课题基金 / 基金详情

Analysis of tumor cell death on antigen-specific immune responses

Analysis of tumor cell death on antigen-specific immune responses
肿瘤细胞死亡对抗原特异性免疫反应的分析
批准号：
8175347
负责人：
Tim Greten
金额：
$17.22万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8175347
关键词：
AntigensApoptoticCD8B1 geneCell DeathCellsDataGenerationsImmune responseIn VitroInduction of ApoptosisMolecularNecrosisPatternSystemT-Cell ActivationT-Lymphocytebaseimmunogenicin vivoneoplastic cellresponsetumor

项目摘要

项目成果

Tim Greten的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
The way in which tumor cells die is proposed to have a substantial impact on the generation of adaptive immune responses. In our previous studies we have been able to demonstrate that induction of apoptosis versus necrosis in subcutaneously growing tumors has prfoundly different effects on tumor specific CD8+ T cells. While apoptotic tumor cell death promote anti-tumor immune responses necrotic tumor cell death impair these responses. Based on these in vivo findings we have been able to establish an in vitro system, which allows to dissect the immunological mechanisms responsible for these observations in more detail.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Center for Cell-based Therapy - Cures
Immune suppressor mechanism in a murine model of hepatitis and liver cancer
Immune suppressor mechanisms in patients with GI cancer
Clinical protocols for the treatment of gastrointestinal cancer
海外基金