Clinical Core

临床核心

• 批准号: 10264369
• 负责人: SANDRA WEINTRAUB
• 金额: $ 47.42万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264369
• 关键词: Address; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Area; Autopsy; Basic Science; Biodiversity; Brain; Clinic; Clinical; Clinical Research; Cognitive; Cognitive Science; Cognitive aging; Collaborations; Community Outreach; Consensus; Consent; Consultations; Coronavirus; Data Set; Databases; Dementia; Diagnosis; Discipline; Disease; Education and Outreach; Enrollment; Environment; Event; Funding; Goals; Grant; Heterogeneity; Impaired cognition; Individual; Infrastructure; Intervention; Joints; Laboratories; Leadership; Longitudinal cohort; Measures; Medical Research; Mission; Modality; Nerve Degeneration; Neurology; Neuropsychology; Participant; Patient Recruitments; Patients; Prevention trial; Primary Progressive Aphasia; Psychiatry; Quality Control; Quality of life; Research; Research Personnel; Research Priority; Research Project Grants; Resistance; Resources; Role; Social Work; Social Workers; Source; Structure; Therapeutic; Time; Tissue Donations; Training; Translating; Work; Writing; aging brain; cohesion; cohort; data access; data exchange; data integration; data management; data resource; design; early onset; education research; faculty research; human subject; imaging biomarker; innovation; meetings; multidisciplinary; neurobehavior; neuroimaging; neuropathology; novel; outreach; pandemic disease; participant retention; preservation; programs; recruit; resilience; statistics; symposium; synergism; volunteer

PROJECT SUMMARY - CLINICAL CORE The Clinical Core will establish and maintain a cohort of extensively characterized individuals who have volunteered to participate in research projects addressing brain aging and dementia. In the next 5-year cycle, the Clinical Core of the Northwestern ADRC will continue to serve NIA and NAPA priorities for research on Alzheimer’s Disease and Alzheimer’s Related Dementias (AD/ADRD). At the same time, the Clinical Core will leverage local research programs within our longstanding theme of heterogeneity of cognitive aging and dementia, as reflected in the studies of unusually successful brain aging (SuperAging) and non-amnestic dementias (e.g., primary progressive aphasia). The emphasis on Alzheimer's disease will shift to earlier onset and pre-symptomatic stages with a view toward prevention trials. The SuperAging projects will explore factors that promote resilience to aging-related involutional changes and resistance to the emergence of Alzheimer’s pathology. The primary progressive aphasia program will help to clarify the biological diversity of Alzheimer's disease and the principles of selective vulnerability in focal brain neurodegeneration. In the next five years, the Clinical Core will support the following goals: 1) Maintain a diverse cohort of 500 research participants characterized by the Uniform Data Set (UDS) enhanced with center-specific measures, followed annually, and committed to neuroimaging, tissue donation and participation in national collaborations through NACC, ADCS, ADGC, NCRAD, and ADNI and in local collaborations investigating cognitive aging and dementia. 2) Promote areas of clinical and basic research where the Northwestern ADRC enjoys a national leadership role, such as SuperAging, primary progressive aphasia (PPA) and other FTLD-spectrum dementias, and encourage new investigators from outside fields at Northwestern to collaborate on AD/ADRD research. 3) Promote the 'therapeutic encounter' theme of the ADRC through the support of innovative non- pharmacologic interventions and establishment of long-term relationships between ORE Core social workers and Clinical Core participants for recruitment and retention. 4) Sustain a training approach that capitalizes on the multidisciplinary 'centerness' of the Northwestern ADRC and that serves the mission of the Research Education Component through the cultivation of an environment where trainees from different disciplines (basic and cognitive science, neurology, neuropsychology, psychiatry, social work, and neuroimaging) train together in contiguous space.

项目总结-临床核心 临床核心将建立并维持一个具有广泛特征的个体队列， 自愿参加研究脑老化和痴呆症的项目。在下一个五年周期中， 西北部ADRC的临床核心将继续为国家信息评估和国家适应行动计划的优先研究提供服务， 阿尔茨海默病和阿尔茨海默病相关痴呆（AD/ADRD）。同时，临床核心将 在我们长期以来的认知老化异质性主题中利用当地研究项目， 痴呆症，反映在异常成功的大脑老化（SuperAging）和非遗忘的研究 痴呆（例如，原发性进行性失语症）。老年痴呆症的重点将转向早期发病 和症状前阶段，以预防试验为目的。超级老龄化项目将探讨 促进对衰老相关的退化变化的恢复力和对阿尔茨海默氏症的抵抗力 病理初级进行性失语症计划将有助于澄清阿尔茨海默氏症的生物多样性 疾病和局灶性脑神经变性的选择性脆弱性的原则。 在未来五年，临床核心将支持以下目标： 1)维持一个由500名研究参与者组成的多样化队列，其特征在于统一数据集（UDS） 通过中心特定的措施加强，每年随访，并致力于神经影像学，组织 通过NACC、ADCS、ADGC、NCRAD和ADNI捐赠和参与国家合作， 在当地合作研究认知老化和痴呆症。 2)促进西北ADRC享有全国领导地位的临床和基础研究领域 作用，如超级老化，原发性进行性失语症（PPA）和其他FTLD谱系痴呆，以及 鼓励来自西北大学外部领域的新研究人员合作进行AD/ADRD研究。 3)通过支持创新的非政府组织，促进ADRC的“治疗遭遇”主题， 药物干预和建立长期的关系， 员工和临床核心参与者的招聘和保留。 4)维持一种利用西北大学多学科“中心”的培训方法 ADRC和服务的研究教育部分的使命，通过培养一个 来自不同学科（基础和认知科学，神经病学， 神经心理学、精神病学、社会工作和神经影像学）在相邻的空间一起训练。