Cancer Prevention and Control Research Program

项目摘要/摘要 马基癌症中心(MCC)癌症预防和控制(CP)研究计划培养高 以减少癌症为首要目标的以人口为基础和社区参与的影响研究 肯塔基州的差距。CP研究横跨人口科学转化管道 了解危险因素和干预目标，开发和测试新的干预措施，研究 传播和实施循证干预措施付诸实践的过程。有影响力的 科学贡献包括人类乳头瘤病毒与患者存活率的遗传关联。 口咽癌，对新型无烟烟草产品的及时监管和政策研究，试验 创新干预措施以减少致癌环境暴露，试验干预措施以促进 农村癌症幸存者的生活质量结果，以及预防肝炎的社区实施试验 C传播和在整个社区实施癌症预防和筛查指南 肯塔基州和阿巴拉契亚。CP的影响还延伸到肯塔基州和全国的公共卫生政策，以及 在提高与戒烟和肺癌筛查相关的护理标准方面。CP计划 结合这些优势来解决三个目标：促进对风险因素的理解和干预 癌症预防和控制目标(目标1)；制定和测试各种干预措施的效果 癌症控制连续体(目标2)；研究循证医学的传播和实施 干预措施(目标3)。CP计划已经通过大量战略投资进行了转变，这些投资包括 导致了新的领导层，并通过注入多个招聘人员扩大了 项目研究，结合长期项目成员的持续成功。该计划的 同行评审的资金增加了50%，NCI的资金到目前为止大幅增长了567% 占同行审查资金的33%，而2017年为7%。该计划的成熟在以下方面是显而易见的 临床试验收益增加24%，NCI P01和UH3多项研究人员获奖， 机构赠款和唯一的NCI T32侧重于农村癌症差异。CP调查人员高度重视 参与并响应MCC集水区居民的需求，并参与 方案研究，与社区合作，解决MCC的集水区研究优先事项 外展和参与。因此，CP计划对于实现MCC的总体任务是不可或缺的 癌症负担，重点是肯塔基州及其最脆弱的人群，通过研究，预防， 治疗、教育和社区参与。

PROJECT SUMMARY/ABSTRACT Markey Cancer Center’s (MCC) Cancer Prevention and Control (CP) Research Program fosters high- impact, population-based and community-engaged research with the overarching goal of reducing cancer disparities in Kentucky. CP research spans the population science translation pipeline from advancing understanding of risk factors and intervention targets, to developing and testing new interventions, to studying the process of dissemination and implementation of evidence-based interventions into practice. Impactful scientific contributions include genetic associations of human papillomavirus and patient survival in oropharyngeal cancer, timely regulatory and policy research on novel smokeless tobacco products, trials of innovative interventions to reduce carcinogenic environmental exposures, trials of interventions to promote quality of life outcomes among rural cancer survivors, and community implementation trials to prevent hepatitis C transmission and implement cancer prevention and screening guidelines in communities throughout Kentucky and Appalachia. CP impact also extends to public health policy within Kentucky and nationally, and in advancing standards of care related to tobacco cessation and lung cancer screening. The CP Program combines these strengths to address three Aims: Advance the understanding of risk factors and intervention targets for cancer prevention and control (Aim 1); Develop and test the efficacy of interventions across the cancer control continuum (Aim 2); Study the dissemination and implementation of evidence-based interventions (Aim 3). The CP Program has been transformed by substantial strategic investments that have led to new leadership and by the infusion of multiple recruitments that have expanded the breadth and depth of program research, combined with the continued success of long-standing program members. The program’s peer-reviewed funding has increased by 50%, and NCI funding has grown dramatically by 567% to now comprise 33% of peer-reviewed funding, compared to 7% in 2017. The maturation of the program is evident in a 24% increase in clinical trial accrual and by the awarding of NCI P01 and UH3 multi-investigator, inter- institutional grants and the only NCI T32 focused on rural cancer disparities. CP investigators are highly engaged with and responsive to the needs of MCC’s catchment area residents and are engaged in inter- programmatic research that addresses MCC’s catchment research priorities, in collaboration with Community Outreach and Engagement. Thus, the CP Program is integral to achieving the overall MCC mission to reduce the cancer burden with a focus on Kentucky and its most vulnerable populations through research, prevention, treatment, education and community engagement.