Rio Grande Valley Alzheimer's Resource Center for Minority Aging Research: Partnerships for Progress

里奥格兰德河谷阿尔茨海默病少数族裔老龄化研究资源中心：合作促进进步

• 批准号: 10730145
• 负责人: Gladys E. Maestre
• 金额: $ 63.93万
• 依托单位: UNIVERSITY OF TEXAS RIO GRANDE VALLEY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730145
• 关键词: Abbreviations; Academy; Address; Age of Onset; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Behavior; Behavior Therapy; Behavioral; Behavioral Model; Behavioral Research; Behavioral Sciences; Cardiovascular Diseases; Cardiovascular system; Caring; Cognitive; Communities; Complex; Data Analyses; Data Collection; Databases; Development; Diabetes Mellitus; Diagnosis; Discipline; Discrimination; Disparate; Disparity; Early Onset Alzheimer Disease; Economic Burden; Education; Educational Status; Elderly; Ethnic Population; Exhibits; Exposure to; Faculty; Family; Fostering; Funding; Genetic; Goals; Growth; Health; Health Personnel; Health Promotion; Health Sciences; Healthcare; Healthcare Systems; High Prevalence; Hispanic; Hispanic Americans; Hispanic Populations; Hispanic-serving Institution; Incidence; Individual; Infrastructure; Institution; Intervention; Ions; Kansas; Knowledge; Lead; Leadership; Letters; Life Style; Measures; Mediating; Mentors; Mentorship; Mexican Americans; Mexico; Minority; Minority Health Research; Modeling; Neighborhood Health Center; Neuropsychology; Neurosciences; Neurosciences Research; Not Hispanic or Latino; Obesity; Participant; Pathway interactions; Personal Satisfaction; Pilot Projects; Population; Positioning Attribute; Poverty; Prevention; Probability; Public Health; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Risk Factors; Science; Scientist; Social Change; Social Development; Social Sciences; Source; South Texas; Testing; Texas; Textiles; Time; Training; Training Programs; Training and Education; Underrepresented Minority; Underrepresented Populations; United States National Institutes of Health; Universities; Vision; career development; cohort; community engagement; community organizations; complex data; dementia risk; early life adversity; education research; educational atmosphere; evidence base; experience; health disparity; improve minority health; innovation; minority health; multidisciplinary; neuroimaging; programs; racial population; recruit; research study; skills; social; social interventions; sociodemographics; socioeconomics; therapy development; trait; working group

Summary – Overall Alzheimer’s disease (AD) and AD-related dementias (ADRD) disproportionately impact Hispanic Americans, who exhibit AD/ADRD rates 1.5 times higher and average onset 7 years earlier than do older Whites. Predicted growth of the US Hispanic population, faster in Texas portends exacerbation of the elevated health and economic burdens of AD/ADRD in Hispanics. A shortage of researchers focused on AD/ADRD in Hispanic Americans, particularly from underrepresented racial/ethnic groups, restricts progress in this area, and is a key factor contributing to the severe underrepresentation of Hispanic Americans in research studies in AD/ADRD. To overcome these barriers, responding to NIA's AD/ADRD RCMAR Program (RFA-AG-23-025), and leveraging the robust mentorship and research infrastructure our RCMAR developed during the first 5-yr funding cycle, we aim to continue the Rio Grande Valley AD/ADRD RCMAR: Partnership for Progress at the University of Texas Rio Grande Valley (UTRGV), one of the nation's largest Hispanic-serving institutions. We will combine evidence-based mentoring and support mechanisms to develop and promote a first-rate regional and national cadre of researchers from underrepresented groups, to analyze the complex mechanisms and interacting factors that contribute to disparate Hispanic AD/ADRD vulnerability. The Center will support development of social and behavioral interventions using the NIH Stage Model for Behavioral Intervention Development, considering pathways and developmental time points at which changes in social circumstances and behavior can exert the largest favorable impacts on the prevention and progression of AD/ADRD among Hispanic populations. The Center will also exploit its unique resources to develop infrastructure and data collections that will attract and support researchers from multiple disciplines to conduct research aimed at reducing impacts of AD/ADRD on Hispanics. UTRGV's socio-demographic profile reflects that of its local community, positioning it uniquely to advance studies of disparities in health & health care and contribute innovative solutions to improve minorities' health. To achieve the Center's goals, the aims are: 1) Identify, engage, mentor, and provide high-quality training and individualized career development support to outstanding faculty, especially from underrepresented groups; 2) Support innovative, high-impact multidisciplinary pilot projects; 3) Continue providing expertise and resources for culturally-sensitive measures & analysis of cognitive risk factors in older Hispanics, including behavioral, neuropsychological, neuroimaging, cardiovascular, and genetic traits; and 4) Create needed expertise & resources to develop social/behavioral interventions at different ecological levels, via sustained community engagement of older Hispanics and their care partners in South TX. We will achieve these aims by continuation of 3 Cores (Leadership & Admin., Analysis, Community Liaison/Recruitment) and the Research Education Component. The Center will also leverage & build upon experience of collaborators at the UTRGV Institute of Neuroscience and the South TX Diabetes & Obesity Institute, and NIA-South Texas AD Research Center.

