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Four-dimensional multi-modality microimaging-microdevice system for high throughput drug screening in vivo

用于高通量体内药物筛选的四维多模态显微成像-微器件系统

基本信息

批准号：
10590171
负责人：
Guigen Liu
金额：
$ 17.29万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-30 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10590171
关键词：
3-Dimensional 4D Imaging Adoption Award Biomedical Research Biopsy Calibration Catheters Cell Death Cells Clinical Clinical Oncology Color Custom Dependence Development Development Plans Diffusion Doctor of Philosophy Dose Drug Delivery Systems Drug Evaluation Drug Exposure Engineering Environment Evaluation Event Excision Fiber Optics Fluorescence Four-dimensional Future Generations Goals Healthcare Histologic Hospitals Image Imaging technology Immune Implant In Situ In Vitro Infiltration Institutes Intervention Investigation Label Laboratories Laboratory Research Lasers Learning Length Location MC38 Manuscripts Massachusetts Mechanics Mentors Methods Microscopy Needles Optics Organ Patients Pharmaceutical Preparations Procedures Protocols documentation Publications Publishing Quantitative Evaluations Radiology Specialty Raman Spectrum Analysis Reporting Research Research Activity Research Personnel Resolution Resources Signal Transduction Silicon Site Skin Tissue Speed Subcutaneous Tissue System Systems Development Technology Testing Three-Dimensional Imaging Time Tissues Training Training Activity Translating Tumor Tissue Visualization Woman base brain tissue career career development clinical application design drug development drug efficacy drug testing experience experimental study flexibility fluorescence imaging high throughput technology high-throughput drug screening imaging probe imaging system in vivo in vivo evaluation in vivo imaging innovation instructor interest leadership development lens medical schools microdevice minimally invasive multimodality optical fiber optical imaging post-doctoral training programs quantitative imaging response sensor technology skill acquisition skills standard of care success tool translational oncology tumor two-dimensional two-photon

项目摘要

Project Summary Guigen Liu, Ph.D., is a mechanical and optical engineer whose overarching career goal is to develop and translate optical fiber based biomedical optical imaging and sensing technologies. The research, entitled “Four- dimensional multi-modality microimaging-microdevice system for high throughput drug screening in vivo”, combines the advanced optical microimaging system with an emerging microdevice, which has the huge potential impact on drug development, individualized health care, and fundamental biomedical research. Candidate: Dr. Liu is an Instructor at the Radiology Department of Brigham and Women’s Hospital, Harvard Medical School. During his previous postdoctoral training, he and colleagues pioneered a silicon-tipped fiber- optic sensing platform featuring high speed and high resolution, which earned the 2015 Alan Berman Research Publication Award from the U.S. Naval Research Laboratory. While Dr. Liu has shown a successful track of record in engineering, his training in biomedical research is limited. Through the career development plans: 1) Gain more experience in two-photon fluorescence and Raman microimaging; 2) Learn to design and implement the microimaging-microdevice system; 3) Establish in vivo drug delivery and tissue response testing skills; and 4) Enhance leadership and career development skills, Dr. Liu will launch his independent career in the new field. Mentors/Environment: Dr. Liu has assembled a strong team of mentors to guide him through the proposed training and research activities. The proposed career development plan includes the rich resources available through Brigham & Women’s Hospital and Harvard Medical School, the Tearney Laboratory at the Wellman Center for Photomedicine, and the Laser Biomedical Research Center at Massachusetts Institute of Technology. Research: The research seeks to build an in situ multi-modality optical histological laboratory for the biomedical microdevice, through four specific research aims: 1) To implement quantitative 4D multi-color two-photon fluorescence microimaging; 2) To test drug efficacy in vivo using the 4D two-photon fluorescence MI-MD system; 3) To develop label-free MI-MD system using Raman microscopy; and 4) To investigate microimaging through long and flexible GRIN probes. Completion of these aims will push the microdevice a big step toward potential clinical adoptions in the future. Summary: Innovation of the proposed research is the integration of 3D microimaging and microdevice for 4D testing of drug efficacy and tissue response in vivo, which will meet the pressing needs of high throughput drug screening. The candidate has identified a group of experts who provide complementary training and mentoring on all the aspects for him to complete the proposed research and develop an independent research career.

项目概要 Guigen Liu 博士是一名机械和光学工程师，其首要职业目标是开发和转化基于光纤的生物医学光学成像和传感技术。该研究题为“四用于高通量体内药物筛选的多维多模态微成像-微器件系统”，将先进的光学显微成像系统与新兴的微型器件相结合，具有巨大的对药物开发、个性化医疗保健和基础生物医学研究的潜在影响。候选人：刘博士是哈佛大学布莱根妇女医院放射科讲师医学院。在之前的博士后培训期间，他和同事首创了硅尖光纤具有高速、高分辨率的光学传感平台，荣获2015年Alan Berman Research奖美国海军研究实验室出版奖。虽然刘博士已经展示了成功的轨迹他在工程方面的记录有限，但他在生物医学研究方面的训练却很有限。通过职业发展计划：1）在双光子荧光和拉曼显微成像方面获得更多经验； 2）学习设计和实现显微成像-显微器件系统； 3）建立体内药物递送和组织反应测试技能；和 4）增强领导力和职业发展技能，刘博士将在新的领域开启他的独立职业生涯。导师/环境：刘博士组建了一支强大的导师团队来指导他完成拟议的项目培训和研究活动。拟议的职业发展计划包括丰富的可用资源通过布莱根妇女医院和哈佛医学院、威尔曼的蒂尔尼实验室麻省理工学院光医学中心和激光生物医学研究中心。研究：该研究旨在为生物医学建立原位多模态光学组织学实验室微器件，通过四个具体研究目标：1）实现定量4D多色双光子荧光显微成像； 2）利用4D双光子荧光MI-MD系统测试体内药效； 3）开发使用拉曼显微镜的无标记MI-MD系统； 4) 通过以下方式研究显微成像长而灵活的 GRIN 探针。这些目标的完成将推动微型设备向潜力迈进一大步未来临床采用。摘要：本研究的创新之处在于 3D 微成像和 4D 微器件的集成体内药效和组织反应测试，满足高通量药物的迫切需求筛选。候选人已经确定了一组提供补充培训和指导的专家在所有方面帮助他完成拟议的研究并发展独立的研究生涯。