Center for Cell-based Therapy - Cures

细胞治疗中心的使命是促进癌症患者细胞免疫疗法的发现和发展。这项工作的两个重要目标是：(1)开发基于细胞的免疫治疗成功靶向实体肿瘤的方法；(2)促进具有强大临床潜力的基于细胞的协作治疗项目。该项目目前正在开发的四个领域是：(1)与Mitchell Ho、Rosandra Kaplan和Carol Thiele合作，开发靶向GPC2的CAR-T细胞作为神经母细胞瘤的治疗方法；(2)与mitchell Ho和Ira Pastan合作，开发靶向间皮素的CAR-T细胞，用于间皮瘤和肺腺癌的治疗；(3)与Mitchell Ho合作开发CAR-T细胞，将感兴趣的基因传递到肿瘤微环境中；(4)与Rosandra Kaplan合作，鉴定髓细胞免疫抑制和肿瘤杀伤的关键基因。这可能有助于改进基于细胞的治疗策略。

The mission of the Center for Cell-based Therapy is to facilitate the discovery and development of cellular immunotherapies for patients with cancer. Two important objectives of this work are: (1) developing approaches to successfully target solid tumors with cell-based immunotherapy, and (2) facilitating collaborative cell-based therapy projects with strong clinical potential. Four areas currently in development for this project are: (1) developing CAR-T Cells targeting GPC2 as a treatment for Neuroblastoma in collaboration with Mitchell Ho, Rosandra Kaplan, and Carol Thiele; (2) creating CAR-T Cells targeting mesothelin as a therapy for mesothelioma and lung adenocarcinoma in collaboration with Mitchel Ho and Ira Pastan; (3) developing CAR-T cells to deliver genes of interest into the tumor micro-environment in collaboration with Mitchell Ho; and (4) identification of key genes driving immune suppression and tumor killing in myeloid cells in collaboration with Rosandra Kaplan. This could potentially facilitate the improvement of cell-based therapy strategies.