The impact of adverse interpersonal experiences (AIE) on mild cognitive impairment (MCI) and risk for Alzheimer's disease and related dementias (ADRD) in ethnically diverse twins

摘要 与认知健康相关的认知健康下降是一个紧迫的公共卫生问题。晚年变化 成人认知健康与不良人际关系经历（AIE，例如， 孤独），尽管记录这种关联的全部程度需要进一步研究 经认证的独立实体更加多样化。社会孤立和低质量的关系，其特点是 更大的冲突，往往会破坏心理社会和生物功能， 轻度认知障碍（MCI）的风险，这反过来又增加了阿尔茨海默病的风险 和相关痴呆症（ADRD）。相反，那些得到更多温暖、支持和帮助的成年人， 他们在社会经验中的反应通常有更好的认知结果。这个项目 利用一个无与伦比的机会，进一步这一重要的工作线上， 成年后期的关系经历对MCI的意义，通过对 明尼苏达-卡罗莱纳双胞胎衰老研究（MCTSA）MCTSA是一项纵向研究， 800对不同种族的同卵和异卵同性双胞胎。大多数双胞胎参与者 已经在上一个项目期完成了经认证的独立实体的评估。在此提出的 在延续期内，我们将完成MCI的新评估。此外，每日日记研究 旨在将AIE与日常时间尺度上的认知功能波动联系起来， 使我们能够记录预示阿尔茨海默病发展的过程， 相关性痴呆（ADRD）。我们的首要目标是调查 不同的AIE预测随后的MCI，以利用我们设计的双重方面， 记录AIE-MCI协会的环境基础，并了解这些 联系体现在日常的人际经验和认知流中 功能目标1：记录纵向联系 在早期的一系列全面的，具体的不良人际关系经历（AIE）和 继发性轻度认知功能障碍（MCI）; AIM 2：模型环境通路连接 早期不良人际关系经历（AIE）和随后的MCI; AIM 3：完全双胞胎 每日日记研究的人内动态连接不良的人际经验， 认知功能的日常波动

ABSTRACT Age-related decline in cognitive health is a pressing public health concern. Variation in late-life adult cognitive health is associated with adverse interpersonal experiences (AIEs, e.g., loneliness), although documenting the full extent of this association requires further study of a greater diversity of AIEs. Social isolation and lower quality relationships, characterized by greater conflict, tend to disrupt psychosocial and biological functioning, resulting in increased risk for Mild Cognitive Impairment (MCI), which, in turn, increases risk for Alzheimer’s Disease and Related Dementias (ADRD). Conversely, adults who receive more warmth, support, and responsiveness in their social experiences typically have better cognitive outcomes. This project takes advantage of an unparalleled opportunity to further this important line of work on the significance of relationship experiences in later adulthood for MCI by conducting a follow-up of the Minnesota-Carolina Twin Study of Aging (MCTSA). MCTSA is a longitudinal study targeting 800 ethnically diverse monozygotic and dizygotic same-sex twin pairs. Most twin participants have already completed assessments of AIEs in the previous project period. In this proposed continuation period, we will complete novel assessments of MCI. Further, a daily diary study aimed at connecting AIEs and fluctuations in cognitive functioning on a day-to-day timescale will allow us to document processes that presage the development of Alzheimer’s Disease and Related Dementias (ADRD). Our overarching objectives are to investigate the degree to which diverse AIEs predict subsequent MCI, to take advantage of the twin aspect of our design to document the environmental basis for AIE-MCI associations, and to understand how these connections are manifest in the day-to-day flow of interpersonal experiences and cognitive functioning. Specific aims of this project include: AIM 1: Document longitudinal associations between a comprehensive array of earlier, specific adverse interpersonal experiences (AIE) and subsequent mild cognitive impairment (MCI); AIM 2: Model environmental pathways linking earlier adverse interpersonal experiences (AIE) and subsequent MCI; AIM 3: Complete a twin daily diary study of within-person dynamics connecting adverse interpersonal experiences and daily fluctuations in cognitive functioning.