总结 – 总体 阿尔茨海默病 (AD) 和 AD 相关痴呆 (ADRD) 对西班牙裔美国人的影响尤为严重， 他们的 AD/ADRD 发生率比老年白人高 1.5 倍，平均发病时间早 7 年。预测 美国西班牙裔人口的增长（德克萨斯州的增长速度更快）预示着健康状况的恶化和健康状况的恶化 西班牙裔 AD/ADRD 的经济负担。缺乏专注于西班牙裔 AD/ADRD 的研究人员 美国人，特别是来自代表性不足的种族/族裔群体，限制了这一领域的进展，并且是一个关键 导致西班牙裔美国人在 AD/ADRD 研究中代表性严重不足的因素。 为了克服这些障碍，响应 NIA 的 AD/ADRD RCMAR 计划 (RFA-AG-23-025)，以及 利用我们的 RCMAR 在第一个 5 年期间开发的强大的指导和研究基础设施 资金周期，我们的目标是继续里奥格兰德河谷 AD/ADRD RCMAR：合作伙伴关系，促进进步 德克萨斯大学里奥格兰德河谷分校 (UTRGV)，美国最大的拉美裔服务机构之一。我们 将结合以证据为基础的指导和支持机制，以开发和促进一流的区域 和来自代表性不足群体的国家研究人员骨干，以分析复杂的机制和 导致西班牙裔 AD/ADRD 脆弱性不同的相互作用因素。中心将支持 使用 NIH 行为干预阶段模型开发社会和行为干预措施 发展，考虑社会环境变化的途径和发展时间点 行为可以对AD/ADRD的预防和进展产生最大的有利影响 西班牙裔人口。该中心还将利用其独特的资源来开发基础设施和数据 馆藏将吸引和支持来自多个学科的研究人员进行旨在 减少 AD/ADRD 对西班牙裔的影响。 UTRGV 的社会人口概况反映了当地的情况 社区，其独特的定位是推进健康和医疗保健差异的研究，并做出贡献 改善少数族裔健康的创新解决方案。为了实现中心的目标，目标是： 1) 确定、 参与、指导并提供高质量的培训和个性化的职业发展支持 杰出的教师队伍，尤其是来自代表性不足的群体； 2) 支持创新、高影响力 多学科试点项目； 3) 继续为文化敏感措施提供专业知识和资源 老年西班牙裔认知风险因素分析，包括行为、神经心理学、神经影像学、 心血管和遗传特征； 4) 创建所需的专业知识和资源来发展社交/行为 通过老年西班牙裔及其他们的持续社区参与，在不同的生态层面进行干预 德克萨斯州南部的护理合作伙伴。我们将通过延续 3 个核心（领导力和管理、 分析、社区联络/招聘）和研究教育部分。该中心还将 利用和借鉴 UTRGV 神经科学研究所和德克萨斯州南部合作者的经验 糖尿病与肥胖研究所以及 NIA-南德克萨斯 AD 研究中心。

项目成果

Real-Time Mobile Teleophthalmology for the Detection of Eye Disease in Minorities and Low Socioeconomics At-Risk Populations.

• DOI: 10.1097/apo.0000000000000416
• 发表时间: 2021-09-01
• 期刊: Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
• 作者: Al-Aswad LA;Elgin CY;Patel V;Popplewell D;Gopal K;Gong D;Thomas Z;Joiner D;Chu CK;Walters S;Ramachandran M;Kapoor R;Rodriguez M;Alcantara-Castillo J;Maestre GE;Lee JH;Moazami G
• 通讯作者: Moazami G

Isolated Diastolic Hypertension in the IDACO Study: An Age-Stratified Analysis Using 24-Hour Ambulatory Blood Pressure Measurements.

• DOI: 10.1161/hypertensionaha.121.17766
• 发表时间: 2021-11
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: McEvoy JW;Yang WY;Thijs L;Zhang ZY;Melgarejo JD;Boggia J;Hansen TW;Asayama K;Ohkubo T;Dolan E;Stolarz-Skrzypek K;Malyutina S;Casiglia E;Lind L;Filipovský J;Maestre GE;Li Y;Wang JG;Imai Y;Kawecka-Jaszcz K;Sandoya E;Narkiewicz K;O'Brien E;Vanassche T;Staessen JA;International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes (IDACO) Investigators
• 通讯作者: International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes (IDACO) Investigators

Effect of 24-h blood pressure dysregulations and reduced ocular perfusion pressure in open-angle glaucoma progression.

• DOI: 10.1097/hjh.0000000000003537
• 发表时间: 2023-11-01
• 期刊: JOURNAL OF HYPERTENSION
• 影响因子: 4.9
• 作者: Melgarejo, Jesus D.;Eijgen, Jan V.;Wei, Dongmei;Maestre, Gladys E.;Al-Aswad, Lama A.;Liao, Chia-Te;Mena, Luis J.;Vanassche, Thomas;Janssens, Stefan;Verhamme, Peter;Zhang, Zhen-Yu;Keer, Karel V.;Stalmans, Ingeborg
• 通讯作者: Stalmans, Ingeborg

Evolutionary Couplings and Molecular Dynamic Simulations Highlight Details of GPCRs Heterodimers' Interfaces.

• DOI: 10.3390/molecules28041838
• 发表时间: 2023-02-15
• 期刊: MOLECULES
• 影响因子: 4.6
• 作者: Nchourupouo, Karim Widad Temgbet;Nde, Jules;Ngouongo, Yannick Joel Wadop;Zekeng, Serge Sylvain;Fongang, Bernard
• 通讯作者: Fongang, Bernard

Total Plasma Homocysteine and Depressive Symptoms in Older Hispanics.

• DOI: 10.3233/jad-201062
• 发表时间: 2021
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Castro F;Melgarejo J;Chavez CA;de Erausquin GA;Terwilliger JD;Lee JH;Maestre GE
• 通讯作者: Maestre GE