The Physiological Basis for Obesity Therapeutics

肥胖治疗的生理基础

• 批准号: 7747639
• 负责人: Paul S. Maclean
• 金额: $ 1.8万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7747639
• 关键词: Adult; Affect; Basic Science; Body Weight; Clinic; Clinical; Colorado; Combined Modality Therapy; Development; Effectiveness; Fostering; Funding; Homeostasis; Individual; Nutritional; Obesity; Overweight; Pharmacologic Substance; Physiological; Population; Regulation; Research; Research Personnel; Scientist; System; Therapeutic; Work; base; biological systems; effective therapy; improved; meetings; symposium

DESCRIPTION (provided by applicant): This application seeks partial funding for a FASEB Summer Research Conference on: "The Physiological Basis for Obesity Therapeutics." The objectives of this conference are: 1. To present and discuss the key aspects of body weight regulation from an integrative perspective, and how aspects of homeostatic and non-homeostatic regulation might differ in specific populations; 2. To present and discuss how current therapies and those in development affect these regulatory systems, and how they might be used in combination to improve their general effectiveness and/or targeted to specific populations in which they may be more effective; 3. To foster the development of junior scientists and clinicians who study the mechanisms of body weight regulation and the treatment of obese individuals. The conference will be held in Snowmass Village, Colorado, from August 16th to 21st, 2009. With this conference we will attempt to establish a forum for interaction between basic science researchers and clinical strategists to work together to develop better, more effective therapies to treat obesity. The biological systems regulating energy homeostasis are inherently redundant, and there are nuances in body weight regulation in specific groups of individuals. We have yet to fully capitalize on the redundancy with combination therapies or the presence of these nuances with targeted therapies. Scientists from academic, nutritional, and pharmaceutical sectors will meet at this conference and begin to bridge this gap between the basic sciences and the clinic. NARRATIVE: Over 60% of adults are overweight or obese, and current therapeutic approaches are not very effective. This conference will provide a forum for scientists to discuss a more comprehensive perspective of obesity therapeutics that involves targeting combinational strategies to specific populations.

描述(由申请者提供)：本申请寻求为FASE B夏季研究会议提供部分资金：“肥胖治疗的生理基础”。本次会议的目标是：1.从综合的角度介绍和讨论体重调节的关键方面，以及稳态和非稳态调节在特定人群中可能存在的不同方面；2.介绍和讨论当前和正在开发的疗法如何影响这些调节系统，以及如何将它们结合使用来提高其总体有效性和/或针对特定人群更有效；3.促进初级科学家和临床医生的发展，他们研究体重调节的机制和肥胖症的治疗。大会将于2009年8月16日至21日在科罗拉多州的斯诺马斯村举行。通过这次会议，我们将尝试在基础科学研究人员和临床战略家之间建立一个互动的论坛，共同努力开发更好、更有效的治疗肥胖症的方法。调节能量动态平衡的生物系统天生是多余的，在特定的个体群体中，体重调节存在细微差别。 我们还没有充分利用联合治疗的冗余，或者靶向治疗中这些细微差别的存在。来自学术、营养和制药部门的科学家将在这次会议上汇聚一堂，开始弥合基础科学和临床之间的这一差距。 叙述：超过60%的成年人超重或肥胖，目前的治疗方法并不是很有效。这次会议将为科学家提供一个论坛，让他们讨论肥胖治疗的更全面的视角，包括针对特定人群的组合策略。