Rio Grande Valley Alzheimer's Resource Center for Minority Aging Research: Partnerships for Progress

总体摘要 阿尔茨海默病S病(AD)是一种与衰老相关的疾病，对拉美裔/拉美裔美国人影响不成比例， 他们的AD发病率是老年白人的1.5倍，平均发病时间提前7年。预测增长 美国拉美裔人口的增加，尤其是德克萨斯州的增长速度更快，预示着这种不平衡进一步加剧-- 在西班牙裔美国人中，AD升高带来的健康和经济负担。目前还缺乏专注于 拉美裔人，特别是代表人数不足的种族/族裔群体的AD及相关障碍。至 克服这些障碍，拟议的少数族裔老龄化研究AD资源中心(AD-RCMAR) 德克萨斯大学里奥格兰德山谷(UTRGV)是美国最大的拉美裔服务机构之一，将 结合循证指导和支持机制，发展和促进一流的区域和 国家研究人员队伍，特别是来自代表性不足的群体，以分析复杂的机械- 西班牙裔美国人对AD的不同脆弱性的原因和相互作用的因素。该中心将提供以下支持- 确定社会环境和环境变化的路径和发展时间点 行为可以对拉美裔AD的预防和进展产生最大的有利影响。这个 UTRGV AD-RCMAR将利用其独特的资源开发基础设施和数据收集，将在- 追踪和支持来自多个学科和不同科学生涯阶段的研究人员，并允许他们 开展旨在减少AD对拉美裔美国人影响的研究。中国的社会人口概况 UTRGV反映了其当地社区的特点，该中心的定位独特，以推进对 卫生和医疗保健，并为改善少数群体的健康贡献创新的解决方案。我们将实现 中心的目标通过4个具体目标实现：1)确定、参与、指导和提供高质量的培训和个人- 向优秀教师提供职业发展支持，特别是来自代表性不足群体的支持；2)支持 港口创新、高影响力的多学科试点项目；3)为文化- 对老年拉美裔美国人认知风险因素的敏感测量和分析，包括行为、神经和 心理、神经成像、心血管和遗传特征；以及4)创造必要的专业知识 和资源，以建立老年拉美裔及其家庭的纵向研究队列。我们将实现 通过创建4个核心(行政、研究、教育、分析和社区)来实现这些目标 联络/招聘)，以支持AD研究。该中心将建立在调查人员在 UTRGV神经科学研究所及其在南得克萨斯糖尿病和肥胖研究所的合作者，以及 华盛顿大学广告研究中心。

Summary OVERALL Alzheimer´s disease (AD) is an aging-associated disorder that disproportionately impacts Hispanics/Latinos, who exhibit AD rates 1.5 times higher and average onset 7 years earlier than do older whites. Predicted growth of the US Hispanic population, particularly faster in Texas, portends further exacerbation of the disproportion- ate health and economic burdens of elevated AD in Hispanics. There is a shortage of researchers focused on AD and related disorders (ADRD) in Hispanics, particularly from underrepresented racial/ethnic groups. To overcome these barriers, the proposed AD Resource Center for Minority Aging Research (AD-RCMAR) at the University of Texas Rio Grande Valley (UTRGV), one of the nation's largest Hispanic-serving institutions, will combine evidence-based mentoring and support mechanisms to develop and promote a first-rate regional and national cadre of researchers, particularly from under-represented groups, to analyze the complex mecha- nisms and interacting factors that contribute to Hispanics' disparate vulnerabilities to AD. The Center will sup- port identification of pathways and developmental time points at which changes in social circumstances and behavior can exert the largest favorable impacts on prevention and progression of AD among Hispanics. The UTRGV AD-RCMAR will exploit its unique resources to develop infrastructure and data collections that will at- tract and support researchers from multiple disciplines and at different scientific career stages, and allow them to conduct research aimed at reducing the impacts of AD on Hispanics. The socio-demographic profile of UTRGV reflects that of its local community, positioning the Center uniquely to advance studies of disparities in health and health care and contribute innovative solutions to improve minorities' health. We will achieve the Center's goals via 4 specific aims: 1) to identify, engage, mentor, and provide high-quality training and individu- alized career development support to outstanding faculty, especially from underrepresented groups; 2) to sup- port innovative, high-impact multidisciplinary pilot projects; 3) to provide expertise and resources for culturally- sensitive measurement and analysis of cognitive risk factors in older Hispanics, including behavioral, neuro- psychological, neuroimaging, and cardiovascular and genetic traits; and 4) to create the necessary expertise and resources to establish longitudinal research cohorts of older Hispanics and their families. We will achieve these aims through the creation of 4 Cores (Administrative; Research Education; Analysis; and Community Liaison/Recruitment) to support AD research. The Center will build upon the experience of investigators at the UTRGV Institute of Neuroscience and collaborators at the South Texas Diabetes & Obesity Institute, and Washington University's AD Research Center.