The impact of adverse interpersonal experiences (AIE) on mild cognitive impairment (MCI) and risk for Alzheimer's disease and related dementias (ADRD) in ethnically diverse twins

摘要 与年龄相关的认知健康下降是一个紧迫的公共卫生问题。晚年生活的变化 成人认知健康与不良的人际体验有关(例如， 孤独)，尽管记录这种联系的全面程度需要进一步研究 更多样化的AIE。社会孤立和较低质量的关系，其特征是 更大的冲突，往往会扰乱心理社会和生物功能，导致 轻度认知障碍(MCI)的风险，这反过来又增加了阿尔茨海默病的风险 和相关痴呆症(ADRD)。相反，成年人得到更多的温暖、支持和 他们的社会经历中的响应性通常会有更好的认知结果。这个项目 利用一个无与伦比的机会来推动这项重要的工作 成年后恋爱经历对MCI的意义--通过对 明尼苏达州-卡罗莱纳州双胞胎老龄化研究(MCTSA)。MCTSA是一项纵向研究，目标是 800对种族多样的同卵和异卵同性双胞胎。大多数双胞胎参与者 在上一个项目期内已经完成了对AIE的评估。在本建议中 在继续期间，我们将完成对MCI的全新评估。此外，每天的日记研究 旨在将AIE和认知功能在日常时间尺度上的波动联系起来 使我们能够记录预示阿尔茨海默病发展的过程和 相关痴呆症(ADRD)。我们的首要目标是调查 不同的AIE预测后续的MCI，以利用我们设计的两个方面来 记录AIE-MCI协会的环境基础，并了解这些 联系体现在人际体验和认知的日常流动中。 功能正常。该项目的具体目标包括：目标1：文件纵向联系 在一系列较早的、特定的不良人际关系体验(AIE)和 随后的轻度认知障碍(MCI)；目标2：模拟环境通路联系 早期不良人际关系经历(AIE)和随后的MCI；目标3：完成双胞胎 连接不良人际体验和人际关系的人内动态的日常日记研究 认知功能的日常波动。

ABSTRACT Age-related decline in cognitive health is a pressing public health concern. Variation in late-life adult cognitive health is associated with adverse interpersonal experiences (AIEs, e.g., loneliness), although documenting the full extent of this association requires further study of a greater diversity of AIEs. Social isolation and lower quality relationships, characterized by greater conflict, tend to disrupt psychosocial and biological functioning, resulting in increased risk for Mild Cognitive Impairment (MCI), which, in turn, increases risk for Alzheimer’s Disease and Related Dementias (ADRD). Conversely, adults who receive more warmth, support, and responsiveness in their social experiences typically have better cognitive outcomes. This project takes advantage of an unparalleled opportunity to further this important line of work on the significance of relationship experiences in later adulthood for MCI by conducting a follow-up of the Minnesota-Carolina Twin Study of Aging (MCTSA). MCTSA is a longitudinal study targeting 800 ethnically diverse monozygotic and dizygotic same-sex twin pairs. Most twin participants have already completed assessments of AIEs in the previous project period. In this proposed continuation period, we will complete novel assessments of MCI. Further, a daily diary study aimed at connecting AIEs and fluctuations in cognitive functioning on a day-to-day timescale will allow us to document processes that presage the development of Alzheimer’s Disease and Related Dementias (ADRD). Our overarching objectives are to investigate the degree to which diverse AIEs predict subsequent MCI, to take advantage of the twin aspect of our design to document the environmental basis for AIE-MCI associations, and to understand how these connections are manifest in the day-to-day flow of interpersonal experiences and cognitive functioning. Specific aims of this project include: AIM 1: Document longitudinal associations between a comprehensive array of earlier, specific adverse interpersonal experiences (AIE) and subsequent mild cognitive impairment (MCI); AIM 2: Model environmental pathways linking earlier adverse interpersonal experiences (AIE) and subsequent MCI; AIM 3: Complete a twin daily diary study of within-person dynamics connecting adverse interpersonal experiences and daily fluctuations in cognitive functioning.