The Physiological Basis for Obesity Therapeutics

肥胖治疗的生理基础

• 批准号: 7747639
• 负责人: Paul S. Maclean
• 金额: $ 1.8万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7747639
• 关键词: Adult; Affect; Basic Science; Body Weight; Clinic; Clinical; Colorado; Combined Modality Therapy; Development; Effectiveness; Fostering; Funding; Homeostasis; Individual; Nutritional; Obesity; Overweight; Pharmacologic Substance; Physiological; Population; Regulation; Research; Research Personnel; Scientist; System; Therapeutic; Work; base; biological systems; effective therapy; improved; meetings; symposium

DESCRIPTION (provided by applicant): This application seeks partial funding for a FASEB Summer Research Conference on: "The Physiological Basis for Obesity Therapeutics." The objectives of this conference are: 1. To present and discuss the key aspects of body weight regulation from an integrative perspective, and how aspects of homeostatic and non-homeostatic regulation might differ in specific populations; 2. To present and discuss how current therapies and those in development affect these regulatory systems, and how they might be used in combination to improve their general effectiveness and/or targeted to specific populations in which they may be more effective; 3. To foster the development of junior scientists and clinicians who study the mechanisms of body weight regulation and the treatment of obese individuals. The conference will be held in Snowmass Village, Colorado, from August 16th to 21st, 2009. With this conference we will attempt to establish a forum for interaction between basic science researchers and clinical strategists to work together to develop better, more effective therapies to treat obesity. The biological systems regulating energy homeostasis are inherently redundant, and there are nuances in body weight regulation in specific groups of individuals. We have yet to fully capitalize on the redundancy with combination therapies or the presence of these nuances with targeted therapies. Scientists from academic, nutritional, and pharmaceutical sectors will meet at this conference and begin to bridge this gap between the basic sciences and the clinic. NARRATIVE: Over 60% of adults are overweight or obese, and current therapeutic approaches are not very effective. This conference will provide a forum for scientists to discuss a more comprehensive perspective of obesity therapeutics that involves targeting combinational strategies to specific populations.

描述（由申请人提供）：本申请为FASEB关于“肥胖治疗的生理基础”的夏季研究会议寻求部分资金。本次会议的目标是：1。从综合角度介绍和讨论体重调节的关键方面，以及体内平衡和非体内平衡调节在特定人群中的差异；2. 介绍和讨论目前的治疗方法和正在开发的治疗方法如何影响这些调节系统，以及它们如何联合使用以提高其总体有效性和/或针对特定人群，使其可能更有效；3. 培养研究体重调节机制和肥胖个体治疗的初级科学家和临床医生。会议将于2009年8月16日至21日在科罗拉多州的斯诺马斯村举行。通过这次会议，我们将尝试建立一个论坛，让基础科学研究人员和临床战略家之间进行互动，共同开发更好、更有效的治疗肥胖的方法。调节能量稳态的生物系统本质上是冗余的，并且在特定人群中体重调节存在细微差别。