Study was initiated prior to the NIH data sharing mandate, thus funds were not available for preparation and archiving of a de-identified dataset. To facilitate the use of this valuable resource, we propose to make publicly available the Safe Passage Study datasets via NICHD Data and Specimen Hub (DASH). We will archive and document the existing datasets of Safe Passage Study, which NICHD sponsored along with NIAAA and NIDCD. More specifically, we will 1.) prepare and submit PASS self-reported and medical chart abstraction data, such as maternal and infant characteristics, psychosocial and dietary information, and exposure assessments, to the DASH portal; and 2.) prepare and submit PASS physiology and pathology data, such as autonomic, respiratory, and brain function in the fetus and infant, pathology assessments from autopsy and placental evaluation, and neurologic assessments of the infant to the DASH portal. We will perform data de-identification, create a variable dictionary, prepare datasets and annotation files using the Data Preparation Tool, and submit the Safe Passage Study to NICHD DASH. De-identified data sets produced with support from this grant will be available without restriction to researchers with the exception of data collected on tribal lands, due to sharing restrictions negotiated at the onset of the study. The shared datasets will enable secondary analysis by the scientific community interested in the link between prenatal exposures and child development.
项目摘要 安全通道研究是第一个前瞻性的、观察性的、大规模的队列研究,旨在调查 产前接触酒精、烟草和药物对婴儿猝死综合征(SIDS)风险的影响 死产和胎儿酒精谱系障碍(FASD)。参与者是从开普敦的两个地点招募的, 南非和美国北部平原的五个地点,包括两个美洲印第安人保留地 在2007至2015年间。这项研究总共招募了10,088名女性、11,892名孕妇和12,029名胎儿, 随访至产后1年。在产前收集了大量的纵向数据, 分娩/新生儿和出生后阶段。因此,安全通道研究是以下方面的重要资源 研究人员对产前暴露、儿童生理和神经发育以及 小儿麻痹症、死产和FASD的病理评估。安全通道研究是在NIH之前启动的 数据共享任务,因此没有资金用于编制和归档已查明身份的数据集。至 为了促进这一宝贵资源的使用,我们建议将安全通道研究公之于众 通过NICHD数据和样本中心(DASH)提供的数据集。我们将对现有的数据集进行归档和记录 安全通道研究,由NICHD与NIAAA和NIDCD共同赞助。更具体地说,我们将1。 准备和提交PASS自我报告和病历摘要数据,如母婴 DASH门户的特征、心理社会和饮食信息以及暴露评估;和2. 准备和提交PASS生理和病理数据,如自主神经、呼吸和脑功能 胎儿和婴儿,尸检和胎盘评估的病理学评估,以及神经学评估 把婴儿的身体送到仪表板入口。我们将执行数据识别,创建变量字典,准备 使用数据准备工具的数据集和注记文件,并将安全通道研究报告提交给NICHD 达什。在这笔赠款的支持下产生的未识别的数据集将不受限制地提供给 研究人员除了在部落土地上收集的数据外,由于在 研究的开始。共享的数据集将使感兴趣的科学界能够进行二次分析 产前暴露与儿童发育之间的联系。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Christine W Hockett其他文献

Association of maternal fish consumption and strongω/strong-3 supplement use during pregnancy with child autism-related outcomes: results from a cohort consortium analysis
孕期母亲鱼类摄入量及ω-3补充剂的使用与儿童自闭症相关结局的关联:一项队列联合分析结果
  • DOI:
    10.1016/j.ajcnut.2024.06.013
  • 发表时间:
    2024-09-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Kristen Lyall;Matt Westlake;Rashelle J Musci;Kennedy Gachigi;Emily S Barrett;Theresa M Bastain;Nicole R Bush;Claudia Buss;Carlos A Camargo;Lisa A Croen;Dana Dabelea;Anne L Dunlop;Amy J Elliott;Assiamira Ferrara;Akhgar Ghassabian;James E Gern;Marion E Hare;Irva Hertz-Picciotto;Alison E Hipwell;Christine W Hockett;S Swan
  • 通讯作者:
    S Swan

Christine W Hockett的其他文献

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{{ truncateString('Christine W Hockett', 18)}}的其他基金

Documenting and archiving the Safe Passage Study in NICHD Data and Specimen Hub (DASH)
在 NICHD 数据和样本中心 (DASH) 中记录和存档安全通道研究
  • 批准号:
    10509779
  • 财政年份:
    2022
  • 资助金额:
    $ 7.25万
  • 项目类别:

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