Clinical/Imaging Core

临床/影像核心

• 批准号: 10276529
• 负责人: SANDRA WEINTRAUB
• 金额: $ 155.55万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10276529
• 关键词: Address; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Anterior; Biological; Blood specimen; Brain; Brain Diseases; Canada; Caucasians; Chronology; Clinical; Cognition; Cognitive; Cognitive aging; Data; Data Collection; Databases; Dementia; Elderly; Enrollment; Episodic memory; Extramural Activities; Funding; Genetic; Health; Illinois; Image; Infrastructure; Institutes; Investigation; Label; Life Style; Longitudinal Studies; Longitudinal prospective study; Magnetic Resonance Imaging; Memory; Memory Loss; Michigan; Neurocognitive; Neuropsychology; Ontario; Outcome; Participant; Pathway interactions; Performance; Population; Procedures; Protocols documentation; Race; Research; Research Project Grants; Resistance; Resources; Sample Size; Site; Standardization; Thick; United States; Universities; Well in self; Wisconsin; age related; aged; cerebral atrophy; cognitive reserve; cohort; data harmonization; data management; impression; inclusion criteria; multidisciplinary; outreach; participant enrollment; peer; psychosocial; racial diversity; recruit; resilience; resistance mechanism; social relationships; wearable sensor technology

PROJECT SUMMARY (Clinical / Imaging): Memory complaints are widespread among the elderly and aging is a major risk factor for Alzheimer's disease (AD), leading to the impression that a gradual loss of memory ability, eventually culminating in dementia, may be a nearly universal consequence of getting old. This Consortium will explore an alternative aging trajectory by studying 80+ year-olds that we have labelled `SuperAgers', who have episodic memory performance that appears to have escaped age-related decline and that remains in the range that is at least normal for 50-60- year-olds and. The study of SuperAgers was initiated at Northwestern University and will be extended through this Consortium. The Clinical/Imaging Core of the SuperAging Consortium will establish standardized inclusion criteria and uniform assessments for the harmonized cross-site characterization of SuperAgers and their Controls. Aim 1 will coordinate enrollment and harmonized data collection on at least 500 participants (300 SuperAgers, 200 Controls) across the United States and Canada into a prospective longitudinal study, which includes health, lifestyle, and neurocognitive assessments, as well as MR imaging, blood samples, and eventual brain donation. Particular emphasis will be placed on enhancing recruitment of diverse participants from Sites with strengths in recruitment and sophisticated characterization of older adults. Aim 2 will support studies that confirm and extend previous findings in a larger and more diverse cohort as well as identification of new factors associated with unusually successful aging. Aim 3 will launch new directions of investigation through the support of the two Projects associated with this Consortium and collaborative investigations. Outcomes from this Consortium will substantially increase the depth and breadth of investigations on unusually successful cognitive aging. The factors to be identified will be directly relevant to sustained cognitive health in late life and to the concepts of resilience, resistance and cognitive reserve.

项目总结（临床/成像）： 老年人中普遍存在记忆投诉，衰老是阿尔茨海默病的主要危险因素 (AD)，导致人们认为记忆能力的逐渐丧失，最终导致痴呆症， 是变老的普遍后果。该联盟将探索另一种老化轨迹， 研究了80多岁的人，我们称之为“超级阿格”，他们的情景记忆表现， 似乎已经逃脱了年龄相关的下降，并保持在至少50-60岁的正常范围内， 岁，和。超级老年人的研究是在西北大学开始的，并将通过 这个财团。超级老龄化联盟的临床/成像核心将建立标准化的纳入 标准和统一评估，以协调超级老年人及其 对照目标1将协调至少500名受试者的入组和统一数据收集（300 SuperAgers，200个对照）纳入一项前瞻性纵向研究， 包括健康，生活方式和神经认知评估，以及MR成像，血液样本， 大脑捐赠将特别强调加强从研究中心招募不同参与者 在招募和对老年人的复杂描述方面具有优势。目标2将支持以下研究： 在更大和更多样化的队列中证实和扩展先前的发现，并确定新的因素 与异常成功的衰老有关目标3将通过支持开展新的调查方向 与该联合体有关的两个项目和合作调查。由此产生的结果 联盟将大大增加对异常成功的认知调查的深度和广度。 衰老有待确定的因素将直接关系到晚年的持续认知健康， 恢复力、抵抗力和认知储备的概念。