Clinical Research Core

WF OAIC临床研究核心(CRC)提供必要的基础设施和研究人员资源 对成功开展以老年人身体功能和残疾为重点的临床研究至关重要。 CRC与其他OAIC资源核心(生物成像、综合生物学和 生物统计和研究信息系统)。与他们密切合作，研究中心将支持研究 教育部分(REC)-支持的学者、OAIC试点研究、外部资助的研究和OAIC 与WF OAIC研究主题相关的研究开发项目：“整合影响 身体机能是残疾治疗和预防的新方法。“ 在芭芭拉·尼克拉斯博士、杰夫·威廉姆森博士和克里斯汀·比弗斯博士的领导下，儿童基金会将协助 领导和行政核心(LAC)、试点和探索性研究核心(PESC)和REC 确定有希望的新研究人员和计划，以帮助解决物理机制 残疾和努力减少或消除与年龄有关的功能障碍。启联将提供“交钥匙”资源 对成功的临床研究至关重要，包括：1)与实验研究设计和 行为，包括选择适当的成果衡量标准；2)高效率和有效的参与者 征聘；3)包含重要理解的关键措施的共同评估小组 改变身体机能；以及4)协助职业生涯早期调查人员与内部审查委员会和其他 监管备案(与PESC和REC合作)。在本周期内，提供这些密钥 资源对我们及时完成临床研究、公布结果、竞争 新的独立资助的赠款，以及开发新的调查人员。 在下一个周期的第一年，儿童权利中心将支持19项研究：2个区域经济合作委员会奖学金项目、2个试点项目和 探索性研究、1个开发项目和14个外部资助项目。开发项目将 将由儿童研究中心领导，其目标将是通过加强 社会经济地位较低的老年人参与研究。得到资助的研究涵盖了广泛的 一系列以OAIC为主题的研究，包括测试针对衰老相关生物途径的干预措施 人类，优化身体成分以改善身体功能，纳入与中枢神经系统相关的措施和 将概念转化为身体功能和残疾途径，并扩大研究工作和传播 整个学术学习医疗系统的结果。

The WF OAIC Clinical Research Core (CRC) provides essential infrastructure and investigator resources critical to the successful conduct of clinical research focusing on physical function and disability in older adults. The CRC is well-integrated with the other OAIC Resource Cores (Bioimaging, Integrative Biology, and Biostatistics and Research Information Systems). Working closely with them, the CRC will support Research Education Component (REC)-supported Scholars, OAIC pilot studies, externally-funded studies, and OAIC Research Development Projects related to the WF OAIC research theme: “Integrating pathways affecting physical function for new approaches to disability treatment and prevention.” Under the leadership of Drs. Barbara Nicklas, Jeff Williamson, & Kristen Beavers, the CRC will assist the Leadership and Administrative Core (LAC), the Pilot and Exploratory Studies Core (PESC), and the REC in identifying promising new investigators and programs positioned to help address the mechanisms of physical disability and work to reduce or eliminate age-related dysfunction. The CRC will provide ‘turn-key’ resources critical for successful clinical research studies, including: 1) expertise related to experimental study design and conduct, including selection of appropriate outcome measures; 2) highly efficient and effective participant recruitment; 3) a common assessment battery incorporating key measures important to understanding changing physical function; and 4) assisting early-career investigators with Internal Review Board and other regulatory filings (in collaboration with the PESC and REC). In the present cycle, provision of these key resources has been integral to our timely completion of clinical studies, publication of results, competition for new independently-funded grants, and development of new investigators. In the first year of the next cycle, the CRC will support 19 studies: 2 REC Scholar Projects, 2 Pilot and Exploratory Studies, 1 Development Project, and 14 Externally-funded Projects. The Development Project will be led by the CRC and its goal will be to increase the generalizability of WF OAIC research by enhancing the research participation of older adults with lower socio-economic status. The supported studies cover a broad range of OAIC-themed research, including testing interventions targeting aging-related biologic pathways in humans, optimizing body composition to improve physical function, incorporating CNS-relevant measures and concepts into the physical function and disability pathway, and expanding research conduct and disseminating results across the academic learning healthcare system.