Function of biphasic sleep in infants

婴儿双相睡眠的功能

• 批准号: 10719242
• 负责人: Rebecca M C Spencer
• 金额: $ 40.74万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-05 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10719242
• 关键词: Age; Architecture; Brain; Caregivers; Characteristics; Child; Cognitive; Data; Development; Electroencephalography; Family; Frequencies; Goals; Guidelines; Individual; Individual Differences; Infant; Infant Development; Intervention; Learning; Measures; Memory; Napping; Outcome; Parents; Participant; Performance; Phase; Physiological; Polysomnography; Process; Proxy; Recommendation; Research; Research Design; Role; Scientist; Sleep; Sleep Stages; Slow-Wave Sleep; Source; Stress; Testing; Time; Work; actigraphy; awake; cognitive development; density; infancy; insight; memory consolidation; non rapid eye movement; pediatrician; preservation; recruit; sleep abnormalities; sleep pattern; sleep physiology; sleep regulation; sleep spindle; targeted treatment; word learning

PROJECT SUMMARY Sleep is critical for infant physical and cognitive development and yet understanding sleep time and timing is a source of stress to parents and families. Thus a better understanding of when infants sleep, specifically the transition from two to one naps, will support infant cognitive development and contribute to guidance for families. The objective of the proposed research is to examine, longitudinally, the role of multiple sleep bouts in memory consolidation across the triphasic to biphasic sleep transition in infancy. The overarching hypothesis is that naps maintain their usefulness across these transitions, but that multiple naps become less essential to the preservation of memories as infants naturally transition to one nap per day. More specifically, it is predicted that memories can be held longer without interference as the child develops across this age range, making the morning nap less essential to memory while the afternoon nap remains essential. Participants will be 100 infants, who will complete 2 sessions, a sleep and a wake session, every three months (9, 12, and, 15 months). A deferred imitation task will be used to assess nap-related changes in memory consolidation. Actigraphy will be used to objectively assess nap habituality. Polysomnography will be used to understand the physiological mechanism underlying memory benefits and it will also provide a proxy for brain development. Collectively, the work will (1) assess memory consolidation over morning and afternoon nap intervals across the triphasic to biphasic sleep transition in infants; (2) examine the mechanism supporting declarative memory consolidation in infancy; and (3) establish the developmental trajectory of key sleep physiology features within naps across this developmental age range. An exploratory aim will examine whether changes in estimated brain development predict the triphasic to biphasic sleep transition. The outcomes have theoretical significance. These results will be significant for the field of sleep research, providing critical insight into development of sleep regulation processes and longitudinal changes in sleep patterns. Additionally, results will be informative to developmental scientists, suggesting that the timing of studies will contribute to performance. The outcomes also have translational significance. A better understanding of nap transitions will inform pediatricians and parents as they make recommendations and decisions about infant sleep and allow for identification of infants with abnormal sleep development trajectories.

项目摘要 睡眠对于婴儿的身体和认知发展至关重要，但是了解睡眠时间和时机是一个 给父母和家庭压力的根源。因此，更好地理解婴儿何时入睡，特别是 从两次到一个小睡，将支持婴儿的认知发展，并为家庭提供指导。 拟议的研究的目的是纵向研究多次睡眠回合在记忆中的作用 在婴儿期到双相睡眠过渡的整合。总体假设是小睡 在这些转变中保持其有用性，但是多次小睡对 保存记忆作为婴儿自然过渡到每天一次小睡。更具体地说，可以预测 随着孩子在这个年龄范围内成长，记忆可以保持更长的时间，而不会干扰，这使得 午睡对记忆的必要较少，而下午的午睡仍然是必不可少的。参与者将是100名婴儿， 谁将每三个月（9、12和15个月）完成2次，睡眠和一次唤醒课程。一个 延期模仿任务将用于评估与小睡相关的内存整合变化。动作学将是 用于客观地评估午睡的习惯性。多摄影学将用于了解生理 记忆益处的基本机制，它也将为大脑发育提供代理。集体， 工作将（1）评估在三倍体的早晨和下午的午睡间隔内评估记忆整合到 婴儿的双相睡眠过渡； （2）检查支持声明记忆巩固的机制 婴儿期； （3）在此期间NAPS内建立关键睡眠生理特征的发育轨迹 发展年龄范围。探索目的将检查估计大脑发育的变化是否 预测三重到双相睡眠过渡。结果具有理论意义。这些结果将会 对于睡眠研究领域非常重要，为睡眠调节的发展提供了批判性的见解 睡眠模式的过程和纵向变化。此外，结果将为发展提供信息 科学家们表明，研究时间将有助于表现。结果也有 翻译意义。更好地了解午睡过渡将为儿科医生和父母提供信息 做出有关婴儿睡眠的建议和决定，允许鉴定出异常的婴儿 睡眠发育轨迹。