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Cancer Prevention and Control Research Program

癌症预防与控制研究计划

基本信息

批准号：
10712118
负责人：
Jerod Lynn Stapleton
金额：
$ 22.5万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-08 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10712118
关键词：
Address Adoption Affect Appalachian Region Area Award Behavioral Cancer Burden Cancer Center Cancer Center Support Grant Cancer Control Cancer Control Research Cancer Control Research Program Cancer Survivor Cancer Survivorship Caring Catchment Area Clinic Clinical Trials Collaborations Communities Community Outreach County Disclosure Dissemination and Implementation Early Diagnosis Education Electronics Ensure Environmental Exposure Evidence based intervention Financial Hardship Fostering Funding Future Genetic Markers Goals Grant Growth Health Policy Healthcare Hepatitis C Transmission Hospitals Human Genetics Human Papillomavirus Infusion procedures Intervention Intervention Studies Intervention Trial Investments Kentucky Knowledge Leadership Malignant Neoplasms Mission Modeling Molecular NCI Center for Cancer Research Obesity Oncology Outcome Patient-Focused Outcomes Patients Peer Review Pilot Projects Policies Policy Research Population Sciences Population Study Prevention Prevention Guidelines Prevention program Process Public Health Quality of life Radon Regulation Research Research Personnel Research Priority Resources Risk Risk Factors Rural Science Science Policy Screening for cancer Smokeless Tobacco Survivors Technology Testing Tobacco Tobacco Use Cessation Translating Treatment Efficacy Universities Vulnerable Populations Work Youth cancer care cancer health disparity cancer prevention cancer risk carcinogenicity cellular oncology college community engaged research community engagement design efficacy testing ethnic minority population genetic association genetic epidemiology implementation intervention implementation research implementation science implementation trial improved innovation inter-institutional lung cancer screening malignant oropharynx neoplasm member molecular marker molecular oncology novel oncology program population based prevent programs racial minority population recruit risk stratification routine care screening guidelines screening program smoke-free policy success survivorship tobacco control tobacco flavor tobacco products tobacco regulation translational oncology translational pipeline treatment risk

项目摘要

PROJECT SUMMARY/ABSTRACT Markey Cancer Center’s (MCC) Cancer Prevention and Control (CP) Research Program fosters high- impact, population-based and community-engaged research with the overarching goal of reducing cancer disparities in Kentucky. CP research spans the population science translation pipeline from advancing understanding of risk factors and intervention targets, to developing and testing new interventions, to studying the process of dissemination and implementation of evidence-based interventions into practice. Impactful scientific contributions include genetic associations of human papillomavirus and patient survival in oropharyngeal cancer, timely regulatory and policy research on novel smokeless tobacco products, trials of innovative interventions to reduce carcinogenic environmental exposures, trials of interventions to promote quality of life outcomes among rural cancer survivors, and community implementation trials to prevent hepatitis C transmission and implement cancer prevention and screening guidelines in communities throughout Kentucky and Appalachia. CP impact also extends to public health policy within Kentucky and nationally, and in advancing standards of care related to tobacco cessation and lung cancer screening. The CP Program combines these strengths to address three Aims: Advance the understanding of risk factors and intervention targets for cancer prevention and control (Aim 1); Develop and test the efficacy of interventions across the cancer control continuum (Aim 2); Study the dissemination and implementation of evidence-based interventions (Aim 3). The CP Program has been transformed by substantial strategic investments that have led to new leadership and by the infusion of multiple recruitments that have expanded the breadth and depth of program research, combined with the continued success of long-standing program members. The program’s peer-reviewed funding has increased by 50%, and NCI funding has grown dramatically by 567% to now comprise 33% of peer-reviewed funding, compared to 7% in 2017. The maturation of the program is evident in a 24% increase in clinical trial accrual and by the awarding of NCI P01 and UH3 multi-investigator, inter- institutional grants and the only NCI T32 focused on rural cancer disparities. CP investigators are highly engaged with and responsive to the needs of MCC’s catchment area residents and are engaged in inter- programmatic research that addresses MCC’s catchment research priorities, in collaboration with Community Outreach and Engagement. Thus, the CP Program is integral to achieving the overall MCC mission to reduce the cancer burden with a focus on Kentucky and its most vulnerable populations through research, prevention, treatment, education and community engagement.

项目概要/摘要马基癌症中心 (MCC) 癌症预防和控制 (CP) 研究计划培养高水平以减少癌症为总体目标的影响力、基于人群和社区参与的研究肯塔基州的差距。 CP 研究跨越了人口科学翻译管道了解风险因素和干预目标，开发和测试新的干预措施，研究将循证干预措施传播并付诸实践的过程。有影响力科学贡献包括人乳头瘤病毒与患者生存的遗传关联口咽癌、新型无烟烟草制品的及时监管和政策研究、试验减少致癌环境暴露的创新干预措施、促进干预措施的试验农村癌症幸存者的生活质量以及预防肝炎的社区实施试验 C 传播并在整个社区实施癌症预防和筛查指南肯塔基州和阿巴拉契亚。 CP 的影响还延伸到肯塔基州和全国的公共卫生政策，提高与戒烟和肺癌筛查相关的护理标准。 CP计划结合这些优势来实现三个目标：增进对风险因素和干预措施的理解癌症预防和控制目标（目标1）；制定并测试整个干预措施的有效性癌症控制连续体（目标 2）；研究基于证据的传播和实施干预（目标 3）。 CP 计划已通过大量战略投资发生了转变，这些投资已带来了新的领导层，并进行了多次招聘，扩大了工作的广度和深度计划研究，加上长期计划成员的持续成功。该计划的同行评审资金增加了 50%，NCI 资金迄今为止大幅增加了 567% 占同行评审资金的 33%，而 2017 年为 7%。该计划的成熟度体现在临床试验应计增加 24%，并且通过授予 NCI P01 和 UH3 多研究者、机构拨款和唯一关注农村癌症差异的 NCI T32。 CP调查员高度参与并响应 MCC 服务区居民的需求，并参与与社区合作，解决 MCC 流域研究优先事项的计划性研究外展和参与。因此，CP 计划对于实现 MCC 减少污染的整体使命至关重要。通过研究、预防、重点关注肯塔基州及其最弱势群体的癌症负担治疗、教育和社区参与。