Clinical Research Core

WF OAIC临床研究核心（CRC）提供必要的基础设施和研究者资源 这对于成功开展以老年人身体功能和残疾为重点的临床研究至关重要。 CRC与其他OAIC资源核心（生物成像、综合生物学和 生物统计学和研究信息系统）。与他们密切合作，CRC将支持研究 教育部分（REC）支持的学者，OAIC试点研究，外部资助的研究，和OAIC 与WF OAIC研究主题相关的研究发展项目：“整合影响 身体功能的新方法来治疗和预防残疾。” 在Barbara Nicklas、Jeff威廉姆森和Kristen Beavers博士的领导下，CRC将协助 领导力和行政核心（LAC），试点和探索性研究核心（PESC），以及REC 确定有前途的新的研究人员和计划，以帮助解决物理机制， 残疾和工作，以减少或消除与年龄有关的功能障碍。CRC将提供“交钥匙”资源 成功的临床研究的关键，包括：1）与实验研究设计相关的专业知识， 行为，包括选择适当的结果措施; 2）高效和有效的参与者 3）一个共同的评估组合，其中包括对了解 改变身体功能;以及4）协助早期职业调查员与内部审查委员会和其他 监管备案（与PESC和REC合作）。在本周期内，提供这些关键 资源一直是我们及时完成临床研究，发表结果，竞争， 新的独立资助赠款和新的研究人员的发展。 在下一个周期的第一年，CRC将支持19项研究：2项REC学者项目，2项试点项目， 探索性研究、1个发展项目和14个外部供资项目。发展项目将 由CRC领导，其目标是通过增强WF OAIC研究的普遍性 社会经济地位较低的老年人参与研究。支持的研究涵盖广泛的 一系列以OAIC为主题的研究，包括测试针对衰老相关生物途径的干预措施， 人类，优化身体成分以改善身体功能，结合CNS相关措施， 概念纳入身体功能和残疾途径，并扩大研究开展和传播 整个学术学习医疗保健系统的结果。

The WF OAIC Clinical Research Core (CRC) provides essential infrastructure and investigator resources critical to the successful conduct of clinical research focusing on physical function and disability in older adults. The CRC is well-integrated with the other OAIC Resource Cores (Bioimaging, Integrative Biology, and Biostatistics and Research Information Systems). Working closely with them, the CRC will support Research Education Component (REC)-supported Scholars, OAIC pilot studies, externally-funded studies, and OAIC Research Development Projects related to the WF OAIC research theme: “Integrating pathways affecting physical function for new approaches to disability treatment and prevention.” Under the leadership of Drs. Barbara Nicklas, Jeff Williamson, & Kristen Beavers, the CRC will assist the Leadership and Administrative Core (LAC), the Pilot and Exploratory Studies Core (PESC), and the REC in identifying promising new investigators and programs positioned to help address the mechanisms of physical disability and work to reduce or eliminate age-related dysfunction. The CRC will provide ‘turn-key’ resources critical for successful clinical research studies, including: 1) expertise related to experimental study design and conduct, including selection of appropriate outcome measures; 2) highly efficient and effective participant recruitment; 3) a common assessment battery incorporating key measures important to understanding changing physical function; and 4) assisting early-career investigators with Internal Review Board and other regulatory filings (in collaboration with the PESC and REC). In the present cycle, provision of these key resources has been integral to our timely completion of clinical studies, publication of results, competition for new independently-funded grants, and development of new investigators. In the first year of the next cycle, the CRC will support 19 studies: 2 REC Scholar Projects, 2 Pilot and Exploratory Studies, 1 Development Project, and 14 Externally-funded Projects. The Development Project will be led by the CRC and its goal will be to increase the generalizability of WF OAIC research by enhancing the research participation of older adults with lower socio-economic status. The supported studies cover a broad range of OAIC-themed research, including testing interventions targeting aging-related biologic pathways in humans, optimizing body composition to improve physical function, incorporating CNS-relevant measures and concepts into the physical function and disability pathway, and expanding research conduct and disseminating results across the academic learning healthcare system.