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Immune suppressor mechanisms in patients with GI cancer

Immune suppressor mechanisms in patients with GI cancer
胃肠道癌症患者的免疫抑制机制
批准号：
10014628
负责人：
Tim Greten
金额：
$10.58万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10014628
关键词：
CellsCellular biologyCorrelative StudyFlow CytometryGene Expression ProfilingImmuneImmunotherapyMalignant NeoplasmsMalignant neoplasm of gastrointestinal tractManuscriptsMyeloid-derived suppressor cellsPatientsPeripheral Blood Mononuclear CellPublishingSamplingT-LymphocyteTumor ImmunityWorkanti-CTLA4basenovel strategiestumor

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英文摘要
One of the major problems in immune therapy is that we do not understand why some treatments work and others fail in patients. We use samples from patients treated with anti-CTLA4 plus locoregional therapy to better understand how immune based approaches work in HCC. We are studying tumor samples from patients on our studies using gene expression analysis and perform flow cytometry studies on PBMC. These studies are ongoing. So far, we have been able to demonstrate that patients with tumor infiltrating T cells are more likely to respond to anti-CTLA4 plus locoregional therapy. We have recently published a manuscript describing correlative studies for NCI-C0120.
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