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Four-dimensional multi-modality microimaging-microdevice system for high throughput drug screening in vivo

用于高通量体内药物筛选的四维多模态显微成像-微器件系统

基本信息

批准号：
10707307
负责人：
Guigen Liu
金额：
$ 17.28万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-30 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10707307
关键词：
3-Dimensional 4D Imaging Adoption Award Biomedical Research Biopsy Calibration Catheters Cell Death Cells Clinical Clinical Oncology Color Custom Dependence Development Development Plans Diffusion Doctor of Philosophy Dose Drug Delivery Systems Drug Evaluation Drug Exposure Engineering Environment Evaluation Event Excision Fiber Optics Fluorescence Four-dimensional Future Generations Goals Healthcare Histologic Hospitals Image Imaging Device Imaging technology Immune Implant In Situ In Vitro Intervention Investigation Label Laboratories Laboratory Research Lasers Learning Length Location MC38 Manuscripts Massachusetts Mechanics Mentors Methods Microscopy Needles Optics Organ Paper Patients Pharmaceutical Preparations Procedures Protocols documentation Publications Publishing Quantitative Evaluations Radiology Specialty Raman Spectrum Analysis Reporting Research Research Activity Research Personnel Resolution Resources Signal Transduction Silicon Site Skin Tissue Speed Subcutaneous Tissue System Systems Development Technology Testing Three-Dimensional Imaging Time Tissues Training Training Activity Translating Tumor Tissue Visualization Woman brain tissue career career development clinical application design drug development drug efficacy drug testing experience experimental study flexibility fluorescence imaging high throughput technology high-throughput drug screening imaging probe imaging system immune cell infiltrate in vivo in vivo evaluation in vivo imaging innovation instructor interest leadership development lens medical schools microdevice minimally invasive multimodality optical fiber optical imaging post-doctoral training programs quantitative imaging response sensor technology skill acquisition skills standard of care success tool translational oncology tumor two-dimensional two-photon

项目摘要

Project Summary Guigen Liu, Ph.D., is a mechanical and optical engineer whose overarching career goal is to develop and translate optical fiber based biomedical optical imaging and sensing technologies. The research, entitled “Four- dimensional multi-modality microimaging-microdevice system for high throughput drug screening in vivo”, combines the advanced optical microimaging system with an emerging microdevice, which has the huge potential impact on drug development, individualized health care, and fundamental biomedical research. Candidate: Dr. Liu is an Instructor at the Radiology Department of Brigham and Women’s Hospital, Harvard Medical School. During his previous postdoctoral training, he and colleagues pioneered a silicon-tipped fiber- optic sensing platform featuring high speed and high resolution, which earned the 2015 Alan Berman Research Publication Award from the U.S. Naval Research Laboratory. While Dr. Liu has shown a successful track of record in engineering, his training in biomedical research is limited. Through the career development plans: 1) Gain more experience in two-photon fluorescence and Raman microimaging; 2) Learn to design and implement the microimaging-microdevice system; 3) Establish in vivo drug delivery and tissue response testing skills; and 4) Enhance leadership and career development skills, Dr. Liu will launch his independent career in the new field. Mentors/Environment: Dr. Liu has assembled a strong team of mentors to guide him through the proposed training and research activities. The proposed career development plan includes the rich resources available through Brigham & Women’s Hospital and Harvard Medical School, the Tearney Laboratory at the Wellman Center for Photomedicine, and the Laser Biomedical Research Center at Massachusetts Institute of Technology. Research: The research seeks to build an in situ multi-modality optical histological laboratory for the biomedical microdevice, through four specific research aims: 1) To implement quantitative 4D multi-color two-photon fluorescence microimaging; 2) To test drug efficacy in vivo using the 4D two-photon fluorescence MI-MD system; 3) To develop label-free MI-MD system using Raman microscopy; and 4) To investigate microimaging through long and flexible GRIN probes. Completion of these aims will push the microdevice a big step toward potential clinical adoptions in the future. Summary: Innovation of the proposed research is the integration of 3D microimaging and microdevice for 4D testing of drug efficacy and tissue response in vivo, which will meet the pressing needs of high throughput drug screening. The candidate has identified a group of experts who provide complementary training and mentoring on all the aspects for him to complete the proposed research and develop an independent research career.

项目总结