A Population-Based Latinx Community Study of Alzheimer’s Disease

摘要 美国拉丁裔老年人罹患阿尔茨海默病(AD)及相关疾病的风险更高 痴呆(ADRD)。他们表现出比非西班牙裔白人更快的认知衰退。然而，他们仍然 在研究与渐进性认知相关的风险因素的研究中被大大低估 拒绝。更好地了解危险因素可以提供更好的治疗和制定适当的预防措施 针对年长拉丁裔成年人的战略。由于年长的拉丁裔成年人患心血管疾病的风险更高 这些因素中，老年人发生ADRD的风险较高。较老的拉丁裔社区不成比例地 受新冠肺炎大流行的影响，这会增加他们患神经疾病的风险。此UH2/UH3 合作协议旨在参与并开发基础设施，以便与 以下目标：(1)为新的拉丁裔建立基础设施、社区外联和外部咨询委员会 队列；(2)发展与社区的持续接触和资源共享计划；(3)收集关于 来自东区的250名Latinx参与者；以及(4)检验Latinx的探索性假设 参与者临床诊断为AD和MCI的患病率较高，新冠肺炎对AD的影响 与非西班牙裔白人相比，ApoE4更严重，ApoE4与临床AD和MCI的关联是 与nhw相同。长期目标是进行一项大规模的多种族研究，结合拉丁裔队列 凭借我们现有的芝加哥健康和老龄化项目(CHAP)，一项基于人口的社区研究在四个月中 有10801名参与者的社区，其中63%是非西班牙裔黑人，37%是非西班牙裔白人 参与者。这项UH2/UH3提案将在芝加哥东区社区增加一个新的拉丁裔队列， 超过60%的拉丁裔。一个多种族的队列将使我们能够测试几个生物学和心理社会假说 具有很高的公共卫生意义。生物标本的收集也将允许进一步的血液测试 生物标记物假说，开发未来的组学管道，并提供额外的基础设施 少数民族人群队列研究中的病理学研究。

ABSTRACT Older Latinx adults in the US are at a greater risk of developing Alzheimer's disease (AD) and related dementias (ADRD). They exhibit a faster cognitive decline than non-Hispanic whites. However, they remain vastly underrepresented in research studies to characterize risk factors associated with progressive cognitive decline. A better understanding of risk factors can provide better treatment and design appropriate preventive strategies for older Latinx adults. Since older Latinx adults have a higher prevalence of cardiovascular risk factors, their risk of developing ADRD is high in old age. Older Latinx communities were disproportionately affected by the COVID-19 pandemic, which can increase their risk for neurological disorders. This UH2/UH3 cooperative agreement aims to engage and develop the infrastructure for a new Latinx cohort study with the following aims: (1) build infrastructure, community outreach, and the external advisory board for a new Latinx cohort; (2) develop ongoing engagement with the community and resource sharing plan; (3) collect data on 250 Latinx participants from East Side sampling frame; and (4) test the exploratory hypotheses that Latinx participants have a higher prevalence of clinically diagnosed AD and MCI, and the impact of COVID-19 on AD is more severe compared to non-Hispanic whites, and the ApoE4 association with clinical AD and MCI is the same as NHW. The long-term objective is to perform a sizeable muti-ethnic study, combining the Latinx cohort with our existing Chicago Health and Aging Project (CHAP), a population-based community study in four neighborhoods with 10,801 participants with 63% non-Hispanic Black and 37% non-Hispanic white participants. This UH2/UH3 proposal will add a new Latinx cohort in the East Side community of Chicago, with over 60% Latinx. A multi-ethnic cohort will allow us to test several biological and psychosocial hypotheses of high public health significance. The collection of biospecimens will also allow for testing further blood biomarker hypotheses, developing an omics pipeline down the road, and providing additional infrastructure for pathology studies in a population-based cohort study with minorities.