Behavior & Clinical Trials Participation in HIV+ Latinos

通过这项研究职业发展奖，我将完成初步步骤，建立自己作为一个独立的研究人员在艾滋病毒/艾滋病行为研究，以减少健康差距在拉丁美洲社区感染艾滋病毒。使用教学和指导学习，我将提高我现有的行为，定性和定量研究技能，以解决在拉丁美洲社区艾滋病毒/艾滋病临床试验参与率低的问题。少数群体在研究试验中的比例代表性对于提高研究能力以将结果推广到感染艾滋病毒的不同群体是必要的。我的具体研究目标是：1）描述和了解的态度，信仰，文化和社会规范，供应商和系统的影响，进入艾滋病毒+墨西哥裔拉丁美洲人的临床试验，和2）开发和试点测试的干预措施，以提高艾滋病毒+墨西哥裔拉丁美洲人及其社区参与艾滋病毒临床试验的理解和接受。研究计划的理论框架是卫生服务使用行为模型（Andersen，Aday等人）。研究计划将分三个阶段进行，每个阶段都与职业发展目标和活动有关。在第1阶段，我将使用定性方法对HIV+墨西哥裔拉丁美洲人进行形成性研究，包括设计和实施深入访谈方案和焦点小组问题，以探索在试图改善拉丁美洲人群临床试验参与时应考虑的因素。在第2阶段，我将进行定性分析，开发参与研究的社会认知模型，开发研究假设，并开发和试点测试一项调查，以测试艾滋病毒+墨西哥裔拉丁美洲人的社会认知模型。在第三阶段，我将验证调查，分析和报告结果，设计和试点测试行为干预，以增加艾滋病毒+墨西哥裔拉丁美洲人的临床试验参与，最后，使用干预试点数据准备向NIH提交R 01提案，以促进艾滋病毒+拉丁美洲人参与临床试验。

DESCRIPTION (provided by applicant): Through this research career development award, I will complete the initial steps to establish myself as an independent researcher in HIV/AIDS behavioral research to reduce health disparities in Latino communities infected with HIV. Using didactic and mentored learning, I will improve upon my existing behavioral, qualitative, and quantitative research skills to address the issue of low participation in HIV/AIDS clinical trials in Latino communities. Proportionate representation of minority populations in research trials is necessary to improve research capacity to generalize results to diverse populations infected with HIV. My specific research aims are to: 1) Describe and understand the attitudes, beliefs, cultural and social norms, provider and system influences relating to entry into clinical trials in HIV+ Mexican-origin Latinos, and 2) Develop and pilot test an intervention for improving understanding and acceptance of HIV clinical trials participation by HIV+ Mexican-origin Latinos and their communities. The theoretical framework of the research plan is the Behavioral Model of Health Services Use (Andersen, Aday, et al.). The research plan will be carried out in three phases, each phase linked to a career development objective and activity. In Phase 1 I will conduct formative research using qualitative methods with HIV+ Mexican-origin Latinos, including design and implementation of an in-depth interview protocol and focus group questions to explore factors to consider in attempting to improve clinical trials participation in Latino populations. In Phase 2 I will carry out qualitative analysis, develop a social cognitive model of participation in research, develop research hypotheses, and develop and pilot test a survey to test the social cognitive model in HIV+ Mexican-origin Latinos. In Phase 3 I will validate the survey, analyze and report outcomes, design and pilot-test a behavioral intervention to increase clinical trials participation in HIV+ Mexican-origin Latinos, and finally, use intervention pilot data to prepare an R01 proposal to the NIH to promote participation of HIV+ Latinos in clinical trials.