Behavior & Clinical Trials Participation in HIV+ Latinos

行为

• 批准号: 7407454
• 负责人: Maria Luisa Zuniga de Nuncio
• 金额: $ 12.03万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-25 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7407454
• 关键词: AIDS/HIV problem; Address; Area; Attitude; Award; Behavior; Behavior Therapy; Behavioral; Behavioral Model; Behavioral Research; Belief; Clinical Trials; Code; Cognitive; Communities; Data; Depth; Development; Economics; Focus Groups; HIV; Health Services; Hispanics; Intervention; Interview; K-Series Research Career Programs; Latino; Learning; Link; Measures; Mentors; Mexican; Minority; Modeling; National Institute of Mental Health; Outcome; Persons; Phase; Population; Population Heterogeneity; Principal Investigator; Process; Protocols documentation; Provider; Qualitative Methods; Qualitative Research; Readiness; Reporting; Research; Research Personnel; Sampling; Series; Surveys; System; Target Populations; Testing; United States National Institutes of Health; Woman; Work; Writing; base; career; design; experience; health disparity; improved; instrument; men; skills; social; theories; therapy design

DESCRIPTION (provided by applicant): Through this research career development award, I will complete the initial steps to establish myself as an independent researcher in HIV/AIDS behavioral research to reduce health disparities in Latino communities infected with HIV. Using didactic and mentored learning, I will improve upon my existing behavioral, qualitative, and quantitative research skills to address the issue of low participation in HIV/AIDS clinical trials in Latino communities. Proportionate representation of minority populations in research trials is necessary to improve research capacity to generalize results to diverse populations infected with HIV. My specific research aims are to: 1) Describe and understand the attitudes, beliefs, cultural and social norms, provider and system influences relating to entry into clinical trials in HIV+ Mexican-origin Latinos, and 2) Develop and pilot test an intervention for improving understanding and acceptance of HIV clinical trials participation by HIV+ Mexican-origin Latinos and their communities. The theoretical framework of the research plan is the Behavioral Model of Health Services Use (Andersen, Aday, et al.). The research plan will be carried out in three phases, each phase linked to a career development objective and activity. In Phase 1 I will conduct formative research using qualitative methods with HIV+ Mexican-origin Latinos, including design and implementation of an in-depth interview protocol and focus group questions to explore factors to consider in attempting to improve clinical trials participation in Latino populations. In Phase 2 I will carry out qualitative analysis, develop a social cognitive model of participation in research, develop research hypotheses, and develop and pilot test a survey to test the social cognitive model in HIV+ Mexican-origin Latinos. In Phase 3 I will validate the survey, analyze and report outcomes, design and pilot-test a behavioral intervention to increase clinical trials participation in HIV+ Mexican-origin Latinos, and finally, use intervention pilot data to prepare an R01 proposal to the NIH to promote participation of HIV+ Latinos in clinical trials.

描述（由申请人提供）：通过这项研究职业发展奖，我将完成初步步骤，使自己成为艾滋病毒/艾滋病行为研究的独立研究员，以减少感染艾滋病毒的拉丁裔社区的健康差距。通过教学和指导学习，我将提高我现有的行为、定性和定量研究技能，以解决拉丁裔社区艾滋病毒/艾滋病临床试验参与率低的问题。研究试验中少数民族人口的比例是必要的，以提高研究能力，将结果推广到感染艾滋病毒的不同人群。我的具体研究目标是：1) 描述和了解与 HIV+ 墨西哥裔拉丁裔参加临床试验相关的态度、信仰、文化和社会规范、提供者和系统影响，以及 2) 制定并试点测试一项干预措施，以提高 HIV+ 墨西哥裔拉丁裔及其社区对参与 HIV 临床试验的理解和接受度。该研究计划的理论框架是健康服务使用行为模型（Andersen、Aday 等人）。该研究计划将分三个阶段进行，每个阶段都与职业发展目标和活动相关。在第一阶段，我将使用定性方法对 HIV+ 墨西哥裔拉丁裔进行形成性研究，包括设计和实施深入访谈方案和焦点小组问题，以探索在尝试提高拉丁裔人群临床试验参与度时需要考虑的因素。在第二阶段，我将进行定性分析，开发参与研究的社会认知模型，提出研究假设，并开发和试点测试一项调查，以测试艾滋病毒+墨西哥裔拉丁美洲人的社会认知模型。在第 3 阶段，我将验证调查、分析和报告结果、设计和试点测试行为干预措施，以增加 HIV+ 墨西哥裔拉丁美洲人的临床试验参与度，最后，利用干预试点数据向 NIH 准备 R01 提案，以促进 HIV+ 拉丁美洲人参与临床试验。