Training Program in Signal Transduction and Cancer

描述(由申请者提供)：本申请是对西北大学罗伯特·H·卢里综合癌症中心信号转导与癌症培训项目(T32 CA070085)的持续资助申请，该中心是美国国家癌症研究所资助的综合性癌症中心。信号转导和癌症培训计划于1997年获得了NCI的资助，并于2002年获得了更新资金。该培训计划汇集了对受体、生长因子和信号转导途径感兴趣的教职员工和博士后研究员，并为信号转导和癌症领域的博士后研究员提供培训。这些教授都是由美国国立卫生研究院资助的研究人员，他们属于癌症中心的所有五个基础科学项目：病毒致癌；肿瘤侵袭、转移和血管生成；癌症中的激素和信号转导；癌症基因和分子调控以及癌细胞生物学。项目凝聚力是通过有组织的会议、期刊俱乐部、研讨会和专题讨论会来实现的。这些活动为分享最新科学成果和促进智力合作和互动提供了一个有组织的论坛。在过去九年中，该培训方案成功地培训了24名博士后研究员，其中包括3名少数民族学员。除实验室研究外，受训者还必须参加与该计划相关的教育活动(实验室会议、期刊俱乐部、研讨会、座谈会)。所有受训人员都要参加伦理座谈会。我们目前正在预约10年级，并在《科学》杂志上刊登了广告，以吸引最好的候选人加入该计划。基于我们预期我们将保持相同的高素质申请者候选人人才库，我们请求在本申请的五年期间继续为每年四个博士后职位提供资金。这将使我们能够继续在Robert H.Lurie综合癌症中心进行信号转导和癌症方面的博士后重点培训。鉴于癌症是美国第二大致死原因，我们的信号转导和癌症培训计划与这一重要的公共卫生问题直接相关。

DESCRIPTION (provided by applicant): This application is a request for continued funding of the Training Program in Signal Transduction and Cancer (T32 CA070085) at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, an NCI-funded comprehensive cancer center. The Training Program in Signal Transduction and Cancer received funding from the NCI in 1997 and renewal funding in 2002. The Training Program brings together faculty and postdoctoral fellows with a focused interest in receptors, growth factors and signal transduction pathways and trains postdoctoral fellows for a career in signal transduction and cancer. The preceptors are established NIH funded investigators and they belong to all five basic science programs of the Cancer Center: Viral Oncogenesis; Tumor Invasion, Metastasis and Angiogenesis; Hormones and Signal Transduction in Cancer, Cancer Genes and Molecular Regulation and Cancer Cell Biology. Program cohesion is accomplished through organized meetings, journal clubs and seminars and symposia. These activities provide a structured forum for sharing the latest scientific results and promote intellectual collaborations and interactions. Over the last nine years the Training Program has successfully trained 24 postdoctoral fellows, including three minority trainees. Trainees are required to attend the educational activities (laboratory meetings, journal club, seminars, symposia) associated with the Program in addition to their laboratory research. All trainees enroll in the Ethics Colloquium. We are currently making appointments for Year 10 and advertisements have been placed in the journal Science to attract the best candidates to join the Program. Based on our expectation that we will maintain the same candidate pool of highly qualified applicants we request continued funding for the four postdoctoral positions per year for a period of five years in the present application. This will enable us to continue focused postdoctoral training in Signal Transduction and Cancer at the Robert H. Lurie Comprehensive Cancer Center. In view of the fact that cancer is the second leading cause of death in the U.S., our Training Program in Signal Transduction and Cancer has direct relevance to this important public health issue.