The Physiological Basis for Obesity Therapeutics

肥胖治疗的生理基础

• 批准号: 7747639
• 负责人: Paul S. Maclean
• 金额: $ 1.8万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7747639
• 关键词: Adult; Affect; Basic Science; Body Weight; Clinic; Clinical; Colorado; Combined Modality Therapy; Development; Effectiveness; Fostering; Funding; Homeostasis; Individual; Nutritional; Obesity; Overweight; Pharmacologic Substance; Physiological; Population; Regulation; Research; Research Personnel; Scientist; System; Therapeutic; Work; base; biological systems; effective therapy; improved; meetings; symposium

DESCRIPTION (provided by applicant): This application seeks partial funding for a FASEB Summer Research Conference on: "The Physiological Basis for Obesity Therapeutics." The objectives of this conference are: 1. To present and discuss the key aspects of body weight regulation from an integrative perspective, and how aspects of homeostatic and non-homeostatic regulation might differ in specific populations; 2. To present and discuss how current therapies and those in development affect these regulatory systems, and how they might be used in combination to improve their general effectiveness and/or targeted to specific populations in which they may be more effective; 3. To foster the development of junior scientists and clinicians who study the mechanisms of body weight regulation and the treatment of obese individuals. The conference will be held in Snowmass Village, Colorado, from August 16th to 21st, 2009. With this conference we will attempt to establish a forum for interaction between basic science researchers and clinical strategists to work together to develop better, more effective therapies to treat obesity. The biological systems regulating energy homeostasis are inherently redundant, and there are nuances in body weight regulation in specific groups of individuals. We have yet to fully capitalize on the redundancy with combination therapies or the presence of these nuances with targeted therapies. Scientists from academic, nutritional, and pharmaceutical sectors will meet at this conference and begin to bridge this gap between the basic sciences and the clinic. NARRATIVE: Over 60% of adults are overweight or obese, and current therapeutic approaches are not very effective. This conference will provide a forum for scientists to discuss a more comprehensive perspective of obesity therapeutics that involves targeting combinational strategies to specific populations.

描述（由申请人提供）：本申请为FASEB夏季研究会议寻求部分资金：“肥胖治疗的生理基础”。这次会议的目标是：1。从综合的角度介绍和讨论体重调节的关键方面，以及体内平衡和非固态调节的方面在特定人群中如何有所不同； 2。介绍并讨论当前的疗法和发展中的疗法如何影响这些监管系统，以及它们如何合并使用它们来提高其一般效率和/或针对可能更有效的特定人群； 3。促进研究体重调节机制和肥胖个体治疗机制的初级科学家和临床医生的发展。该会议将于2009年8月16日至21日在科罗拉多州的雪摩斯村举行。通过本次会议，我们将尝试建立一个基础科学研究人员和临床战略家之间互动的论坛，以共同努力，以开发更好，更有效的治疗肥胖治疗方法。调节能量稳态的生物系统本质上是多余的，并且特定个体组的体重调节有细微差别。 我们尚未充分利用组合疗法的冗余或针对性疗法的这些细微差别。学术，营养和药品部门的科学家将在本次会议上开会，并开始弥合基础科学与诊所之间的这一差距。 叙述：超过60％的成年人超重或肥胖，当前的治疗方法不是很有效。这次会议将为科学家提供一个论坛，以讨论肥胖治疗剂的更全面的观点，涉及将组合策略靶向特定人群。