Reuse in RI: A State-based Approach to Complex Exposures

描述(由申请人提供) 这一超级基金基础研究和培训计划-在RL中重用：基于状态的复杂暴露方法-体现了三个相互关联的主题组成部分：1)RI中的土地重新利用，2)基于状态的方法，以及3)复杂暴露。国际扶轮面积小，人口稠密，而且背负着漫长的工业活动历史。在这种背景下，学者、政府领导人和社区成员以有效的方式共同努力，开发一种独特的、面向国家的、跨学科的土地恢复和再利用方法，障碍相对较少。这种学术-政府-社区的合作努力将解决与危险废物场地固有的复杂混合物和共同暴露相关的基础和翻译研究问题、管理决策和沟通障碍。 研究工作涉及与共暴露相关的疾病机制和潜在生物标记物的理论和实践方面(4个生物医学项目)，以及复杂混合物的识别、表征、分离和补救(3个工程项目)。这些项目得到了分析核心、分子病理学核心和培训核心的支持。研究翻译核心与社区外展核心合作，将促进参与的学者、政府领导人和社区成员之间的知识和信息流动，形成真正的大学-州-社区伙伴关系。管理核心提供促进沟通、关键自我评估和资源管理的基础设施。 该计划为RICER提供了一个反应灵敏的技术卓越中心，该中心采用以研究为导向的方法，通过关注以下具体目标，解决在考虑危险废物场地再利用时出现的复杂的科学、工程和社会问题：1)确定和解决与再利用场地复杂混合物的化学和物理相互作用有关的关键科学和技术问题；2)了解涉及共同暴露的毒物引起疾病的基本机制；3)有效地传达潜在的健康危害，并指导制定适当补救和再利用受污染场地的计划；以及4)提供关于复杂混合物和共同暴露的健康后果的专业知识。

DESCRIPTION (provided by applicant) This Superfund Basic Research and Training Program-REUSE IN Rl: A STATE-BASED APPROACH TO COMPLEX EXPOSURES-embodies three inter-related thematic components: 1) land reuse in RI, 2) a state-based approach, and 3) complex exposures. RI is small, densely populated, and burdened by a long history of industrial activity. In this setting, there are relatively few barriers to academics, government leaders, and community members working together in an effective fashion to develop a unique state-oriented, interdisciplinary approach to land rehabilitation and reuse. This cooperative academic-government-community effort will address basic and translational research issues, management decisions, and communication barriers associated with the complex mixtures and co-exposures inherent to hazardous waste sites. The research effort addresses theoretical and practical aspects of disease mechanisms and potential biomarkers associated with co-exposures (4 biomedical projects) and the identification, characterization, separation, and remediation of complex mixtures (3 engineering projects). These projects are supported by an Analytical Core, a Molecular Pathology Core, and a Training Core. The Research Translation Core, in cooperation with a Community Outreach Core, will facilitate the flow of knowledge and information among the participating academics, government leaders, and community members in a true university-state-community partnership. The Administrative Core provides the infrastructure to promote communication, critical self-evaluation, and resource management. This program provides RIers with a responsive center of technical excellence that takes a research-oriented approach to resolving the complex scientific, engineering, and societal issues that arise when considering the reuse of hazardous waste sites, by focusing on the following specific objectives: 1) identify and resolve key scientific and technological issues related to chemical and physical interactions of complex mixtures at reuse sites, 2) understand basic mechanisms of toxicant-induced disease involving co-exposures, 3) effectively communicate the potential health hazards and guide the development of plans for the appropriate remediation and reuse of contaminated sites, and 4) provide expertise about complex mixtures and the health consequences of co-exposures.