Project Core

项目核心

• 批准号: 10729446
• 负责人: SANDRA WEINTRAUB
• 金额: $ 100.28万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10729446
• 关键词: Address; Adherence; Adult; Affect; Age; Alzheimer' s disease related dementia; Android; Assessment tool; Attention; Behavior; Behavioral; Biosensor; Calibration; Cellular Phone; Clinic; Clinical; Cognitive; Collection; Computer software; Computers; Data; Data Analyses; Data Collection; Decision Making; Dementia; Education; Emotional; Ethnic Origin; Etiology; Future; Gait speed; General Population; Geography; Goals; Gold; Health; Hearing; Heart Rate; Impaired cognition; Incentives; Individual; Informal Social Control; Intervention; Libraries; Link; Location; Longevity; Longitudinal Studies; Measurement; Measures; Medicine; Methods; Monitor; Motivation; Participant; Patient Self-Report; Performance; Personality; Physical Function; Physiological; Population; Procedures; Process; Property; Protocols documentation; Proxy; Psychometrics; Race; Reporting; Research Design; Research Personnel; Respondent; Sampling; Schedule; Self Administration; Series; Specific qualifier value; Specificity; Stress; Testing; United States National Institutes of Health; Update; Validation; Work; biological sex; cognitive change; cognitive function; cognitive task; contextual factors; data management; design; evidence base; experience; flexibility; follow-up; health disparity; improved; incentive strategies; minority health; mobile application; mobile computing; participant retention; patient engagement; person centered; psychologic; recruit; remote assessment; response; retention rate; sensor technology; skills; social; stress reactivity; study population; theories; validation studies

Project Summary Under the renewal of the Mobile Toolbox (MTB2), the Project and Cores will work collaboratively to enhance the Mobile Toolbox (MTB) platform so that it may become a form of “common currency” for remote assessments with the flexibility to meet the needs of researchers across a vast array of diverse study designs and populations. To accomplish this, the Project will develop, integrate, and psychometrically evaluate new measures and retention strategies that will benefit future research utilizing remote assessment tools. The primary aims of the Project include: Aim 1: Identify, develop, and integrate non-cognitive measures and passive sensor technology for the Mobile Toolbox (MTB) to enable the collection of lifespan contextual, psychological, physical, and behavioral experiences to enhance the assessment of cognitive trajectories; Aim 2: Evaluate the psychometric properties of the MTB2 measures through a series of data collection protocols aimed at calibration, norming, validation, and measurement sensitivity; and Aim 3: Leverage longitudinal studies included in MTB2 to develop, integrate, and evaluate retention strategies to improve participant adherence and compliance. The measures introduced by MTB2 will be designed around the technical specifications of an open software iOS and Android platform that enables external researchers to customize a mobile app to fit their study needs. Researchers will be able to choose from a diverse selection of measures, including several change-sensitive cognitive tasks, measures of contextual and exposure variables, as well as physical, behavioral, and psychological functions. We will then calibrate new measures using Item Response Theory by administering them to a large general population sample. All newly developed measures will be validated against existing gold standards in a sample of healthy adults ages 20-85 with a 7- to 21-day retest; MTB measures will be completed in an un-proctored setting. We will also conduct a clinical validation study and identify normative values for the new MTB measures using a large, nationally representative sample. Finally, a series of hypothesis-driven studies prioritized by the NIH, Steering Committee, and External Scientific Panel will be used to explore the relationship between non-cognitive and cognitive functions across the adult lifespan. By leveraging the MTB2 longitudinal studies, we will identify dynamic motivational strategies that help sustain participant engagement, promote re-engagement, and maintain long-term study adherence. MTB2's range of evidence-based incentive strategies at both the group and person-centered level will be integrated into the researcher study portal to allow studies with diverse cross-study designs and assessment schedules to maximize engagement and retention. Special attention will be paid to retaining participants from minority health and NIH-designated populations that experience health disparities.

项目摘要 在移动的基站（MTB 2）的更新下，项目和核心将合作， 移动的平台，使其成为远程评估的“通用货币” 具有灵活性，可满足研究人员在各种不同研究设计和人群中的需求。 为了实现这一目标，该项目将开发，整合和心理测量评估新的措施， 保留战略，将有利于未来的研究利用远程评估工具。的主要目标 目标1：识别、开发和集成非认知测量和被动传感器 技术的移动的智能手机（MTB），使收集寿命的上下文，心理， 身体和行为体验，以增强对认知轨迹的评估;目标2： 通过一系列数据收集，评估MTB 2测量的心理测量特性 旨在校准、规范、验证和测量灵敏度的协议;目标3：利用 MTB 2中包含的纵向研究，用于开发、整合和评估保留策略以改进 参与者的遵守和遵从。MTB 2引入的措施将围绕以下方面进行设计： 开放式软件iOS和Android平台的技术规范，使外部研究人员能够 定制移动的应用程序以满足他们的学习需求。研究人员将能够从多种选择中选择 测量，包括几个变化敏感的认知任务，测量的背景和暴露变量， 以及生理、行为和心理功能。然后，我们将使用项目 响应理论通过管理他们到一个大的一般人群样本。所有新制定的措施 将在年龄为20-85岁的健康成人样本中根据现有的黄金标准进行验证， 重新测试; MTB测量将在非监督环境中完成。我们还将进行临床验证 研究和确定新的MTB标准值使用一个大的，全国代表性的样本。 最后，一系列由NIH、指导委员会和外部科学家优先考虑的假设驱动的研究 面板将用于探索整个成人的非认知和认知功能之间的关系 寿命通过利用MTB 2纵向研究，我们将确定动态激励策略， 维持参与者的参与，促进再参与，并保持长期的研究依从性。MTB 2的 一系列以团体和个人为中心的循证激励策略将被整合到 研究者研究门户网站，允许具有不同交叉研究设计和评估时间表的研究， 最大限度地提高参与度和保留率。将特别注意留住来自少数群体保健的参与者 和NIH指定的经历健康差异的人群。