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ACCESS: Accelerating Cervical Cancer Elimination through the integration of Screen-and-treat Services

访问：通过整合筛查和治疗服务加速消除宫颈癌

基本信息

批准号：
10700152
负责人：
GREGORY AARONS
金额：
$ 64万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-07 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10700152
关键词：
Acceleration Acquired Immunodeficiency Syndrome Address Adoption Adult Africa African Aftercare California Cancer Control Cancer Etiology Caring Cervical Cancer Screening Cessation of life Clinical effectiveness Communities Country Data Diagnosis Emergency Situation Epidemic Exploration, Preparation, Implementation, and Sustainment Female General Population Goals HIV HIV Infections Health Health Personnel Health care facility Healthcare Hybrids Implementation readiness Improve Access Individual Infrastructure Intervention Life Expectancy Malignant Neoplasms Malignant neoplasm of cervix uteri Maps Methods Nigeria Outcome Persons Population Prevalence Protocols documentation Randomized Recommendation Reporting Research Resource-limited setting Resources Risk Services System Universities Woman World Health Organization anticancer research antiretroviral therapy arm cancer care comparative effectiveness effectiveness outcome evidence base implementation evaluation implementation outcomes implementation science implementation strategy improved low and middle-income countries meetings mortality programs scale up screening service delivery treatment center treatment program treatment site trial design uptake

项目摘要

Program Summary Nigeria has one of the largest HIV epidemics in the world with 1.8 million people living with HIV infection. With an estimated female population of 102 million and HIV prevalence of 1.6% among adult females, Nigeria has the largest population of women and the 4th largest number of women living with HIV (WLHIV) in Africa. Although access to antiretroviral therapy (ART) among WLHIV in Nigeria has increased over the years, with over 98% of the 960,000 WLHIV on ART, AIDS-related mortality remains high. In 2020, 16,000 WLHIV died from AIDS- related illnesses including cervical cancer. A pilot implementation program in Nigeria demonstrated that leveraging the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) supported HIV programs for the provision of evidence-based cervical cancer screen-and-treat interventions in WLWH is feasible. The pilot program demonstrated, however, that tailored implementation strategies will be needed to address specific multilevel barriers along the cancer control continuum in order to address adoption, reach, and sustainability that are necessary for successful scale-up. However, in many African countries with a high burden of both HIV and cervical cancer, there is a paucity of evidence-based implementation strategies to inform effective integration of HIV and cervical cancer services delivery. Objectives of this proposal are to: 1) Refine strategies to integrate cervical cancer screening, treatment and management within existing comprehensive HIV treatment programs and determine implementation readiness; 2) Determine the comparative effectiveness of a Core set of implementation strategies versus Core+ enhanced implementation strategies; and 3) assess sustainment of the integration of cervical cancer screening, treatment, and management intervention into HIV programs. We have assembled a strong team from University of California San Diego; University of Nigeria, Nsukka and John Hopkins University with expertise in implementation science, HIV care and research, and cancer care and research. Our proposal is responsive to the NCI RFA and consistent with the World Health Organization global plan of elimination of cervical cancer by 2030. If effective, the proposed project will result in a set of feasible, culturally adaptable, and sustainable implementation strategies to integrate evidence-based cervical cancer screening and treatment into HIV programs in order to improve the health and life expectancy of WLHIV.

项目总结