Behavior & Clinical Trials Participation in HIV+ Latinos

描述（由申请人提供）：通过这项研究职业发展奖励，我将完成初步步骤，建立自己作为一个独立的研究人员在艾滋病毒/艾滋病行为研究，以减少拉丁裔社区感染艾滋病毒的健康差距。通过教学和指导学习，我将改进我现有的行为、定性和定量研究技能，以解决拉丁裔社区艾滋病临床试验参与率低的问题。研究试验中少数民族人口的比例代表是必要的，以提高研究能力，将结果推广到感染艾滋病毒的不同人群。我的具体研究目标是：1)描述和理解的态度，信仰，文化和社会规范，提供者和系统的影响有关进入临床试验的HIV+墨西哥裔拉丁美洲人，和2)开发和试点测试的干预措施，以提高理解和接受HIV+墨西哥裔拉丁美洲人和他们的社区参与临床试验。研究计划的理论框架是卫生服务使用行为模型（Andersen, Aday, et al.）。研究计划将分三个阶段进行，每个阶段都与职业发展目标和活动有关。在第一阶段，我将使用定性方法对艾滋病毒+墨西哥裔拉丁美洲人进行形成性研究，包括设计和实施深度访谈协议和焦点小组问题，以探讨在尝试提高拉丁裔人群临床试验参与时需要考虑的因素。在第二阶段，我将进行定性分析，建立参与研究的社会认知模型，提出研究假设，并开发和试点测试一项调查，以测试HIV+墨西哥裔拉丁美洲人的社会认知模型。在第三阶段，我将验证调查，分析和报告结果，设计和试点测试一种行为干预措施，以增加艾滋病毒+墨西哥裔拉丁美洲人的临床试验参与，最后，使用干预试点数据向NIH准备R01提案，以促进艾滋病毒+拉丁美洲人参与临床试验。

DESCRIPTION (provided by applicant): Through this research career development award, I will complete the initial steps to establish myself as an independent researcher in HIV/AIDS behavioral research to reduce health disparities in Latino communities infected with HIV. Using didactic and mentored learning, I will improve upon my existing behavioral, qualitative, and quantitative research skills to address the issue of low participation in HIV/AIDS clinical trials in Latino communities. Proportionate representation of minority populations in research trials is necessary to improve research capacity to generalize results to diverse populations infected with HIV. My specific research aims are to: 1) Describe and understand the attitudes, beliefs, cultural and social norms, provider and system influences relating to entry into clinical trials in HIV+ Mexican-origin Latinos, and 2) Develop and pilot test an intervention for improving understanding and acceptance of HIV clinical trials participation by HIV+ Mexican-origin Latinos and their communities. The theoretical framework of the research plan is the Behavioral Model of Health Services Use (Andersen, Aday, et al.). The research plan will be carried out in three phases, each phase linked to a career development objective and activity. In Phase 1 I will conduct formative research using qualitative methods with HIV+ Mexican-origin Latinos, including design and implementation of an in-depth interview protocol and focus group questions to explore factors to consider in attempting to improve clinical trials participation in Latino populations. In Phase 2 I will carry out qualitative analysis, develop a social cognitive model of participation in research, develop research hypotheses, and develop and pilot test a survey to test the social cognitive model in HIV+ Mexican-origin Latinos. In Phase 3 I will validate the survey, analyze and report outcomes, design and pilot-test a behavioral intervention to increase clinical trials participation in HIV+ Mexican-origin Latinos, and finally, use intervention pilot data to prepare an R01 proposal to the NIH to promote participation of HIV+ Latinos in clinical trials.