The Iowa Flood Study: Perinatal Effects of a Natural Disaster

爱荷华州洪水研究：自然灾害对围产期的影响

• 批准号: 7666000
• 负责人: MICHAEL William O'HARA
• 金额: $ 14.94万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-08 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7666000
• 关键词: 11-beta-Hydroxysteroid Dehydrogenases; Adrenal Glands; Adult; Affect; Animals; Anxiety; Autistic Disorder; Behavioral; Biological; Biological Assay; Biological Factors; Biological Markers; Biological Process; Birth; Blood; Blood flow; Blood specimen; Brain; Breast Feeding; Catecholamines; Characteristics; Child; Childhood; Cognitive; Collaborations; Complex; Complication; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone Receptors; Data; Data Collection; Data Set; Development; Disasters; Discipline of obstetrics; Distress; Elements; Emotional; Event; Exposure to; Female; Fetal Growth Retardation; Fetus; Figs - dietary; Floods; Funding; Future; Gases; Genes; Genetic Predisposition to Disease; Gestational Age; Glucocorticoids; Glucose; Glucose Transporter; Goals; Grant; Growth; Healed; Human; Hydrocortisone; Hypothalamic structure; Immune system; Infant; Infant Behavior; Infant Development; Infant Health; Inflammatory; Intervention; Iowa; Link; Low Birth Weight Infant; Maternal Exposure; Maternal Health; Mediating; Mental Health; Mental disorders; Midwestern United States; Modeling; Moods; Morphology; Mothers; Motor; Natural Disasters; Nature; Neurosecretory Systems; Newborn Infant; Nutrient; Outcome; Oxidative Stress; Pain; Perinatal; Pituitary Gland; Placenta; Placental Lactogen; Positioning Attribute; Post-Traumatic Stress Disorders; Postpartum Depression; Postpartum Period; Postpartum Women; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Process; Production; Prospective Studies; Protocols documentation; Psychosocial Factor; Public Health; Randomized; Reaction; Recording of previous events; Relative (related person); Research; Retrospective Studies; Risk; Salivary; Sampling; Schizophrenia; Social support; Socioeconomic Status; Stress; Students; Symptoms; System; Temperament; Testing; Time; TimeLine; Trauma; Umbilical Cord Blood; Umbilical cord structure; Weight; Woman; Work; biological adaptation to stress; biopsychosocial; coping; cytokine; demographics; depression; experience; fetal; fetal blood; healing; human HGH-V protein; hypothalamic-pituitary-adrenal axis; immune function; indexing; infant outcome; male; maternal stress; offspring; oxygen transport; pregnant; prenatal; prenatal stress; protective effect; psychologic; psychosocial; public health relevance; response; sex; social; stressor; unborn child

DESCRIPTION (provided by applicant): Animal studies show that prenatal maternal stress (PNMS) results in maternal glucocorticoids passing the placental barrier and disrupting fetal brain development, particularly the hypothalamic-pituitary-adrenal axis. This in turn influences pregnancy outcomes and offspring development. To date, however, there have been no prospective studies of pregnant women exposed to a sudden-onset natural disaster that have been able to elucidate the biopsychosocial mechanisms responsible for the wide variety of consequences of prenatal stress seen in human and animal offspring. As such, the goal of this project is to increase our understanding of the mechanisms responsible for the effects of maternal exposure to varying levels of hardship, and the pregnant women's subjective reactions to these hardships, imposed by a severe, independent stressor: the U.S. Midwest floods of June 2008. We will determine the extent to which the effects of various components of disaster on the mother, the pregnancy and infant may be moderated by biological, psychological, and social factors on a sample of approximately 420 women who had either given birth shortly before the flooding, or who were pregnant during the flooding, or who became pregnant within 3 months after the flooding. An important element of this study is that pre-flood data are available on the psychological functioning, coping, and social support in 135 pregnant and postpartum women. Here, we propose to augment this on-going study with a new protocol involving two timelines. One data collection timeline will be linked to the flooding, and will assess symptoms of post-traumatic stress disorder (PTSD) and coping, and collect diurnal salivary cortisol, at recruitment, 6- and 12-months post-flood. A second timeline is linked to the pregnancy and involves data collection at recruitment, at 30-32 weeks gestation, delivery, and 6-months postpartum; these will assess maternal mood, biomarkers from maternal blood, and infant behavior over time. We predict that higher levels of PNMS will be associated with poorer maternal health outcomes (PTSD, postpartum depression). We also predict that higher levels of PNMS and higher pregnancy cortisol levels will be associated with more obstetric and newborn complications, poorer infant health, poorer neuromotor maturity at birth, blunted reactive cortisol levels, as well as more difficult temperament. We believe that placental functioning will be a central mechanism for these effects: prenatal stress will be associated with altered placental functioning which will be associated with poorer perinatal and infant outcomes. This RAPID grant will enable us to collect (and to a limited extent analyze) the most comprehensive data set ever obtained for studying the effects of an independent stressor on PTSD, postpartum depression, pregnancy outcomes and infant development. By obtaining a multitude of maternal and infant biomarkers and by evaluating the functioning of the placenta, we will be in a position to test a comprehensive biopsychosocial model of prenatal maternal stress. The results of this collaboration should point us towards interventions that will effectively limit the damage to mother and fetus when disasters occur. PUBLIC HEALTH RELEVANCE: The proposed research has significant relevance to public health because it will allow a more clear delineation of the effects of a significant independent stressor (flooding) on the course and outcome of pregnancy. This work will have implications for our understanding of biopsychosocial nature of the effects of stress on maternal mental health and infant health.

