The impact of adverse interpersonal experiences (AIE) on mild cognitive impairment (MCI) and risk for Alzheimer's disease and related dementias (ADRD) in ethnically diverse twins
不良人际经历 (AIE) 对不同种族双胞胎中轻度认知障碍 (MCI) 以及阿尔茨海默病和相关痴呆 (ADRD) 风险的影响
基本信息
- 批准号:10700995
- 负责人:
- 金额:$ 112.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-01 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectAfrican AmericanAgeAged, 80 and overAgingAlzheimer&aposs disease diagnosisAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAmericanBiological ProcessCognitionCognitiveCognitive agingConflict (Psychology)DataDementiaDevelopmentDiseaseEarly identificationEducationElderlyEnvironmentEuropeanFamilyFamily memberFollow-Up StudiesFriendsGeneticGeographyGrantGrowthHealthHeritabilityImpaired cognitionIndividualIndividual DifferencesInterventionLife ExpectancyLightLinkLonelinessLongevityLongitudinal StudiesMeasuresMediatingMethodsMinnesotaModelingOutcomeParticipantPathway interactionsPatternPersonsPopulationPreventionProcessPublic HealthResearchRiskSame-sexScienceSocial EnvironmentSocial isolationTestingTwin Multiple BirthTwin StudiesUnited StatesVariantWorkage relatedaging populationcare costscognitive functioncostdementia riskdesigndiarieseconomic costethnic diversityexpectationexperiencefollow-uphigh riskimprovedmild cognitive impairmentnovelpsychologicpsychosocialsocialsuccess
项目摘要
ABSTRACT
Age-related decline in cognitive health is a pressing public health concern. Variation in late-life
adult cognitive health is associated with adverse interpersonal experiences (AIEs, e.g.,
loneliness), although documenting the full extent of this association requires further study of a
greater diversity of AIEs. Social isolation and lower quality relationships, characterized by
greater conflict, tend to disrupt psychosocial and biological functioning, resulting in increased
risk for Mild Cognitive Impairment (MCI), which, in turn, increases risk for Alzheimer’s Disease
and Related Dementias (ADRD). Conversely, adults who receive more warmth, support, and
responsiveness in their social experiences typically have better cognitive outcomes. This project
takes advantage of an unparalleled opportunity to further this important line of work on the
significance of relationship experiences in later adulthood for MCI by conducting a follow-up of
the Minnesota-Carolina Twin Study of Aging (MCTSA). MCTSA is a longitudinal study targeting
800 ethnically diverse monozygotic and dizygotic same-sex twin pairs. Most twin participants
have already completed assessments of AIEs in the previous project period. In this proposed
continuation period, we will complete novel assessments of MCI. Further, a daily diary study
aimed at connecting AIEs and fluctuations in cognitive functioning on a day-to-day timescale will
allow us to document processes that presage the development of Alzheimer’s Disease and
Related Dementias (ADRD). Our overarching objectives are to investigate the degree to which
diverse AIEs predict subsequent MCI, to take advantage of the twin aspect of our design to
document the environmental basis for AIE-MCI associations, and to understand how these
connections are manifest in the day-to-day flow of interpersonal experiences and cognitive
functioning. Specific aims of this project include: AIM 1: Document longitudinal associations
between a comprehensive array of earlier, specific adverse interpersonal experiences (AIE) and
subsequent mild cognitive impairment (MCI); AIM 2: Model environmental pathways linking
earlier adverse interpersonal experiences (AIE) and subsequent MCI; AIM 3: Complete a twin
daily diary study of within-person dynamics connecting adverse interpersonal experiences and
daily fluctuations in cognitive functioning.
摘要
与年龄相关的认知健康下降是一个紧迫的公共卫生问题。晚年变化
成人认知健康与不良人际关系经历(AIE,例如,
孤独),尽管记录这种关联的全部程度需要进一步研究
经认证的独立实体更加多样化。社会孤立和低质量的关系,其特点是
更大的冲突,往往会破坏心理社会和生物功能,
轻度认知障碍(MCI)的风险,这反过来又增加了阿尔茨海默病的风险
和相关痴呆症(ADRD)。相反,那些得到更多温暖、支持和帮助的成年人,
他们在社会经验中的反应通常有更好的认知结果。这个项目
利用一个无与伦比的机会,进一步这一重要的工作线上,
成年后期的关系经历对MCI的意义,通过对
明尼苏达-卡罗莱纳双胞胎衰老研究(MCTSA)MCTSA是一项纵向研究,
800对不同种族的同卵和异卵同性双胞胎。大多数双胞胎参与者
已经在上一个项目期完成了经认证的独立实体的评估。在此提出的
在延续期内,我们将完成MCI的新评估。此外,每日日记研究
旨在将AIE与日常时间尺度上的认知功能波动联系起来,
使我们能够记录预示阿尔茨海默病发展的过程,
相关痴呆症(ADRD)。我们的首要目标是调查
不同的AIE预测随后的MCI,以利用我们设计的双重方面,
记录AIE-MCI协会的环境基础,并了解这些
联系体现在日常的人际经验和认知流中
功能目标1:记录纵向联系
在早期的一系列全面的,具体的不良人际关系经历(AIE)和
继发性轻度认知功能障碍(MCI); AIM 2:模型环境通路连接
早期不良人际关系经历(AIE)和随后的MCI; AIM 3:完全双胞胎
每日日记研究的人内动态连接不良的人际经验,
认知功能的日常波动
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert F Krueger其他文献
the in HiTOP.
