A Population-Based Latinx Community Study of Alzheimer’s Disease

摘要 美国的老年拉丁裔成年人患阿尔茨海默病（AD）和相关疾病的风险更大。 痴呆症（ADRD）。他们表现出比非西班牙裔白人更快的认知能力下降。然而，他们仍然 在表征与渐进性认知障碍相关的风险因素的研究中， 下降更好地了解危险因素可以提供更好的治疗和设计适当的预防措施 老年拉丁裔成年人的策略。由于老年拉丁美洲成年人有较高的心血管疾病风险的患病率 由于这些因素，老年人发生ADRD的风险很高。老年拉丁裔社区不成比例地 受COVID-19大流行影响，这可能会增加他们患神经系统疾病的风险。UH2/UH3 合作协议旨在参与和发展基础设施，为一个新的拉丁美洲队列研究与 以下目标：（1）建立基础设施，社区外展，和外部咨询委员会，为一个新的拉丁 队列;（2）制定与社区和资源共享计划的持续参与;（3）收集以下数据： 来自东区抽样框架的250名Latinx参与者;以及（4）测试Latinx 参与者的临床诊断AD和MCI患病率较高，COVID-19对AD的影响 与非西班牙裔白人相比更严重，ApoE 4与临床AD和MCI的相关性是 和NHW一样。长期目标是进行一项大规模的多种族研究，结合拉丁裔队列 与我们现有的芝加哥健康和老龄化项目（CHINA），一个基于人口的社区研究，在四个 社区有10，801名参与者，其中63%为非西班牙裔黑人，37%为非西班牙裔白色人 参与者这个UH 2/UH 3提案将在芝加哥的东区社区增加一个新的拉丁裔群体， 超过60%的拉丁裔一个多种族的队列将使我们能够测试几个生物和心理社会的假设， 公共卫生意义重大。生物样本的采集也将允许进一步的血液检测 生物标志物假说，开发一个组学管道，并提供额外的基础设施， 病理学研究在一个基于人群的队列研究与少数民族。

ABSTRACT Older Latinx adults in the US are at a greater risk of developing Alzheimer's disease (AD) and related dementias (ADRD). They exhibit a faster cognitive decline than non-Hispanic whites. However, they remain vastly underrepresented in research studies to characterize risk factors associated with progressive cognitive decline. A better understanding of risk factors can provide better treatment and design appropriate preventive strategies for older Latinx adults. Since older Latinx adults have a higher prevalence of cardiovascular risk factors, their risk of developing ADRD is high in old age. Older Latinx communities were disproportionately affected by the COVID-19 pandemic, which can increase their risk for neurological disorders. This UH2/UH3 cooperative agreement aims to engage and develop the infrastructure for a new Latinx cohort study with the following aims: (1) build infrastructure, community outreach, and the external advisory board for a new Latinx cohort; (2) develop ongoing engagement with the community and resource sharing plan; (3) collect data on 250 Latinx participants from East Side sampling frame; and (4) test the exploratory hypotheses that Latinx participants have a higher prevalence of clinically diagnosed AD and MCI, and the impact of COVID-19 on AD is more severe compared to non-Hispanic whites, and the ApoE4 association with clinical AD and MCI is the same as NHW. The long-term objective is to perform a sizeable muti-ethnic study, combining the Latinx cohort with our existing Chicago Health and Aging Project (CHAP), a population-based community study in four neighborhoods with 10,801 participants with 63% non-Hispanic Black and 37% non-Hispanic white participants. This UH2/UH3 proposal will add a new Latinx cohort in the East Side community of Chicago, with over 60% Latinx. A multi-ethnic cohort will allow us to test several biological and psychosocial hypotheses of high public health significance. The collection of biospecimens will also allow for testing further blood biomarker hypotheses, developing an omics pipeline down the road, and providing additional infrastructure for pathology studies in a population-based cohort study with minorities.