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Analysis of cancer-related immune suppressor mechanisms in mice

Analysis of cancer-related immune suppressor mechanisms in mice
小鼠癌症相关免疫抑制机制分析
批准号：
10262296
负责人：
Tim Greten
金额：
$174.7万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10262296
关键词：
AffectAnimal ModelBile AcidsCell physiologyCellsCirrhosisFatty LiverImmune responseImmunologic SurveillanceImmunosuppressive AgentsImmunotherapyImpairmentInfectionInflammationLiverLiver diseasesMalignant NeoplasmsMusPortal vein structureTestingTumor EscapeTumor Immunityabsorptiongut microbiomeimmunoregulationmicrobiometumortumor growth

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英文摘要
It has been shown that tumors have developed numerous ways to escape tumor specific immune responses. These mechanisms will ultimately not only enhance tumor growth, but also impair the effect of immune based therapies in cancer. In the past year we were able to complete a study showing how the gut microbiome controls bile acids in the gut, which in turn after absorption into the portal vein control accumulation of NKT cells in the liver. These cells control tumor growth in several animal models and we are currently testing the regulation of immune function of these cells. In addition we have extended our studies on fatty liver disease and study how fatty liver disease affects anti-tumor immunity
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