The Mobile Toolbox for Monitoring Cognitive and Behavioral Function (MTB2)

总体汇总 区分正常和病理性认知变化并确定相关的风险因素至关重要 在预防、早期诊断和早期干预轻度认知障碍（MCI）、阿尔茨海默病 和阿尔茨海默病相关痴呆（AD/ADRD）。移动的监测系统的目标 认知和行为功能更新（MTB 2）是扩展移动的记忆库的一种简单而敏感的 建立一个全面的研究平台，可以远程评估神经和行为 在大规模的研究中，在整个生命周期中发挥作用。扩大后的山地车将作为一种“共同 研究人员可以在不同的研究设计和人群中使用“货币”。我们将解决MTB 2 通过MTB的扩展、广泛传播和支持实现以下目标： 1.添加经过验证和规范的基于iOS和Android智能手机的措施库，以评估 非认知领域在人的一生中会发生变化MTB评估库将添加更改- 已知影响认知能力的生理、心理、社会和行为结构的敏感指标 轨迹和/或前驱MCI和AD/ADRD。新措施将根据金本位措施进行验证 在20-85岁的健康成年人中，在健康和认知障碍成年人样本中进行临床验证，然后 在全国代表性的年龄分层样本中进行规范。 2.扩展和维护软件平台，以支持临床研究人员和软件开发人员 将MTB图书馆动态、可定制地整合到研究中。MTB使 研究人员选择现有的措施和贡献新的，管理研究方案，并接收，存储， 聚合、分析和（适当时）共享数据。我们将利用现有的平台，开发新的 收集通过移动的设备上的无源或可连接生物传感器捕获的健康和行为数据的功能。 MTB 2测量的软件代码，沿着协议，规范数据和分析管道将被制作 向研究界开放。 3.发展和支持不断增长的用户群，确保成本回收努力，并持续 平台的发展和完善。MTB将适应新的研究发起的措施 并实现去识别数据共享。一个完整的客户支持设施将被创建，以鼓励潜在的 MTB用户探索和试驾MTB。他们将可以访问在线帮助系统， 客户支持，将直接向适当的科学家和软件解决问题或分类请求 开发人员，利用我们开发目前支持NIH的成本回收模型的经验 确保山地车的持续生存能力。

Overall Summary Differentiating normal from pathological cognitive change and identifying associated risk factors is essential in prevention, early diagnosis, and early intervention for mild cognitive impairment (MCI), Alzheimer's Disease, and Alzheimer's Disease-Related Dementia (AD/ADRD). The goal of The Mobile Toolbox for Monitoring Cognitive and Behavioral Function renewal (MTB2) is to expand the Mobile Toolbox library of brief and sensitive measures to create a comprehensive research platform that can remotely assess neurological and behavioral functions across the lifespan in large-scale studies. The expanded MTB will serve as a form of “common currency” that researchers can use across diverse study designs and populations. We will address the MTB2 goals through the expansion, widespread dissemination, and support of the MTB as follows: 1. Add a validated and normed library of iOS and Android smartphone-based measures to assess non-cognitive domains known to change across the lifespan. The MTB assessment library will add change- sensitive measures of physical, psychological, social, and behavioral constructs known to influence cognitive trajectories and/or prelude MCI and AD/ADRD. New measures will be validated against gold standard measures in healthy adults ages 20-85, clinically validated in a sample of healthy and cognitively impaired adults, and then normed in a nationally representative age-stratified sample. 2. Extend and maintain a software platform to support clinical researchers and software developers in the dynamic, customizable integration of the MTB library into research studies. The MTB enables researchers to select existing measures and contribute new ones, manage study protocols, and receive, store, aggregate, analyze, and (as appropriate) share data. We will curate the existing platform and develop new functionality to gather health and behavior data captured via passive or attachable biosensors on mobile devices. Software code for MTB2 measures, along with protocols, normative data, and analytical pipelines will be made openly available to the research community. 3. Develop and support a growing user base, ensure cost-recovery efforts, and sustain continued development and refinement of the platform. The MTB will accommodate new research-initiated measures and enable de-identified data sharing. A complete customer support facility will be created to encourage potential MTB users to explore and test-drive the MTB. They will have access to an online help system and same-day customer support, which will directly address issues or triage requests to appropriate scientists and software developers, leveraging our experience developing the cost recovery models that currently support the NIH Toolbox and PROMIS measures, ensuring the continuing viability of the MTB.