South Texas Alzheimer's Disease Center

南德克萨斯阿尔茨海默病中心

• 批准号: 10662308
• 负责人: Gladys E. Maestre
• 金额: $ 294.53万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10662308
• 关键词: Address; Advisory Committees; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Attitude; Autopsy; Behavioral; Behavioral Research; Big Data; Biological Markers; Biology; Blood; Blood Vessels; Brain; Capsicum; Caregiver support; Caregivers; Caring; Clinic; Clinical; Clinical Informatics; Clinical Research; Clinical Trials; Clinical assessments; Cognitive; Collaborations; Collection; Communities; Community Health Education; Comprehensive Health Care; Consent; Data; Data Collection; Data Set; Dementia; Development; Diabetes Mellitus; Dimensions; Discipline; Disparity; Doctor of Philosophy; Drug Targeting; Education; Elderly; Enrollment; Ensure; Epidemiology; Ethnic Origin; Exhibits; Face; Faculty; Family; Feces; Fibroblasts; Focus Groups; Gait; Genetic; Genomics; Geographic Locations; Goals; Grant; Health; Health Professional; Health Sciences; Heart; Heterogeneity; Hispanic; Hispanic Americans; Hispanic Populations; Image; Infrastructure; Institution; Intervention; Interview; Knowledge; Latino Population; Lead; Linguistics; Machine Learning; Magnetic Resonance Imaging; Medical Records; Mentors; Methods; Mexican Americans; Minority; Molecular; Motor; Music; Names; Nerve Degeneration; Neurology; Neurosciences; Pathologic; Pathology; Patient Care; Patients; Peripheral Blood Mononuclear Cell; Persons; Phenotype; Plasma; Population; Positron-Emission Tomography; Prevention; Printing; Privatization; Process; Proteomics; Public Health; Race; Radio; Research; Research Personnel; Research Priority; Resources; Retina; Saliva; Sampling; Science; Sensory; Series; Serum; Services; Site; Skin; South Texas; Spinal Cord; Statistical Methods; Subgroup; Testing; Texas; Time; Tissues; Training; Twitter; Underrepresented Minority; Universities; Urine; Vocational Guidance; Woman; biological heterogeneity; clinical center; clinical diagnosis; cohort; community engagement; community organizations; cost; data management; data sharing; dementia risk; design; digital; drug development; early onset; education research; effective intervention; ethnic minority; experience; frailty; health care availability; health care disparity; improved; improved outcome; induced pluripotent stem cell; innovation; lifestyle factors; lipidomics; metabolomics; molecular phenotype; multidisciplinary; multiple omics; neuropathology; novel; outreach; patient engagement; personalized medicine; population health; pragmatic implementation; pre-clinical; precision medicine; preference; recruit; resilience; risk prediction; social; socioeconomics; web site

Alzheimer´s disease (AD) and related disorders (ADRD) disproportionally impacts Hispanics/Latinos, who exhibit higher rates, earlier onset and face unique challenges due to cultural, linguistic, socioeconomic or healthcare access problems. Moreover, there is a shortage of researchers focused on ADRD in Mexican- American (MA) Hispanics, the fastest growing minority in the US. Addressing the heterogeneity of ADRD presentation and biology, using precision medicine approaches to improve risk prediction, target prevention and treatment is likely to improve outcomes for MA and others. The proposed South Texas Alzheimer disease Center (STAC) will exploit its unique geographic location in South Texas, a region of ~5 million, underserved MA to develop infrastructure and data/biosample collections that will support researchers from multiple disciplines to conduct research to diminish the burden of AD in Hispanics. We have 6 specific aims: (1) Collecting and sharing longitudinal data from patients, controls and caregivers (2) Exploring the biological heterogeneity of preclinical and clinical dementia, through deep phenotyping with clinical, imaging, genetic, omic, CSF, blood and sensory-motor biomarkers and autopsy of all these enrollees (3) Focusing especially for Aims #1 and #2 on Hispanic/Latino individuals (4) Identifying novel predictors/ biomarkers of dementia risk and resilience, including for poorly understood clinic-pathologic subgroups such as Suspected Non-Alzheimer (amyloid negative, neurodegeneration positive) Pathology [SNAP] in Hispanics with/without diabetes, (5) To recruit, train, mentor and support a diverse research workforce, largely women and minorities, to become leaders in multidisciplinary, team-based, ADRD research, (6) Bidirectional community education and engagement, research into knowledge, attitudes and practices/preferences. The STAC will develop and share culturally sensitive deep phenotyping methods beyond the Uniform Dataset (including novel cognitive, behavioral, vascular, lifestyle factors, biomarkers), genetics and multi- dimensional omics within community- based and patient and caregiver (dyadic) cohorts. Using state of the art clinical informatics and statistical methods, these rich data should permit an exploration of the molecular heterogeneity of ADRD and uncover novel biology and drug targets, treatment approaches. Finally we will collaborate, share data/samples and expertise with other institutions in Texas and around the world, especially other ADRC Centers, the NACC, NCRAD, NIAGADS. We will achieve these aims through creation of six required Cores and one component: Administrative, Clinical, Data Management and Statistical, Neuropathology, Outreach, Recruitment and Engagement, Biomarker Cores and the Research Education Component. In addition, we propose three Optional Cores: Population Neuroscience, Imaging and Genetics and Multiomics Cores. The STAC will serve as a national resource for disruptive, transformative and innovative research and the design, development, testing and implementation of practical strategies to diminish the burden of AD in Hispanics.

