CORE--CLINICAL

核心--临床

• 批准号: 6397802
• 负责人: SANDRA WEINTRAUB
• 金额: $ 28.97万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6397802
• 关键词: Alzheimer's disease; aphasia; biomedical facility; brain cell; caregivers; clinical research; clinical trials; cognition disorders; dementia; education; epidemiology; human subject; interview; longitudinal human study; medical outreach /case finding; mental disorder diagnosis; neurochemistry; neuropsychological tests; neuropsychology; phenotype; postmortem; psychiatry; psychometrics; statistics /biometry

This proposal describes the establishment of an Alzheimer's Disease Clinical Core unit at Northwestern University Medical School for the purpose of enhancing institutional initiatives related to the diagnosis, pathophysiology, molecular biology and treatment of Alzheimer's disease. To accomplish our goals, we will recruit and examine patients and nondemented control subjects and follow them at 6 month intervals. Every six months the neurological and neuropsychological examinations will be repeated and patients' caregivers will be interviewed in the context of "therapeutic encounters." Information obtained from these evaluations will be entered into a database maintained on-site. The follow-up visits will provide continuity of care and will identify cognitive or behavioral changes that might require alternative management strategies. Commitments for brain autopsy will be solicited. Patients and control subjects will be contacted episodically by investigators of projects approved by the Northwestern ADCC Executive Committee and will sign separate informed consent forms for projects in which they agree to participate. A minority outreach program will actively target a population that is underserved with respect to up-to-date AD care and will recruit patients for participation in the Clinical Core.

这项建议描述了建立一种阿尔茨海默病 西北大学医学院临床核心单位 加强与诊断相关的机构倡议的目的， 阿尔茨海默病的病理生理学、分子生物学和治疗。 为了实现我们的目标，我们将招募和检查患者，并 非痴呆对照受试者，每隔6个月进行一次跟踪调查。每个 六个月的神经学和神经心理学检查 重复和患者的护理人员将在以下背景下接受采访 “治疗上的接触。”从这些评价中获得的信息 将输入到现场维护的数据库中。随访团 将提供持续的护理，并将识别认知或行为 可能需要替代管理策略的变化。承诺 脑部尸检将会被征集。患者和对照受试者将 被批准的项目的调查人员偶尔联系 西北ADCC执行委员会并将另行签署通知 他们同意参与的项目的同意书。少数人 外展计划将积极针对服务不足的人群 关于最新的AD护理，并将招募患者用于 参与临床核心研究。