Sleep-dependent Memory Processing in Older Adults

老年人睡眠依赖性记忆处理

• 批准号: 8531122
• 负责人: Rebecca M C Spencer
• 金额: $ 30.46万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531122
• 关键词: Accounting; Age; Age-associated memory impairment; Aging; Animal Model; Circadian Rhythms; Cognition; Cognitive; Cognitive aging; Cognitive deficits; Data; Development; Disease; Elderly; Exhibits; Goals; Health; Hippocampus (Brain); Impaired cognition; Individual; Knowledge; Learning; Longevity; Measures; Memory; Mission; Motor; Outcome; Performance; Physiological; Physiology; Polysomnography; Population; Population Control; Prevention strategy; Process; Property; Public Health; Relative (related person); Research; Role; Science; Sleep; Sleep Disorders; Sleep Stages; Sleep disturbances; Slow-Wave Sleep; Structure; Techniques; Testing; United States National Institutes of Health; Work; age related; base; disability; healthy aging; innovation; insight; juvenile animal; memory process; neocortical; neurophysiology; novel; procedural memory; public health relevance; sequence learning; treatment strategy; young adult

DESCRIPTION (provided by applicant): Healthy aging is accompanied by decreased cognitive abilities and a parallel decline in sleep quantity and quality. Given a wealth of researc in healthy young adults and animal models illustrating a benefit of sleep on memory and other cognitive processes, our overarching objective is to understand whether changes in sleep may account for changes in cognitive abilities in healthy aging. The specific objective of this application is to probe whether learning is benefitted by sleep in healthy older adults as compared to healthy young adults. In addition to probing memory following intervals of sleep and wake, we will investigate whether the memories were restructured over sleep and the neurophysiological underpinnings of observed changes. Sleep's function on declarative and procedural learning is unique, each being associated with distinct sleep stages and physiological markers. Therefore, we will separately probe declarative and procedural learning. In Specific Aim 1 we will examine whether procedural memories are benefitted by sleep in older adults. Preliminary data suggests an age-related decline in sleep-dependent memory consolidation for such tasks, a deficit we predict is associated with fragmentation of the critical sleep stage. In Specific Aim 2 we will examine whether declarative memories are benefitted by sleep in healthy older adults. Preliminary data suggest that declarative memory performance of older adults is greater following sleep relative to wake, similar to young adults. We will probe whether this result reflects a reorganization of the memory and whether it is a general property of the declarative memory domain. The proposed research is innovative as it applies a novel concept to the field of cognitive aging, utilizes novels techniques (polysomnography) for this field, and seeks to shift the treatment and preventive strategies for age-related cognitive deficit to sleep targets. Moreover, the proposed work is significant in advancing our understanding of cognitive deficits in other diseases in which sleep disturbances are frequently observed by describing the scope of the sleep-cognition relationship in the control population.

描述（由申请人提供）：健康衰老伴随着认知能力的降低以及睡眠数量和质量平行下降。鉴于健康的年轻人和动物模型中有大量的研究表明睡眠对记忆和其他认知过程的好处，我们的总体目标是了解睡眠变化是否可能解释健康衰老的认知能力的变化。本应用的具体目标是探测健康的老年人与健康的年轻人相比，在健康的老年人中学习是否受益。除了在睡眠和唤醒的间隔内探测记忆外，我们还将调查记忆是否在睡眠中进行了重组以及观察到的变化的神经生理基础。睡眠在声明性学习和程序学习上的功能是独一无二的，每种都与不同的睡眠阶段和生理标记有关。因此，我们将分别探究声明和程序学习。在特定的目标1中，我们将检查过程记忆是否会受益于老年人睡眠。初步数据表明，对于此类任务的睡眠依赖性记忆巩固与年龄相关的下降，我们预测的赤字与关键的分裂有关 睡眠阶段。在特定的目标2中，我们将检查健康的老年人睡眠是否受益于宣言性记忆。初步数据表明，与唤醒相似的睡眠后，老年人的声明性记忆表现较大，类似于年轻人。我们将探测该结果是否反映了内存的重组以及它是否是声明性内存域的一般属性。拟议的研究具有创新性，因为它将新颖的概念应用于认知衰老领域，利用该领域的小说技术（多性评估），并试图将与年龄相关的认知不足的治疗和预防策略转移到睡眠目标上。此外，拟议的工作对于推进我们对其他疾病认知缺陷的理解非常重要，在这些疾病中，通过描述对照人群中睡眠认知关系的范围，经常观察到睡眠障碍。