描述（由申请人提供）：动物研究表明，产前母体应激（PNMS）导致母体糖皮质激素通过胎盘屏障并破坏胎儿脑发育，特别是下丘脑-垂体-肾上腺轴。这反过来又会影响怀孕结果和后代的发育。然而，到目前为止，还没有一项关于孕妇暴露于突发自然灾害的前瞻性研究能够阐明导致人类和动物后代产前应激的各种后果的生物心理社会机制。因此，本项目的目标是增加我们对产妇暴露于不同程度的困难的影响的机制的理解，以及孕妇对这些困难的主观反应，由一个严重的，独立的压力源：美国中西部洪水2008年6月。我们将确定在何种程度上的影响的各种组成部分的灾难对母亲，怀孕和婴儿可能是缓和的生物，心理和社会因素的样本约420名妇女谁要么分娩前不久的洪水，或谁怀孕期间，或谁怀孕后3个月内的洪水。这项研究的一个重要因素是，洪水前的数据可在135名孕妇和产后妇女的心理功能，应对和社会支持。在这里，我们建议用一个涉及两个时间线的新方案来加强这项正在进行的研究。一个数据收集时间轴将与洪水联系起来，并将评估创伤后应激障碍（PTSD）和应对的症状，并在招募时、洪水后6个月和12个月收集昼夜唾液皮质醇。第二个时间轴与妊娠相关，涉及招募时、妊娠30-32周、分娩和产后6个月的数据收集;这些将评估母体情绪、来自母体血液的生物标志物和婴儿随时间的行为。我们预测，较高水平的PNMS将与较差的孕产妇健康结果（PTSD，产后抑郁症）相关。我们还预测，较高水平的PNMS和较高的妊娠皮质醇水平将与更多的产科和新生儿并发症，婴儿健康状况较差，出生时神经运动成熟度较差，反应性皮质醇水平减弱以及更难相处的气质。我们认为，胎盘功能将是这些影响的中心机制：产前应激将与胎盘功能改变，这将与围产期和婴儿结局较差。这项快速拨款将使我们能够收集（并在有限程度上分析）有史以来最全面的数据集，用于研究独立压力源对PTSD，产后抑郁症，妊娠结局和婴儿发育的影响。通过获得大量的产妇和婴儿的生物标志物，并通过评估胎盘的功能，我们将能够测试一个全面的产前产妇压力的生物心理社会模型。这种合作的结果应该为我们指明干预措施，以便在灾害发生时有效地限制对母亲和胎儿的损害。 公共卫生关系：拟议的研究与公共卫生具有重要意义，因为它将允许更清楚地描述一个重要的独立压力源（洪水）对怀孕过程和结果的影响。这项工作将对我们理解压力对产妇心理健康和婴儿健康的影响的生物心理社会性质产生影响。