在 HiTOP 中。
- DOI:
- 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
T. Widiger;Bo Bach;M. Chmielewski;L. Clark;C. DeYoung;C. Hopwood;Roman Kotov;Robert F Krueger;Joshua D. Miller;Leslie C. Morey;Stephanie N. Mullins;C. Patrick;A. Pincus;D. Samuel;Martin Sellbom;J. Tackett;David Watson;M. Waugh;Aidan G. C. Wright;Johannes Zimmermann;R. M. Bagby;D. Cicero;Christopher C. Conway;Barbara De Clercq;A. Docherty - 通讯作者:
A. Docherty
Frequently Asked Questions about the Cybernetic Dysfunction Theory
有关控制论功能障碍理论的常见问题
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
C. DeYoung;Robert F Krueger - 通讯作者:
Robert F Krueger
Reconceptualizing mental health in cancer survivorship.
重新概念化癌症生存中的心理健康。
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:18.4
- 作者:
Darren Haywood;Roman Kotov;Robert F Krueger;A. G. Wright;Miriam K. Forbes;Evan Dauer;Frank D. Baughman;S. L. Rossell;Nicolas H. Hart - 通讯作者:
Nicolas H. Hart
New Dimensions in the Quantitative Classification of Mental Illness Participants: Outpatients (n = 2900) Seeking Psychi- Atric Treatment
精神疾病定量分类的新维度参与者:寻求精神治疗的门诊患者 (n = 2900)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
Roman Kotov;C. Ruggero;Robert F Krueger;David Watson;Qilong Yuan;Mark Zimmerman;New York.;Drs Kotov;Yuan - 通讯作者:
Yuan
Robert F Krueger的其他文献
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{{ truncateString('Robert F Krueger', 18)}}的其他基金
Antecedents of Adult Physical Health and Cognitive Risks for Alzheimer's Disease and Related Dementias (ADRD) in Adolescent Family Experiences: A Prospective, Longitudinal Adoption Study
青少年家庭经历中成人身体健康和阿尔茨海默氏病及相关痴呆症 (ADRD) 认知风险的前因:一项前瞻性、纵向收养研究
- 批准号:
10464655 - 财政年份:2022
- 资助金额:
$ 112.59万 - 项目类别:
Antecedents of Adult Physical Health and Cognitive Risks for Alzheimer's Disease and Related Dementias (ADRD) in Adolescent Family Experiences: A Prospective, Longitudinal Adoption Study
青少年家庭经历中成人身体健康和阿尔茨海默氏病及相关痴呆症 (ADRD) 认知风险的前因:一项前瞻性、纵向收养研究
- 批准号:
10630366 - 财政年份:2022
- 资助金额:
$ 112.59万 - 项目类别:
The impact of adverse interpersonal experiences (AIE) on mild cognitive impairment (MCI) and risk for Alzheimer's disease and related dementias (ADRD) in ethnically diverse twins
不良人际经历 (AIE) 对不同种族双胞胎中轻度认知障碍 (MCI) 以及阿尔茨海默病和相关痴呆 (ADRD) 风险的影响
- 批准号:
10538923 - 财政年份:2016
- 资助金额:
$ 112.59万 - 项目类别:
The contributions of personality and social relationships to late-life health: A twin study approach
人格和社会关系对晚年健康的贡献:双胞胎研究方法
- 批准号:
9151825 - 财政年份:2016
- 资助金额:
$ 112.59万 - 项目类别:
Neurobehavioral Aspects of Personality & Psychopathology
人格的神经行为方面
- 批准号:
7084403 - 财政年份:1988
- 资助金额:
$ 112.59万 - 项目类别:
Neurobehavioral Aspects of Personality & Psychopathology
人格的神经行为方面
- 批准号:
6876594 - 财政年份:1988
- 资助金额:
$ 112.59万 - 项目类别:
Neurobehavioral Aspects of Personality & Psychopathology
人格的神经行为方面
- 批准号:
7232535 - 财政年份:1988
- 资助金额:
$ 112.59万 - 项目类别:
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