阿尔茨海默病（AD）和相关疾病（ADRD）对西班牙裔/拉丁裔人造成了严重影响， 发病率较高，发病较早，并因文化、语言、社会经济或 医疗服务的问题。此外，墨西哥缺乏专注于ADRD的研究人员- 美国（MA）西班牙裔，在美国增长最快的少数民族。解决ADRD的异质性 介绍和生物学，使用精准医学方法来改善风险预测，目标预防 治疗可能会改善MA和其他疾病的结果。南德克萨斯阿尔茨海默病 中心（STAC）将利用其在南德克萨斯州的独特地理位置，该地区约有500万人口， MA开发基础设施和数据/生物样本收集，以支持来自多个国家的研究人员 学科进行研究，以减少西班牙裔AD的负担。我们有6个具体目标：（1） 收集和共享患者、对照组和护理人员的纵向数据（2）探索生物学 临床前和临床痴呆的异质性，通过临床，成像，遗传， 所有这些入组者的组学、CSF、血液和感觉运动生物标志物和尸检（3）特别关注 西班牙裔/拉丁裔个体的目标#1和#2（4）确定痴呆风险的新预测因子/生物标志物 和恢复力，包括对临床病理亚组知之甚少，如疑似非阿尔茨海默病 （淀粉样蛋白阴性，神经变性阳性）有/无糖尿病的西班牙裔的病理学[SNAP]，（5）To 招募，培训，指导和支持多元化的研究队伍，主要是妇女和少数民族，成为 领导者在多学科，团队为基础，ADRD研究，（6）双向社区教育和 参与，研究知识，态度和做法/偏好。STAC将开发和共享 超越统一数据集的文化敏感的深度表型分析方法（包括新的认知， 行为、血管、生活方式因素、生物标志物）、遗传学和社区内的多维组学- 基于患者和护理人员（二元）队列。使用最先进的临床信息学和统计学 方法，这些丰富的数据应该允许探索ADRD的分子异质性，并揭示 新的生物学和药物靶点，治疗方法。最后，我们将合作，分享数据/样本， 专业知识与其他机构在得克萨斯州和世界各地，特别是其他ADRC中心，NACC， NCRAD，尼亚加拉。我们将通过创建六个必要的核心和一个组件来实现这些目标： 行政、临床、数据管理和统计、神经病理学、外展、招募和 参与，生物标志物核心和研究教育组成部分。此外，我们建议三个 可选核心：人口神经科学，成像和遗传学和多组学核心。STAC将服务于 作为一个国家资源的破坏性，变革性和创新性的研究和设计，开发， 测试和实施切实可行的战略，以减少西班牙裔AD的负担。

项目成果

Assessing urinary phenol and paraben mixtures in pregnant women with and without gestational diabetes mellitus: A case-control study.

• DOI: 10.1016/j.envres.2022.113897
• 发表时间: 2022-11
• 期刊: ENVIRONMENTAL RESEARCH
• 影响因子: 8.3
• 作者: Chen, Wei-Jen;Robledo, Candace;Davis, Erin M.;Goodman, Jean R.;Xu, Chao;Hwang, Jooyeon;Janitz, Amanda E.;Garwe, Tabitha;Calafat, Antonia M.;Peck, Jennifer D.
• 通讯作者: Peck, Jennifer D.

Demographic and Clinical Characteristics Associated With Serum GFAP Levels in an Ethnically Diverse Cohort.

不同种族人群中与血清 GFAP 水平相关的人口统计和临床特征。

• DOI: 10.1212/wnl.0000000000207706
• 发表时间: 2023
• 期刊: Neurology
• 影响因子: 9.9
• 作者: Gonzales,MitziM;Vela,Gabriel;Philip,Vinu;Trevino,Hector;LaRoche,Ashley;Wang,Chen-Pin;Parent,DanielleM;Kautz,Tiffany;Satizabal,ClaudiaL;Tanner,Jeremy;O'Bryant,Sid;Maestre,Gladys;Tracy,RussellP;Seshadri,Sudha
• 通讯作者: Seshadri,Sudha

Authors' response.

作者的回应。

• DOI: 10.1016/j.anai.2018.10.015
• 发表时间: 2018
• 期刊: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
• 作者: Spergel,JonathanM;Dellon,EvanS;Liacouras,ChrisA;Hirano,Ikuo;Molina-Infante,Javier;Bredenoord,AlbertJ;Furuta,GlennT
• 通讯作者: Furuta,GlennT

Microglia: Friend and foe in tauopathy.

• DOI: 10.1016/j.pneurobio.2022.102306
• 发表时间: 2022-09
• 期刊: PROGRESS IN NEUROBIOLOGY
• 影响因子: 6.7
• 作者: Odfalk, Kristian F.;Bieniek, Kevin F.;Hopp, Sarah C.
• 通讯作者: Hopp, Sarah C.

Covariance shrinkage can assess and improve functional connectomes.

• DOI: 10.1016/j.neuroimage.2022.119229
• 发表时间: 2022-08-01
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Honnorat, Nicolas;Habes, Mohamad
• 通讯作者: Habes, Mohamad